Yun Lab focuses on developing new optical technologies and applying them to solve biological questions and medical problems.  To realize this goal, we integrate our expertise in physics, photonics, and various engineering disciplines with biomedical needs and curiosities. Our research activities therefore include multidisciplinary collaboration particularly with biologists and clinicians.  Also we sometimes jointly pursue collaboration with industrial partners to enhance the practical impacts of research. Current research projects are as follows:

Technologies
Optical coherence tomography
In vivo confocal and multiphoton microscopy
Miniature mouse endomicroscopy
Brillouin biomechanical imaging
Microrheology
Adaptive light focusing in tissue
Novel bio-lasers
Novel optical devices for medical and military applications

Collaborative projects
  -  Cellular and molecular studies using small-animal       models of inflammatory bowel disease, colon cancer,       chronic organ rejection, etc.
  -  Diagnosis of cataract, presbyopia, and corneal       problems
  -  Delivery and toxicity of nanoparticles in vivo
  -  Image-guided therapy
  -  Light-based surgery

Selected Publications
Gather MC, Yun SH. Single-cell biological laser. Nature Photonics 5, 406-410 (2011) - Link

Kim P, Chung E, Yamashita H, Hung KE, Mizoguchi A, Kucherlapati R, Fukumura D, Jain RK, Yun SH. In vivo wide-area cellular imaging by side-view endomicroscopy. Nature Methods 7, 303-305 (2010). - Link

Fan Z, Spencer J, Yan Lu Y, Pitsillides CM, Singh G, Kim P, Yun SH, Strom TB, Lin CP, Koulmanda M. In vivo tracking of color coded effector, natural and induced regulatory T cells in allograft response. Nature Medicine 16, 718-722 (2010). - Link

Scarcelli S, Yun SH. “Confocal Brillouin microscopy for three-dimensional mechanical imaging,” Nature Photonics 2, 39-43 (2008) - Link.

Yun SH, Tearney GJ, Vakoc BJ, Shishkov M, Oh WY, Desjardins AE, Suter MJ, Chan RC, Evans JA, Jang IK, Nishioka NS, de Boer JF, Bouma BE. “Comprehensive volumetric optical microscopy in vivo.” Nature Medicine 12, 1429-33 (2006) - Link.

Dr. Yun is also an affiliated faculty member of the Harvard-MIT Division of Health Sciences and Technology (HST) and a Co-Director of HST Summer Institute for Biomedical Optics. If you are interested in Ph.D. or post-doctoral research opportunities, send an email to Dr. Yun with your CV at syun@hms.harvard.edu.

Research Projects