Research to understand the fundamental mechanisms and causes of biological processes is an integral part of the three-legged stool upon which Wellman’s research program has been established. Investigating processes at the cellular and sub-cellular levels expands our knowledge of the inter-connectivity within the entire human biological system. It is not necessarily the intent of basic research to lead to clinically applicable findings. It is usually difficult to predict results or where they may lead. But ultimately, few successful clinical applications are developed without first understanding the fundamental biological processes involved.