2014

Arany PR, Cho A, Hunt TD, Sidhu G, Shin K, Hahm E, Huang GX, Weaver J, Chen AC, Padwa BL, Hamblin MR, Barcellos-Hoff MH, Kulkarni AB, J Mooney D. Photoactivation of Endogenous Latent Transforming Growth Factor-β1 Directs Dental Stem Cell Differentiation for Regeneration. Sci Transl Med. 2014 May 28;6(238):238ra69. PMCID: PMC4113395 [Available on 2015/5/28]

Avci P, Gupta GK, Clark J, Wikonkal N, Hamblin MR. Low-level laser (light) therapy (LLLT) for treatment of hair loss. Lasers Surg Med. 2014 Feb;46(2):144-51. PMCID: PMC3944668 [Available on 2015/2/1]

de Sousa MV, Ferraresi C, de Magalhães AC, Yoshimura EM, Hamblin MR. Building, testing and validating a set of home-made von Frey filaments: A precise, accurate and cost effective alternative for nociception assessment. J Neurosci Methods. 2014 May 2;232C:1-5.

Gilaberte Y, Aspiroz C, Alejandre MC, Andres-Ciriano E, Fortuño B, Charlez L, Revillo MJ, Hamblin MR, Rezusta A. Cutaneous sporotrichosis treated with photodynamic therapy: an in vitro and in vivo study. Photomed Laser Surg. 2014 Jan;32(1):54-7. PMCID: PMC3887415 [Available on 2015/1/1]

Golberg A, Broelsch GF, Vecchio D, Khan S, Hamblin MR, Austen WG Jr, Sheridan RL, Yarmush ML. Pulsed Electric Fields for Burn Wound Disinfection in a Murine Model. J Burn Care Res. 2014 Aug 27. [Epub ahead of print]

Golberg A, Broelsch GF, Vecchio D, Khan S, Hamblin MR, Austen WG Jr, Sheridan RL, Yarmush ML. Eradication of multidrug-resistant A. baumannii in burn wounds by antiseptic pulsed electric field. Technology (Singap World Sci). 2014 Jun 1;2(2):153-160. PMCID: PMC4117356

Gupta A, Dai T, Hamblin MR. Effect of red and near-infrared wavelengths on low-level laser (light) therapy-induced healing of partial-thickness dermal abrasion in mice. Lasers Med Sci. 2014 Jan;29(1):257-65. PMCID: PMC3766381 [Available on 2015/1/1]

Hu Y, Huang X, Lu S, Hamblin MR, Mylonakis E, Zhang J, Xi L. Photodynamic Therapy Combined with Terbinafine Against Chromoblastomycosis and the Effect of PDT on Fonsecaea monophora In Vitro. Mycopathologia. 2014 Nov 1. [Epub ahead of print]

Huang L, Wang M, Dai T, Sperandio FF, Huang YY, Xuan Y, Chiang LY, Hamblin MR. Antimicrobial photodynamic therapy with decacationic monoadducts and bisadducts of [70]fullerene: in vitro and in vivo studies. Nanomedicine (Lond). 2014 Feb;9(2):253-66. PMCID: PMC3859801 [Available on 2015/2/1]

Huang YY, Nagata K, Tedford CE, Hamblin MR. Low-level laser therapy (810 nm) protects primary cortical neurons against excitotoxicity in vitro. J Biophotonics. 2014 Aug;7(8):656-64. PMCID: PMC4057365 [Available on 2015/8/1]

Jimenez JJ, Wikramanayake TC, Bergfeld W, Hordinsky M, Hickman JG, Hamblin MR, Schachner LA. Efficacy and Safety of a Low-level Laser Device in the Treatment of Male and Female Pattern Hair Loss: A Multicenter, Randomized, Sham Device-controlled, Double-blind Study. Am J Clin Dermatol. 2014 Apr;15(2):115-27. PMCID: PMC3986893

Kasimova KR, Sadasivam M, Landi G, Sarna T, Hamblin MR. Potentiation of photoinactivation of Gram-positive and Gram-negative bacteria mediated by six phenothiazinium dyes by addition of azide ion. Photochem Photobiol Sci. 2014 Oct 15;13(11):1541-8. PMCID: PMC4208731 [Available on 2015/10/15]

Naeser MA, Zafonte R, Krengel MH, Martin PI, Frazier J, Hamblin MR, Knight JA, Meehan WP 3rd, Baker EH. Significant improvements in cognitive performance post-transcranial, red/near-infrared light-emitting diode treatments in chronic, mild traumatic brain injury: open-protocol study. J Neurotrauma. 2014 Jun 1;31(11):1008-17. PMCID: PMC4043367 [Available on 2015/6/1]

Reginato E, Wolf P, Hamblin MR. Immune response after photodynamic therapy increases anti-cancer and anti-bacterial effects. World J Immunol 2014 March 27; 4(1): 1-11. PMCID: PMC4214901

Rineh A, Kelso MJ, Vatansever F, Tegos GP, Hamblin MR. Clostridium difficile infection: molecular pathogenesis and novel therapeutics. Expert Rev Anti Infect Ther. 2014 Jan;12(1):131-50.

Shrestha A, Hamblin MR, Kishen A. Photoactivated rose bengal functionalized chitosan nanoparticles produce antibacterial/biofilm activity and stabilize dentin-collagen. Nanomedicine. 2014 Apr;10(3):491-501. PMCID: PMC3966929 [Available on 2015/4/1]

Vecchio D, Bhayana B, Huang L, Carrasco E, Evans CL, Hamblin MR. Structure-function relationships of Nile blue (EtNBS) derivatives as antimicrobial photosensitizers. Eur J Med Chem. 2014 Mar 21;75:479-91. PMCID: PMC3970436 [Available on 2015/3/21]

Wachowska M, Gabrysiak M, Muchowicz A, Bednarek W, Barankiewicz J, Rygiel T, Boon L, Mroz P, Hamblin MR, Golab J. 5-Aza-2'-deoxycytidine potentiates antitumour immune response induced by photodynamic therapy. Eur J Cancer. 2014 May;50(7):1370-81.

Xuan W, Agrawal T, Huang L, Gupta GK, Hamblin MR. Low-level laser therapy for traumatic brain injury in mice increases brain derived neurotrophic factor (BDNF) and synaptogenesis. J Biophotonics. 2014 Sep 8;9999(9999).

Xuan W, Vatansever F, Huang L, Hamblin MR. Transcranial low-level laser therapy enhances learning, memory, and neuroprogenitor cells after traumatic brain injury in mice. J Biomed Opt. 2014 Oct 1;19(10):108003. PMCID: PMC4189010 [Available on 2015/10/7]

Yin R, Lin L, Xiao Y, Hao F, Hamblin MR. Combination ALA-PDT and ablative fractional Er:YAG laser (2,940 nm) on the treatment of severe acne. Lasers Surg Med. 2014 Mar;46(3):165-72. PMCID: PMC3961530 [Available on 2015/3/1]

Zhang Q, Zhou C, Hamblin MR, Wu MX. Low-level laser therapy effectively prevents secondary brain injury induced by immediate early responsive gene X-1 deficiency. J Cereb Blood Flow Metab. 2014 Aug;34(8):1391-401. PMCID: PMC4126101 [Available on 2015/8/1]

Zhang Y, Zhu Y, Gupta A, Huang Y, Murray CK, Vrahas MS, Sherwood ME, Baer DG, Hamblin MR, Dai T. Antimicrobial Blue Light Therapy for Multidrug-Resistant Acinetobacter baumannii Infection in a Mouse Burn Model: Implications for prophylaxis and treatment of combat-related wound infections. J Infect Dis. 2014 Jun 15;209(12):1963-71. PMCID: PMC4038138 [Available on 2015/6/15]

2013

Ando T, Sato S, Kobayashi H, Nawashiro H, Ashida H, Hamblin MR, Obara M. Low-level laser therapy for spinal cord injury in rats: effects of polarization. J Biomed Opt. 2013 Sep 1;18(9):98002. PMCID: PMC3771552 [Available on 2014/9/12]

Aquino AE Jr, Sene-Fiorese M, Paolillo FR, Duarte FO, Oishi JC, Pena AA Jr, Duarte AC, Hamblin MR, Bagnato VS, Parizotto NA. Low-level laser therapy (LLLT) combined with swimming training improved the lipid profile in rats fed with high-fat diet. Lasers Med Sci. 2013 Sep;28(5):1271-80. PMCID: PMC3594357

Assis L, Moretti AI, Abrahão TB, de Souza HP, Hamblin MR, Parizotto NA. Low-level laser therapy (808 nm) contributes to muscle regeneration and prevents fibrosis in rat tibialis anterior muscle after cryolesion. Lasers Med Sci. 2013 May;28(3):947-55. PMCID: PMC3516365

Avci P, Nyame TT, Gupta GK, Sadasivam M, Hamblin MR. Low-Level Laser Therapy for Fat Layer Reduction: A Comprehensive Review. Lasers Surg Med. 2013 Aug;45(6):349-57. PMCID: PMC3769994

Avci P, Sadasivam M, Gupta A, De Melo WC, Huang YY, Yin R, Rakkiyappan C, Kumar R, Otufowora A, Nyame T, Hamblin MR. Animal models of skin disease for drug discovery. Expert Opin Drug Discov. 2013 Mar;8(3):331-55. PMCID:PMC3580014

Avci P, Gupta A, Sadasivam M, Vecchio D, Pam Z, Pam N, Hamblin MR. Low-Level Laser (Light) Therapy (LLLT) in Skin: Stimulating, Healing, Restoring. Semin Cutan Med Surg 2013; 32:41-52.

Baxter RM, Dai T, Kimball J, Wang E, Hamblin MR, Wiesmann WP, McCarthy SJ, Baker SM. Chitosan dressing promotes healing in third degree burns in mice: gene expression analysis shows biphasic effects for rapid tissue regeneration and decreased fibrotic signaling. J Biomed Mater Res A. 2013 Feb;101(2):340-8. PMCID:PMC3488117

Chibebe Junior J, Fuchs BB, Sabino CP, Junqueira JC, Jorge AO, Ribeiro MS, Gilmore MS, Rice LB, Tegos GP, Hamblin MR, Mylonakis E. Photodynamic and Antibiotic Therapy Impair the Pathogenesis of Enterococcus faecium in a Whole Animal Insect Model. PLoS One. 2013;8(2):e55926-e55935. PMCID:PMC3573038

Chibebe Junior J, Sabino CP, Tan X, Junqueira JC, Wang Y, Fuchs BB, Jorge AO, Tegos GP, Hamblin MR, Mylonakis E. Selective photoinactivation of Candida albicans in the non-vertebrate host infection model Galleria mellonella. BMC Microbiol. 2013 Oct 1;13(1):217. PMCID: PMC3849975

Cury V, Moretti AI, Assis L, Bossini P, de Souza Crusca J, Neto CB, Fangel R, de Souza HP, Hamblin MR, Parizotto NA. Low level laser therapy increases angiogenesis in a model of ischemic skin flap in rats mediated by VEGF, HIF-1α and MMP-2. J Photochem Photobiol B. 2013 Aug 5;125:164-70. PMCID: PMC3759230

Dai T, Gupta A, Huang YY, Yin R, Murray CK, Vrahas MS, Sherwood ME, Tegos GP, Hamblin MR. Blue Light Rescues Mice from Potentially Fatal Pseudomonas aeruginosa Burn Infection: Efficacy, Safety, and Mechanism of Action. Antimicrob Agents Chemother. 2013 Mar;57(3):1238-45. PMCID: PMC3591931

Dai T, Gupta A, Huang YY, Sherwood ME, Murray CK, Vrahas MS, Kielian T, Hamblin MR. Blue Light Eliminates Community-Acquired Methicillin-resistant Staphylococcus aureus in Infected Mouse Skin Abrasions. Photomed Laser Surg. 2013 Nov;31(11):531-8. PMCID: PMC3818001 [Available on 2014/11/1]

De Melo WC, Lee AN, Perussi JR, Hamblin MR. Electroporation enhances antimicrobial photodynamic therapy mediated by the hydrophobic photosensitizer, hypericin. Photodiagnosis Photodyn Ther. 2013; 10:647—650. PMCID: PMC3889204 [Available on 2014/12/1]

de Melo WC, Avci P, de Oliveira MN, Gupta A, Vecchio D, Sadasivam M, Chandran R, Huang YY, Yin R, Perussi LR, Tegos GP, Perussi JR, Dai T, Hamblin MR. Photodynamic inactivation of biofilm: taking a lightly colored approach to stubborn infection. Expert Rev Anti Infect Ther. 2013 Jul;11(7):669-93.

G N, Tan A, Farhatnia Y, Rajadas J, Hamblin MR, Khaw PT, Seifalian AM. Channelrhodopsins: visual regeneration and neural activation by a light switch. N Biotechnol. 2013 Jun 25;30(5):461-74. PMCID: PMC3713181

Garcez AS, Núñez SC, Azambuja N Jr, Fregnani ER, Rodriguez HM, Hamblin MR, Suzuki H, Ribeiro MS. Effects of Photodynamic Therapy on Gram-Positive and Gram-Negative Bacterial Biofilms by Bioluminescence Imaging and Scanning Electron Microscopic Analysis. Photomed Laser Surg. 2013 Nov;31(11):519-25. PMCID: PMC3818004 [Available on 2014/11/1]

Gupta A, Avci P, Sadasivam M, Chandran R, Parizotto N, Vecchio D, de Melo WC, Dai T, Chiang LY, Hamblin MR. Shining light on nanotechnology to help repair and regeneration. Biotechnol Adv. 2013 Sep-Oct;31(5):607-31. PMCID: PMC3528806

Gupta A, Avci P, Dai T, Huang YY, Hamblin MR. Ultraviolet Radiation in Wound Care: Sterilization and Stimulation. Adv Wound Care (New Rochelle). 2013 Oct;2(8):422-437. Review. PMCID: PMC3797459

Hamblin MR. Can osteoarthritis be treated with light? Arthritis Res Ther. 2013 Oct 29;15(5):120. PMCID: PMC3978432

Huang YY, Vecchio D, Avci P, Yin R, Garcia-Diaz M, Hamblin MR. Melanoma resistance to photodynamic therapy: new insights. Biol Chem. 2013 Feb 1;394(2):239-50. PMCID:PMC3545031

Huang YY, Nagata K, Tedford CE, McCarthy T, Hamblin MR. Low-level laser therapy (LLLT) reduces oxidative stress in primary cortical neurons in vitro. J. Biophotonics. 2013 Oct;6(10):829-38. PMCID: PMC3651776 [Available on 2014/10/1]

Jeon S, Haley J, Flikkema J, Nalla V, Wang M, Sfeir M, Tan LS, Cooper T, Ji W, Hamblin MR, Chiang LY. Linear and Nonlinear Optical Properties of Photoresponsive [60]Fullerene Hybrid Triads and Tetrads with Dual NIR Two-Photon Absorption Characteristics. J Phys Chem C Nanomater Interfaces. 2013 Aug 20;117(33):17186-17195. PMCID: PMC3806628

Jeon S, Wang M, Tan LS, Cooper T, Hamblin MR, Chiang LY. Synthesis of Photoresponsive Dual NIR Two-Photon Absorptive [60]Fullerene Triads and Tetrads. Molecules. 2013 Aug 12;18(8):9603-22. PMCID: PMC3830959

Karimi M, Avci P, Mobasseri R, Hamblin MR, Naderi-Manesh H. The novel albumin-chitosan core-shell nanoparticles for gene delivery: preparation, optimization and cell uptake investigation. J Nanopart Res. 2013 Apr 1;15(4):1651. PMCID: PMC3868460

Kato IT, Prates RA, Sabino CP, Fuchs BB, Tegos GP, Mylonakis E, Hamblin MR, Ribeiro MS. Antimicrobial photodynamic inactivation inhibits Candida albicans virulence factors and reduces in vivo pathogenicity. Antimicrob Agents Chemother. 2013 Jan;57(1):445-51. PMCID:PMC3535901

Kokel D, Cheung CY, Mills R, Coutinho-Budd J, Huang L, Setola V, Sprague J, Jin S, Jin YN, Huang XP, Bruni G, Woolf CJ, Roth BL, Hamblin MR, Zylka MJ, Milan DJ, Peterson RT. Photochemical activation of TRPA1 channels in neurons and animals. Nat Chem Biol. 2013 Apr;9(4):257-63. PMCID: PMC3604056

Kourtesi C, Ball AR, Huang YY, Jachak SM, Vera DM, Khondkar P, Gibbons S, Hamblin MR, Tegos GP. Microbial efflux systems and inhibitors: approaches to drug discovery and the challenge of clinical implementation. Open Microbiol J. 2013;7:34-52. PMCID:PMC3617545

Lakshmanan S, Gupta GK, Avci P, Chandran R, Sadasivam M, Jorge AE, Hamblin MR. Physical Energy for Drug Delivery; Poration, Concentration and Activation. Adv Drug Deliv Rev. 2013 Jun 7. pii: S0169-409X(13)00148-8. PMCID: PMC3849347 [Available on 2014/12/7]

Mroz P, Vatansever F, Muchowicz A, Hamblin MR. Photodynamic therapy of murine mastocytoma induces specific immune responses against the cancer/testis antigen P1A. Cancer Res. 2013 Nov 1;73(21):6462-70. PMCID: PMC3831658 [Available on 2014/11/1]

Natasha G, Tan A, Farhatnia Y, Rajadas J, Hamblin MR, Khaw PT, Seifalian AM. Channelrhodopsins: vPMCID: PMC3582824 [Available on 2014/5/1] isual regeneration and neural activation by a light switch. N Biotechnol. 2013 Jun 25;30(5):461-74. PMCID: PMC3713181

Prates RA, Fuchs BB, Mizuno K, Naqvi Q, Kato IT, Ribeiro MS, Mylonakis E, Tegos GP, Hamblin MR. Effect of Virulence Factors on the Photodynamic Inactivation of Cryptococcus neoformans. PLoS One. 2013;8(1):e54387. PMCID:PMC3548784

Sadasivam M, Avci P, Gupta GK, Lakshmanan S, Chandran R, Huang YY, Kumar R, Hamblin MR. Self-assembled liposomal nanoparticles in photodynamic therapy. Eur J Nanomed. 2013 Jul;5(3). PMCID: PMC3857307

Sevgi M, Toklu A, Vecchio D, Hamblin MR. Topical Antimicrobials for Burn Infections - an Update. Recent Pat Antiinfect Drug Discov. 2013 Dec;8(3):161-97.

Sharma SK, Krayer M, Sperandio FF, Huang L, Huang YY, Holten D, Lindsey JS, Hamblin MR. Synthesis and evaluation of cationic bacteriochlorin amphiphiles with effective in vitro photodynamic activity against cancer cells at low nanomolar concentration. J. Porphyrins Phthalocyanines. 2013; 17: 73–85. PMCID: PMC3742135

Sperandio FF, Sharma SK, Wang M, Jeon S, Huang YY, Dai T, Nayka S, de Sousa SC, Chiang LY, Hamblin MR. Photoinduced electron-transfer mechanisms for radical-enhanced photodynamic therapy mediated by water-soluble decacationic C70 and C84O2 Fullerene Derivatives. Nanomedicine. 2013 May;9(4):570-9. PMCID: PMC3582824

Sperandio FF, Giudice FS, Correa L, Pinto Jr. D, Hamblin MR, de Sousa S C.O.M. Low-level laser therapy can produce increased aggressiveness of dysplastic and oral cancer cell lines by modulation of Akt/mTOR signaling pathway. J. Biophoton. 2013 Oct;6(10):839-47. PMCID: PMC3788041 [Available on 2014/10/1]

St Denis TG, Hamblin MR. Synthesis, bioanalysis and biodistribution of photosensitizer conjugates for photodynamic therapy. Bioanalysis. 2013 May;5(9):1099-114. PMCID: PMC3701389

St Denis TG, Dai T, Hamblin MR. Killing bacterial spores with blue light: when innate resistance meets the power of light. Photochem Photobiol. 2013 Jan-Feb;89(1):2-4. PMCID:PMC3556167

St Denis TG, Vecchio D, Zadlo A, Rineh A, Sadasivam M, Avci P, Huang L, Kozinska A, Chandran R, Sarna T, Hamblin MR. Thiocyanate Potentiates Antimicrobial Photodynamic Therapy: In Situ Generation of the Sulfur Trioxide Radical Anion by Singlet Oxygen. Free Radic Biol Med. 2013 Aug 19;65C:800-810. PMCID: PMC3889203 [Available on 2014/12/1]

Tan A, Farhatnia Y, Goh D, G N, de Mel A, Lim J, Teoh S-H, Malkovskiy AV, Chawla R, Rajadas J, Cousins BG, Hamblin MR, Alavijeh MS, Seifalian AM. Surface modification of a polyhedral oligomeric silsesquioxane poly(carbonate-urea) urethane (POSS-PCU) nanocomposite polymer as a stent coating for enhanced capture of endothelial progenitor cells. Biointerphases 2013 Dec;8(1):22. PMCID: PMC3979469

Tanaka M, Mroz P, Dai T, Huang L, Morimoto Y, Kinoshita M, Yoshihara Y, Shinomiya N, Seki S, Nemoto K, Hamblin MR. Linezolid and vancomycin decrease the therapeutic effect of methylene blue-photodynamic therapy in a mouse model of MRSA bacterial arthritis. Photochem Photobiol. 2013 May-Jun;89(3):679-82. PMCID: PMC3636181

Tegos GP, Hamblin MR. Disruptive innovations: new anti-infectives in the age of resistance. Curr Opin Pharmacol. 2013 Oct;13(5):673-677. PMCID: PMC3831660 [Available on 2014/10/1]

Vatansever F, Chandran R, Sadasivam M, Chiang LY, Hamblin MR. Multi-Functionality in Theranostic Nanoparticles: is more Always Better? J Nanomed Nanotechnol. 2012 Sep 24;3(8). pii: 120. No abstract available. PMCID: PMC3615455

Vatansever F, Ferraresi C, de Sousa MV, Yin R, Rineh A, Sharma SK, Hamblin MR. Can biowarfare agents be defeated with light? Virulence. 2013 Sep 25;4(8). Review. PMCID: PMC3925713

Vatansever F, de Melo WC, Avci P, Vecchio D, Sadasivam M, Gupta A, Chandran R, Karimi M, Parizotto NA, Yin R, Tegos GP, Hamblin MR. Antimicrobial strategies centered around reactive oxygen species - bactericidal antibiotics, photodynamic therapy, and beyond. FEMS Microbiol Rev. 2013 Nov;37(6):955-89. PMCID: PMC3791156 [Available on 2014/11/1]

Vatansever F, Rodrigues NC, Assis LL, Peviani SS, Durigan JL, Moreira FM, Hamblin MR, Parizotto NA. Low intensity laser therapy accelerates muscle regeneration in aged rats. Photonics Lasers Med. 2012 Oct 1;1(4):287-297. PMCID: PMC3671618

Vecchio D, Dai T, Huang L, Fantetti L, Roncucci G, Hamblin MR. Antimicrobial photodynamic therapy with RLP068 kills methicillin-resistant Staphylococcus aureus and improves wound healing in a mouse model of infected skin abrasion PDT with RLP068/Cl in infected mouse skin abrasion. J Biophotonics. 2013 Sep;6(9):733-42. PMCID: PMC3594622

Wang M, Maragani S, Huang L, Jean S, Canteenwala T, Hamblin MR, Chiang, LY. Synthesis of decacationic 1601 fullerene decaiodides giving photoinduced production of superoxide radicals and effective PDT-mediation on antimicrobial photoinactivation. Eur J Med Chem. 2013;63:170-84. PMCID: PMC3806655

Xia Y, Gupta GK, Castano AP, Mroz P, Avci P, Hamblin MR. CpG oligodeoxynucleotide as immune adjuvant enhances photodynamic therapy response in murine metastatic breast cancer. J Biophotonics. 2013 Aug 7. [Epub ahead of print] PMCID: PMC3917974 [Available on 2015/2/7]

Xuan W, Vatansever F, Huang L, Wu Q, Xuan Y, Dai T, Ando T, Xu T, Huang YY, Hamblin MR. Transcranial low-level laser therapy improves neurological performance in traumatic brain injury in mice: effect of treatment repetition regimen. PLoS One. 2013;8(1):e53454. PMCID:PMC3538543

Yang E, Diers JR, Huang YY, Hamblin MR, Lindsey JS, Bocian DF, Holten D. Molecular electronic tuning of photosensitizers to enhance photodynamic therapy: synthetic dicyanobacteriochlorins as a case study. Photochem Photobiol. 2013 May-Jun;89(3):605-18. PMCID: PMC3610834

Yin R, Dai T, Avci P, Jorge AE, de Melo WC, Vecchio D, Huang YY, Gupta A, Hamblin MR. Light based anti-infectives: ultraviolet C irradiation, photodynamic therapy, blue light, and beyond. Curr Opin Pharmacol. 2013 Oct;13(5):731-762. PMCID: PMC3831650 [Available on 2014/10/1]

Yin R, Wang M, Huang YY, Huang HC, Avci P, Chiang LY, Hamblin MR. Photodynamic therapy with decacationic [60]fullerene monoadducts: Effect of a light absorbing electron-donor antenna and micellar formulation. Nanomedicine. 2013 Dec 10. pii: S1549-9634(13)00679-5. PMCID: PMC4019724 [Available on 2015/5/1]

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2012

Apidianakis Y, Que YA, Xu W, Tegos GP, Zimniak P, Hamblin MR, Tompkins RG, Xiao W, Rahma LG. Down-regulation of glutatione S-transferase alpha 4 (hGSTA4) in the muscle of thermally injured patients is indicative of susceptibility to bacterial infection. FASEB J. 2012 Feb;26(2):730-7. PMCID: PMC3290433

Assis L, Moretti AI, Abrahão TB, de Souza HP, Hamblin MR, Parizotto NA. Low-level laser therapy (808 nm) contributes to muscle regeneration and prevents fibrosis in rat tibialis anterior muscle after cryolesion. Lasers Med Sci. 2012 Nov;44(9):726-35.

Chung H, Dai T, Sharma SK, Huang YY, Carroll JD, Hamblin MR. The Nuts and Bolts of Low-level Laser (Light) Therapy. Ann Biomed Eng. 2012 Feb;40(2):516-33. PMCID: PMC3288797

Dai T, Gupta A, Murray CK, Vrahas MS, Tegos GP, Hamblin MR. Blue light for infectious diseases: Propionibacterium acnes, Helicobacter pylori, and beyond? Drug Resist Updat. 2012 Aug;15(4):223-36. PMCID: PMC3438385

Dai T, Garcia B, Murray CK, Vrahas MS, Hamblin MR. UVC Light Prophylaxis for Cutaneous Wound Infections in Mice. Antimicrob Agents Chemother. 2012 Jul;56(7):3841-8. PMCID: PMC3393382

Dai T, Vrahas MS, Murray CK, Hamblin MR. Ultraviolet C irradiation: an alternative antimicrobial approach to localized infections? Expert Rev Anti-Infect Ther. 2012; 10(2):185-95. PMCID: PMC3292282

Dai T, Fuchs BB, Coleman JJ, Prates RA, Astrakas C, St.Denis TG, Ribeiro MS, Mylonakis E, Hamblin MR, Tegos GP. Concepts and principles of photodynamic therapy as an alternative antifungal discovery platform. Front. Microbio. 2012 April;3(120). PMCID: PMC3322354

Dai T, Murray CK, Vrahas MS, Baer DG, Tegos GP, Hamblin MR. Ultraviolet C light for Acinetobacter baumannii wound infections in mice: Potential use for battlefield wound decontamination? J Trauma Acute Care Surg. 2012 Sep;73(3):661-667. PMCID: PMC3463377

Demidova-Rice TN, Hamblin MR, Herman IM. Acute and Impaired Wound Healing: Pathophysiology and Current Methods for Drug Delivery, Part 1: Normal and Chronic Wounds: Biology, Causes, and Approaches to Care. Adv Skin Wound Care. 2012 Jul;25(7):304-314.

Demidova-Rice TN, Hamblin MR, Herman IM. Acute and Impaired Wound Healing: Pathophysiology and Current Methods for Drug Delivery, Part 2: Role of Growth Factors in Normal and Pathological Wound Healing: Therapeutic Potential and Methods of Delivery. Adv Skin Wound Care. 2012 Aug;25(8):349-370. PMCID: PMC3428147

Demidova-Rice TN, Wolf L, Deckenback J, Hamblin MR, Herman IM. Human Platelet-Rich Plasma- and Extracellular Matrix-Derived Peptides Promote Impaired Cutaneous Wound Healing In Vivo. PLoS ONE. 2012;7(2):e32146. PMCID: PMC3285658

Ferrarasi C, Hamblin MR, Parizotto NA. Low-level laser (light) therapy (LLLT) on muscle tissue: performance, fatigue and repair benefited by the power of light. Photon Lasers Med. 2012; 1(4):267-286. PMCID: PMC3635110

García-Díaz M, Kawakubo M, Mroz P, Sagristà ML, Mora M, Nonell S, Hamblin MR. Cellular and vascular effects of the photodynamic agent temocene are modulated by the delivery vehicle. J Control Release. 2012 Jul 27;162(2):355-363. PMCID: PMC3438332

Hamblin MR. Antimicrobial Photodynamic Therapy and Photodynamic Inactivation, or Killing Bugs with Dyes and Light-A Symposium-in-Print. Photochem Photobiol. 2012 May-Jun;88(3):496-8.

Hamrahi V, Hamblin MR, Jung W, Benjamin JB, Paul KW, Fischman AJ, Tompkins RG, Carter EA. Gram-Negative Bacterial Infection in Thigh Abscess Can Migrate to Distant Burn Depending on Burn Depth. Interdiscip Perspect Infect Dis. 2012; 2012: 567140. PMCID: PMC3412104

Huang L, Xuan Y, Koide Y, Zhiyentayev T, Tanaka M, Hamblin MR. Type I and type II mechanisms of antimicrobial photodynamic therapy: An in vitro study on Gram-negative and Gram-positive bacteria. Lasers Surg Med. 2012 Aug;44(6):490-9. PMCID:PMC3428129

Huang L, St Denis TG, Xuan Y, Huang YY, Tanaka M, Zadlo A, Sama T, Hamblin MR. Paradoxical potentiation of methylene blue-mediated antimicrobial photodynamic inactivation by sodium azide: Role of ambient oxygen and azide radicals. Free Radic Biol Med. 2012 Dec 1;53(11):2062-71. PMCID: PMC3522421

Huang YY, Balasubramanian T, Yang E, Luo D, Diers JR, Bocian DF, Lindsey JS, Holten D, Hamblin MR. Stable Synthetic Bacteriochlorins for Photodynamic Therapy: Role of Dicyano Peripheral Groups, Central Metal Substitution (2H, Zn, Pd), and Cremophor EL Delivery. ChemMedChem. 2012 Dec;7(12):2155-67. PMCID: PMC3519240

Huang YY, Gupta A, Vecchio D, Arce VJ, Huang SF, Xuan W, Hamblin MR. Transcranial low level laser (light) therapy for traumatic brain injury. J Biophotonics. 2012 Nov;5(11-12):827-37.

Huang YY, Sharma SK, Dai T, Chung H, Yaroslavsky A, Garcia-Diaz M, Chang J, Chiang LY, Hamblin MR. Can Nanotechnology Potentiate Photodynamic Therapy? Nanotech Rev. 2012;1(2):111-46.

Huang YY, Tanaka M, Vecchio D, Garcia-Diaz M, Chang J, Morimoto Y, Hamblin MR. Photodynamic therapy induces an immune response against a bacterial pathogen. Expert Rev Clin Immunol. 2012 Jul;8(5):479-94. PMCID: PMC3506647

Kawakubo M, Eguchi K, Arai T, Kobayashi K, Hamblin MR. Surface layer-preserving photodynamic therapy (SPPDT) in a subcutaneous mouse model of lung cancer. Lasers Surg Med. 2012 2012 Aug;44(6):500-7. PMCID: PMC3428124

Li P, Zhou G, Zhu X, Li G, Yan P, Shen L, Xu Q, Hamblin MR. Photodynamic therapy with hyperbranched poly(ether-ester) chlorin(e6) nanoparticles on human tongue carcinoma CAL-27 cells. Photodiagnosis Photodyn Ther. 2012 Mar;9(1):76-82. PMCID: PMC3292741

Penjweini R, Loew HG, Hamblin MR, Kratky KW. Long-term monitoring of live cell proliferation in presence of PVP-Hypericin: a new strategy using ms pulses of LED and the fluorescent dye CFSE. J Microsc. 2012 Jan;245(1):100-8. PMCID: PMC3232286

Sharma SK, Mroz P, Dai T, Huang YY, St Denis TG, Hamblin MR. Photodynamic Therapy for Cancer and for Infections: What Is the Difference? Isr J Chem. 2012 Sep;52(8-9):691-705. PMCID: PMC3522418

Shrestha A, Hamblin MR, Kishen A. Characterization of a Conjugate between Rose Bengal and Chitosan for Targeted Antibiofilm and Tissue Stabilization Effects as a Potential Treatment of Infected Dentin. Antimicrob Agents Chemother. 2012 Sep;56(9):4876-84. PMCID: PMC3421904

Tanaka M, Kinoshita M, Yoshihara Y, Shinomiya N, Seki S, Nemoto K, Hirayama T, Dai T, Huang L, Hamblin MR, Morimoto Y. Optimal Photosensitizers for Photodynamic Therapy of Infections Should Kill Bacteria but Spare Neutrophils. Photochem Photobiol. 2012 Jan;88(1):227-232. PMCID: PMC3253242

Tanaka M, Mroz P, Dai T, Huang L, Morimoto Y, Kinoshita M, Yoshihara Y, Nemoto K, Shinomiya N, Seki S, Hamblin MR. Photodynamic Therapy Can Induce a Protective Innate Immune Response against Murine Bacterial Arthritis via Neutrophil Accumulation. PLoS One. 2012;7(6):e39823. PMCID: PMC3383702

Thota S, Wang M, Jeon S, Maragani S, Hamblin MR, Chiang LY. Synthesis and characterization of positively charged pentacationic [60]fullerene monoadducts for antimicrobial photodynamic inactivation. Molecules. 2012 May 7;17(5):5225-43. PMCID: PMC3361754

Vatansever F, Chandran R, Sadasivam M, Chiang LY, Hamblin MR. Multi-Functionality in Theranostic Nanoparticles: is more Always Better? J Nanomedic Nanotechnol 2012 Sep 24;3(8). pii: 120. PMCID:PMC3615455

Vatansever F, Hamblin MR. Far infrared radiation (FIR): its biological effects and medical applications. Photonics Lasers Med. 2012 Nov 1;4:255-266. PMCID: PMC3699878

Vatansever F, Rodrigues NC, Assis LL, Peviani SS, Durigan JL,. Moreira FA, Hamblin MR, Parizotto NA. Low intensity laser therapy accelerates muscle regeneration in aged rats. Photon Lasers Med. 2012;1(4):287-297.

Vera DM, Haynes MH, Ball AR, Dai DT, Astrakas C, Kelso MJ, Hamblin MR, Tegos GP. Strategies to potentiate antimicrobial photoinactivation by overcoming resistant phenotypes(†). Photochem Photobiol. 2012 May-Jun;88(3):499-511. PMCID: PMC3345078

Wang M, Huang L, Sharma SK, Jeon S, Thota S, Sperandio FF, Nayka SN, Chang J, Hamblin MR, Chiang LY. Synthesis and Photodynamic Effect of New Highly Photostable Decacationically Armed [60]- and [70]Fullerene Decaiodide Monoadducts to Target Pathogenic Bacteria and Cancer Cells. J Med Chem. 2012 May 10;55(9):4274-85. PMCID: PMC3351079

Wu Q, Xuan W, Ando T, Xu T, Huang L, Huang YY, Dai T, Dhital S, Sharma SK, Whalen MJ, Hamblin MR. Low-level laser therapy for closed-head traumatic brain injury in mice: effect of different wavelengths. Lasers Surg Med. 2012 Mar;44(3):218-26. PMCID: PMC3397203

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2011

Agostinis P, Berg K, Cengel KA, Foster TH, Girotti AW, Gollnick SO, Hahn SM, Hamblin MR, Juzeniene A, Kessel D, Korbelik M, Moan J, Mroz P, Nowis D, Piette J, Wilson BC, Golab J. Photodynamic therapy of cancer: An update. CA Cancer J Clin. 2011 Jul-Aug;61(4):250-81. PMCID: PMC3209659

Ando T, Xuan W, Xu T, Dai T, Sharma SK, Kharkwal GB, Huang YY, Wu Q, Whalen MJ, Sato S, Obara M, Hamblin MR. Comparison of Therapeutic Effects between Pulsed and Continuous Wave 810-nm Wavelength Laser Irradiation for Traumatic Brain Injury in Mice. PLoS One. 2011; 6(10): e26212. PMCID: PMC3196530

Chen AC, Arany P, Huang YY, Tomkinson EM, Sharma SK Kharkwal GB, Saleem T, Mooney D, Yull FE, Blackwell TS, Hamblin MR. Low-level laser therapy activates NF-kB via generation of reactive oxygen species in mouse embryonic fibroblasts. PLoS ONE, 2011, 6 (7) e22453. PMCID: PMC3141042

Chen AC, Huang YY, Sharma SK, Hamblin MR. Effects of 810-nm Laser on Murine Bone-Marrow-Derived Dendritic Cells. Photomed Laser Surg. 2011 Jun;29(6):383-9. PMCID: PMC3105346

Dai T, Bil de Arce VJ, Tegos GP, Hamblin MR. Blue dye and red light: a dynamic combination for prophylaxis and treatment of cutaneous Candida albicans infections in mice. Antimicrob Agents Chemother. 2011 Dec;55(12):5710-7. PMCID: PMC3232820

Dai T, Kharkwal GB, Zhao J, Denis TG, Wu Q, Xia Y, Huang L, Sharma SK, d'Enfert C, Hamblin MR. Ultraviolet-C Light for Treatment of Candida albicans Burn Infection in Mice. Photochem Photobiol. 2011 Mar-Apr;87(2):342-9. PMCID: PMC3048910

Dai T, Tegos GP, St. Denis TG, Anderson D, Sinofsky E, Hamblin, MR. Ultraviolet-C Irradiation for Prevention of Central Venous Catheter Related Infections: An In-vitro Study. Photochem Photobiol. 2011 Jan-Feb;87(1):250-5. PMCID: PMC3010268

Dai T, Tanaka M, Huang YY, Hamblin MR. Chitosan preparations for wounds and burns: antimicrobial and wound healing effects. Expert Rev Anti-Infect Ther. 2011, 9(7):857-879. PMCID: PMC3188448

Dai T, Kharkwal GB, Tanaka M, Huang YY, Bil de Arce VJ, Hamblin MR. Animal models of external traumatic wound infections. Virulence. 2011. 2:(4), 296-315. PMCID: PMC3173676

Fiamegos YC, Kastritis PL, Exarchou V, Han H, Bonvin MJ, Vervoot J, Lewis K, Hamblin MR, Tegos GP. Antimicrobial and efflux pump inhibitory activity of caffeoylquinic acids from Artemisia absinthium against Gram-positive pathogenic bacteria. PLoS ONE, 2011, 6(4): e18127. PMCID: PMC3070693

Garcez AS, Núñez SC, Baptista MS, Daghastanli NA, Itri R, Hamblin MR, Ribeiro MS. Antimicrobial mechanisms behind photodynamic effect in the presence of hydrogen peroxide. Photochem Photobiol Sci. 2011 Apr 30;10(4):483-90. PMCID: PMC3069140

Hamblin MR. Reply to "Championing Photoantimicrobial Discovery". Photodiagn Photodyn Ther. 2011.

Huang L, Dai T, Xuan Y, Tegos GP, Hamblin MR. Synergistic combination of chitosan acetate with nanoparticle silver as a topical antimicrobial: efficacy against bacterial burn infections. Antimicrob Agents Chemother. 2011, Jul;55(7):3432-8. PMCID: PMC3122390. Featured in http://www.mdlinx.com/nurse-practitioner/news-article.cfm/3646304.

Huang L, Zhiyentayev T, Xuan Y, Azhibek D, Kharkwal GB, Hamblin MR. Photodynamic inactivation of bacteria using polyethylenimine-chlorin(e6) conjugates: Effect of polymer molecular weight, substitution ratio of chlorin(e6) and pH. Lasers Surg Med. 2011 Apr;43(4):313-23. PMCID: PMC3449165

Huang YY, Sharma SK, Carroll JD, Hamblin MR. Biphasic dose response in low-level light therapy - An update. Dose Response Journal. 2011; 9(4): 602-618. PMCID: PMC3315174

Kharkwal GB, Sharma SK, Huang YY, Dai T, Hamblin MR. Photodynamic Therapy for Infections: Clinical Applications. Lasers Surg Med, 2011 43:755-767. PMCID: PMC3449167

Mizuno K, Zhiyentayev T, Huang L, Khalil1 S, Nasim F, Tegos GP, Gali H, Jahnke A, Wharton T, Hamblin MR. Antimicrobial photodynamic therapy with functionalized fullerenes: Quantitative structure-activity relationships. J Nanomedic Nanotechnol 2011, 2:2. PMCID: PMC3130518

Mroz P, Hamblin MR. The immunosuppressive side of PDT. Photochem Photobiol Sci. 2011 May 1;10(5):751-8. PMCID: PMC3441049

Mroz P, Xia Y, Asanuma D, Konopko A, Zhiyentayev T, Huang YY, Sharma SK, Dai T, Khan UJ, Wharton T, Hamblin MR. Intraperitoneal photodynamic therapy mediated by a fullerene in a mouse model of abdominal dissemination of colon adenocarcinoma. Nanomedicine. 2011 Dec;7(6):965-74. PMCID: PMC3183379

Mroz P, Hashmi JT, Huang YY, Lange N, Hamblin MR. Stimulation of anti-tumor immunity by photodynamic therapy. Expert Rev Clin Immunol. 2011 Jan;7(1):75-91. PMCID: PMC3060712

Mroz P, Yaroslavsky A, Kharkwal GB Hamblin MR. Cell Death Pathways in Photodynamic Therapy of Cancer. Cancers 2011. 3, 2516-2539. PMCID: PMC3729395

Naeser MA, Hamblin MR. Potential for Transcranial Laser or LED Therapy to Treat Stroke, Traumatic Brain Injury, and Neurodegenerative Disease. Photomed Laser Surg. 2011, 29(7); 443-446. PMCID: PMC3128319

Naeser MA, Saltmarche A, Krengel MH, Hamblin MR, Knight JA. Improved Cognitive Function After Transcranial, Light-Emitting Diode Treatments in Chronic, Traumatic Brain Injury: Two Case Reports. Photomed Laser Surg. 2011. May;29(5):351-8. PMCID: PMC3104287. Reviewed in http://topnews.us/content/237119-transcranial-light-therapy-may-help-tbi-patients.

Prates RA, Kato IT, Ribeiro MS, Tegos GP, Hamblin MR. Influence of multidrug efflux systems on methylene blue-mediated photodynamic inactivation of Candida albicans. J Antimicrob Chemother. 2011 Jul;66(7):1525-32. PMCID: PMC3112030

Sharma SK, Dai T, Kharkwal GB, Huang YY, Huang L, De Arce VJ, Tegos GP, Hamblin MR. Drug Discovery of Antimicrobial Photosensitizers using Animal Models. Curr Pharm Des. 2011;17(13):1303-19. Review. PMCID: PMC3463379

Sharma SK, Chiang LY, Hamblin MR. Photodynamic therapy with fullerenes in vivo: reality or a dream? Nanomedicine (Lond). 2011 Dec;6(10):1813-25. PMCID: PMC3433279

Sharma SK, Kharkwal GB, Sajo M, Huang YY, De Taboada L, McCarthy T, Hamblin MR. Dose response effects of 810-nm laser-light on mouse primary cortical neurons. Lasers Surg Med. 2011 Sep;43(8):851-9. PMCID: PMC3199299

St Denis TG, Huang L, Dai T, Hamblin MR. Analysis of the Bacterial Heat Shock Response to Photodynamic Therapy-mediated Oxidative Stress. Photochem Photobiol. 2011 2011 May-Jun;87(3):707-13. PMCID: PMC3082629

St Denis TG, Aziz K, Waheed AA, Huang YY, Sharma SK, Mroz P, Hamblin MR. Combination approaches to potentiate immune response after photodynamic therapy for cancer. Photochem Photobiol Sci, 2011 May 1;10(5):792-801. PMCID: PMC3449163

St Denis TG, Dai T, Izikson A, Astrakas C, Anderson RR, Hamblin MR, Tegos GP. All you need is light. Antimicrobial photoinactivation as an evolving and emerging discovery strategy against infectious disease. Virulence. 2011 Nov 1;2(6):509-20. PMCID: PMC3260545

Tanaka M, Kinoshita M, Yoshihara Y, Shinomiya N, Seki S, Nemoto K, Hamblin MR, Morimoto Y. Photodynamic therapy using intra-articular photofrin for murine MRSA arthritis: Biphasic light dose response for neutrophil-mediated antibacterial effect. Lasers Surg Med. 2011 Mar;43(3):221-9. PMCID: PMC3071702

Wainwright M, Dai T, Hamblin MR. Antimicrobial photodynamic therapy in the colon: delivering a light punch to the guts? Photochem Photobiol. 2011 Jul-Aug;87(4):754-6. PMCID: PMC3132272

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2010

Chen Z, Zhou S, Chen J, Deng Y, Luo Z, Chen H, Hamblin MR, Huang M. Pentalysine b-Carbonylphthalocyanine Zinc: An Effective Tumor-Targeting Photosensitizer for Photodynamic Therapy. ChemMedChem, 2010 Jun 7;5(6):890-8. PMCID: PMC2935799

Chiang LY, Padmawar PA, Rogers-Haley JE, So G, Canteenwala T, Thota S, Tan LS, Pritzker K, Huang YY, Sharma SK, Kurup DB, Hamblin, MR. Wilson BC, Urbas A. Synthesis and characterization of highly photoresponsive fullerenyl dyads with a close chromophore antenna–C60 contact and effective photodynamic potential. J Mater Chem. 2010 Jan 1;20(25):5280-5293. PMCID: PMC2947801

Coleman JJ, Okoli I, Tegos GP, Holson E, Wagner FF, Hamblin MR, Mylonakis E. Characterization of plant-derived saponin natural products against Candida albicans. ACS Chem Biol, 2010 Mar 19;5(3):321-32. PMCID: PMC2965462

Dai T, Tegos GP, Zhiyentayev T, Mylonakis E, Hamblin MR. Photodynamic Therapy for Methicillin-Resistant Staphylococcus aureus Infection in a Mouse Skin Abrasion Model. Lasers Surg Med. 2010 January; 42(1): 38. PMCID: PMC2820267

Dai T, Huang YY, Sharma SK, Hashmi JT, Kurup DB Hamblin MR. Topical Antimicrobials for Burn Wound Infections. Recent Patents on Anti-Infective Drug Discovery, 2010 Jun 1;5(2):124-51. PMCID: PMC2935806

Garcez AS, Nunez SC, Hamblin MR, Suzuki H, Ribeiro MS. Photodynamic therapy associated with conventional endodontic treatment in patients with antibiotic resistant microflora. A preliminary report. J Endod. 2010; 36(9): 1463-1466.

Hamblin, MR. Introduction to Experimental and Clinical Studies Using Low-Level Laser (Light) Therapy (LLLT). Lasers Surg Med. 2010 Aug;42(6):447-9. PMCID: PMC2939452

Hamblin MR, Dai T. Can surgical site infections be treated by photodynamic therapy? Photodiagnosis Photodyn Ther. 2010 June; 7(2): 134–136. PMCID: PMC2945525

Hashmi JT, Huang Y-Y, Sharma SK, Kurup DB, De Taboada L, Carroll JD, Hamblin MR. Effect of pulsing in low-level light therapy. Laser Surg Med, 2010, 42:450-466. PMCID: PMC2933784

Hashmi JT, Huang YY, Osmani BZ, Sharma SK, Naeser MA, Hamblin MR. Role of Low-Level Laser Therapy in Neurorehabilitation. Physical Medicine and Rehabilitation 2010;2:S292-S305. PMCID: PMC3065857

Huang L, Dai T, Hamblin MR. Antimicrobial photodynamic inactivation and photodynamic therapy for infections. Methods Mol Biol. 2010;635:155-73. PMCID: PMC2933785

Huang L, Terakawa M, Zhiyentayev T, Huang YY, Sawayama Y, Jahnke A, Tegos GP, Wharton T, Hamblin MR. Novel cationic fullerenes as broad-spectrum light-activated antimicrobials. Nanomedicine. 2010 Jun;6(3):442-52. PMCID: PMC2879475

Huang L, Huang YY, Mroz P, Tegos GP, Zhiyentayev T, Sharma SK, Lu Z, Balasubramanian T, Krayer M, Ruzié C, Yang E, Kee HL, Kirmaier C, Diers JR, Bocian DF, Holten D, Lindsey JS, Hamblin MR. Stable Synthetic Cationic Bacteriochlorins As Selective Antimicrobial Photosensitizers. Antimicrob Agents Chemother, 2010, 54; 3834-3841. PMCID: PMC2934952

Huang YY, Mroz P, Zhiyentayev T, Sharma SK, Balasubramanian T, Ruzié C, Borbas KE, Fan D, Krayer M, Yang E, Kee HL, Kirmaier C, Diers JR, Bocian DF, Holten D, Lindsey JS, Hamblin MR. In Vitro Photodynamic Therapy and Quantitative Structure-Activity Relationship Studies with Stable Synthetic Near-Infrared-Absorbing Bacteriochlorin Photosensitizers. J Med Chem, 2010 May 27;53(10):4018-27. PMCID: PMC2933425

Huang L, Terakawa M, Zhiyentayev T, Huang YY, Sawayama Y, Jahnke A, Tegos GP, Wharton T, Hamblin MR. Innovative cationic fullerenes as broad-spectrum light-activated antimicrobials. Nanomedicine. 2010 Jun;6(3):442-52. PMCID: PMC2879475

Kishen A, Upadya M, Tegos GP, Hamblin MR. Efflux Pump Inhibitor Potentiates Antimicrobial Photodynamic Inactivation of Enterococcus faecalis Biofilm. Photochem Photobiol 2010 Nov-Dec;86(6):1343-9. PMCID: PMC2991588

Lu Z, Dai T, Huang L, Kurup DB, Tegos GP, Jahnke A, Wharton T, Hamblin, MR. Photodynamic therapy with a cationic functionalized fullerene rescues mice from fatal wound infections. Nanomedicine (Lond). 2010 Dec;5(10):1525-33. PMCID: PMC3047412

Mroz P, Huang YY, Szokalska A, Zhiyentayev T, Janjua S, Nifli AP,. Sherwood ME, Ruzié C, Borbas KE, Fan D, Krayer M, Balasubramanian T, Yang E, Kee HL, Kirmaier C, Diers JR, Bocian DF, Holten D, Lindsey JS, Hamblin MR. Stable synthetic bacteriochlorins overcome the resistance of melanoma to photodynamic therapy. FASEB J. 2010 Sep;24(9):3160-70. PMCID: PMC2934952

Mroz P, Szokalska A, Wu MX, Hamblin MR. Photodynamic Therapy of Tumors Can Lead to Development of Systemic Antigen-Specific Immune Response. PLoS ONE 2010, 5(12): e15194. PMCID: PMC3001867

Park J, Mroz P, Salomatina  E, Hamblin MR, Yaroslavsky  AN. Dye-enhanced multimodal confocal microscopy for noninvasive detection of skin cancers in mouse models. J Biomed Optics, 2010, 15(2), 026023. PMCID: PMC2866259

Ragas X, Dai T, Tegos GP, Agut M, Nonell S, Hamblin MR. Photodynamic inactivation of Acinetobacter baumannii using phenothiazinium dyes: in-vitro and in-vivo studies. Lasers Surg Med; 2010 Jul;42(5):384-90. PMCID: PMC2935797

Ragàs X, Sánchez-García D, Ruiz-Gonzalez R, Dai T, Agut M, Hamblin MR, Nonell S. Cationic Porphycenes as Potential Photosensitizers for Antimicrobial Photodynamic Therapy. J Med Chem 2010 Nov 11;53(21):7796-803. PMCID: PMC2981434

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2009

Dai T, Huang YY, Hamblin MR. Photodynamic therapy for localized infections--state of the art. Photodiagnosis Photodyn Ther. 2009 Sep-Dec;6(3-4):170-88. PMCID: PMC2811240

Dai T, Tegos GP, Lu Z, Huang L, Zhiyentayev T, Franklin MJ, Baer DG, Hamblin MR. Photodynamic therapy for Acinetobacter baumannii burn infections in mice. Antimicrob. Agents Chemother. 2009 53: 3929-3934. PMCID: PMC2737832

Dai T, Tegos GP, Burkatovskaya M, Castano AP, Hamblin MR. Chitosan acetate bandage as a topical antimicrobial dressing for infected burns. Antimicrob Agents Chemother 2009 Feb;53(2):393-400. PMCID: PMC2630614

George S, Hamblin MR, Kishen A. Uptake pathways of anionic and cationic photosensitizers into bacteria. Photochem Photobiol Sci 2009. 8, 788-795. PMCID: PMC2797759

Huang Y-Y, Chen A C-H, Carroll JD. Hamblin MR. Biphasic dose response in low-level light therapy. Dose Response, 2009, 7, 358-383. PMCID: PMC2790317

Lembo AJ, Ganz RA , Sheth S, Cave D, Kelly C, Levin P, Kazlas PT, Baldwin PC III, Lindmark WR, McGrath JR, Hamblin MR. Treatment of Helicobacter pylori Infection with Intra-Gastric Violet Light Phototherapy - a Pilot Clinical Trial. Lasers Surg Med. 2009. 41(5):337-344. PMCID: PMC2841969

Mroz P, Bhaumik J, Dogutan DK, Aly Z, Kamal Z, Khalid J, Kee HK, Bocian DF, Holten D, Lindsey JS and Hamblin MR. Imidazole metalloporphyrins as photosensitizers for photodynamic therapy: Role of molecular charge, central metal and hydroxyl radical production. Cancer Lett 2009, 282:63-76. PMCID: PMC2782654

Schiffer F, Johnston AL. Polcari A, Teicher MH, Webb RH, Hamblin MR. Psychological benefits 2 and 4 weeks after a single treatment with near infrared light to the forehead: A pilot study of 10 patients with major depression and anxiety. Behavioral Brain Res. 2009, 5, 46-55. PMCID: PMC2796659

Szokalska A, Makowski M, Nowis D, Wilczynski GM, Kujawa M, Wójcik C, Mlynarczuk-Bialy I, Salwa P, Bil J, Janowska S, Agostinis P, Verfaillie T, Bugajski M, Gietka J, Issat T, Glodkowska E, Mrówka P, Stoklosa T, Hamblin MR , Mróz P, Jakóbisiak M, Golab J. Proteasome inhibition potentiates antitumor effects of photodynamic therapy in mice through induction of ER stress and unfolded protein response. Cancer Res. 2009. 69(10):4235-43. PMCID: PMC2785802

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2008

Burkatovskaya M, Castaño AP, Demidova-Rice T Tegos GP, Hamblin MR. Effect of chitosan acetate bandage on wound healing in infected and noninfected wounds in mice. Wound Rep Reg 2008;16:425-431. PMCID: PMC2805166

Castaño AP, Mroz P, Wu MX, Hamblin MR. Photodynamic therapy plus low-dose cyclophosphamide generates antitumor immunity in a mouse model. Proc Natl Acad Sci U S A 2008 Apr 8;105(14):5495-500. PMCID: PMC2291083

Dai T, Tegos GP, Rolz-Cruz G, Cumbie WE, Hamblin MR. Ultraviolet C inactivation of dermatophytes: implications for treatment of onychomycosis. Brit J Dermatol 2008;158:1239-1246. PMCID: PMC2808700

Garcez, AS, Nunez SC, Hamblin MR, and Ribeiro MS. Antimicrobial effects of photodynamic therapy on patients with necrotic pulps and periapical lesion. J Endodont 2008, 34:138-142. PMCID: PMC2808698

Kee HL, Bhaumik J, Diers JR, Mroz P, Hamblin MR, Bocian DF, Lindsey JS, Holten D. Photophysical characterization of imidazolium-substituted Pd(II), In(III), and Zn(II) porphyrins as photosensitizers for photodynamic therapy. J Photochem Photobiol A 2008;200:346-355. PMCID: PMC2615400

Tawakol A, Castano AP, Gad F, Zahra T, Bashian G, Migrino RQ, Ahmadi A, Stern J, Anatelli F, Chirico S, Shirazi A, Syed S, Fischman AJ, Muller JE, and Hamblin MR. Intravascular detection of inflamed atherosclerotic plaques with a scavenger receptor-targeted fluorescent photosensitizer. Photochem Photobiol Sci 2008, 7, 33-39. PMCID: PMC2813573

Tegos GP, Masago K, Aziz F, Higginbotham A, Stermitz FR, Hamblin MR. Inhibitors of bacterial multidrug efflux pumps potentiate antimicrobial photoinactivation. Antimicrob Agents Chemother 2008 September; 52(9): 3202–3209. PMCID: PMC2533468

Wang XL, Wang HW, Hillemanns P, Hamblin MR. Distinctive features of foreskin condylomata acuminata associated with diabetes mellitus. Acta Derm Venereol 2008;88(6):578-83. PMCID: PMC2808699

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2007

Apidianakis Y, Mindrinos MN, Xiao W, Tegos GP, Papisov MI, Hamblin MR, Davis RW, Tompkins RG, Rahme LG. Involvement of Skeletal Muscle Gene Regulatory Network in Susceptibility to Wound Infection Following Trauma. PLoS ONE. 2007; 2(12): e1356. PMCID: PMC2131783

Castano AP, Dai T, Yaroslavsky I, Cohen R, Apruzzese AW, Smotrich MH, Hamblin MR. Low-level laser therapy for zymosan-induced arthritis in rats: Importance of illumination time. Lasers Surg Med 2007;39(6):543-550. PMCID: PMC2935792

Demidova-Rice TN, Salomatina EV, Yaroslavsky AN, Herman IM, Hamblin MR. Low-level light stimulates excisional wound healing in mice. Lasers Surg Med 2007;39(9):706-715. PMCID: PMC2935798

Fuchs, BB, Tegos GP, Hamblin MR, and Mylonakis E. Susceptibility of Cryptococcus neoformans to photodynamic inactivation Is associated with cell wall integrity. Antimicrob Agents Chemother 2007;51(8):2929-36. PMCID: PMC1932496

Garcez AS, Nunez SC, Lage-Marques JL, Hamblin MR, Ribeiro MS. Photonic real-time monitoring of bacterial reduction in root canals by genetically engineered bacteria after chemomechanical endodontic therapy. Braz Dent J 2007;18(3):202-7.

Garcez, AS; Ribeiro MS, Tegos GP, Nunez SC, Jorge AO, Hamblin MR. Antimicrobial photodynamic therapy combined with conventional endodontic treatment to combat root canal infection. Lasers Surg Med 2007;39(1):59-66.

Moller-Kristensen M, Hamblin MR, Thiel S, Jensenius JC, Takahashi K. Burn Injury reveals altered phenotype in Mannan-Binding lectin-deficient mice. J Invest Dermatol 2007;127:1524-1531. PMCID: PMC2936508

Mroz P, Pawlak A, Satti M, Lee H, Wharton T, Gali H, Sarna T and Hamblin MR. Functionalized fullerenes mediate photodynamic killing of cancer cells: Type I versus Type II photochemical mechanism. Free Radical Biol Med 2007;43(5):711-9. PMCID: PMC1995806

Mroz P, Tegos GP, Gali H, Wharton T, Sarna T, Hamblin MR. Photodynamic therapy with fullerenes. Photochem Photobiol Sci 2007;6:1139-1149. PMCID: PMC2933422

Tang HM, Hamblin MR, Yow, CM. A comparative in vitro photoinactivation study of clinical isolates of multidrug-resistant pathogens. J Infect Chemother 2007;13(2):87-91. PMCID: PMC2933783

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2006

Anatelli F, Mroz P, Liu Q, Yang C, Castano AP, Swietlik E, Hamblin MR. Macrophage-targeted photosensitizer conjugate delivered by intratumoral injection. Mol Pharm 2006;3(6):654-664. PMCID: PMC2504868

Borbas KE, Mroz P, Hamblin MR, and Lindsey JS. Bioconjugatable porphyrins bearing a compact swallowtail motif for water solubility. Bioconj Chem 2006;17:638-653. PMCID: PMC3072562

Burkatovskaya M, Tegos GP, Swietlik E, Demidova TN, P Castano A, Hamblin MR. Use of chitosan bandage to prevent fatal infections developing from highly contaminated wounds in mice. Biomaterials 2006;27(22):4157-4164. PMCID: PMC2935802

Castaño AP, Liu Q, and Hamblin MR. A green fluorescent protein-expressing murine tumour but not its wild-type counterpart is cured by photodynamic therapy. Brit J Cancer 2006;94:391-397. PMCID: PMC2361144

Castaño AP, Mroz P, and Hamblin MR. Photodynamic therapy and anti-tumour immunity. Nat Rev Cancer 2006;6:535-545. PMCID: PMC2933780

Foley JW, Song X, Demidova TN, Jilal F, Hamblin MR. Synthesis and properties of benzo[a]phenoxazinium chalcogen analogs as novel broad-spectrum antimicrobial photosensitizers. J Med Chem 2006;49:5291-5299. PMCID: PMC3071243

Møller-Kristensen M, Shi L, Ip E, Gowda LD, Hamblin MR, Thiel S, Jensenius JC, Ezekowitz RA, Takahashi K. Deficiency of mannose-binding lectin greatly increases susceptibility to post-burn infection with Pseudomonas aeruginosa. J Immunol 2006;176(3):1769-1775. PMCID: PMC3071691

Tawakol A, Castano AP, Anatelli F, Bashian G, Stern J, Zahra T, Gad F, Chirico S, Ahmadi A, Fischman AJ, Muller JE, Hamblin MR. Photosensitizer delivery to vulnerable atherosclerotic plaque: comparison of macrophage-targeted conjugate versus free chlorin(e6). J Biomed Optics 2006;11:210-218. PMCID: PMC2936819

Tegos GP, Hamblin MR. Phenothiazinium antimicrobial photosensitizers are substrates of bacterial multidrug resistance pumps. Antimicrob Agents Chemother 2006;50:196-203. PMCID: PMC1346798

Tegos GP, Anbe M, Yang C, Demidova TN, Satti M, Mroz P, Janjua S, Gad F and Hamblin MR. Protease stable polycationic photosensitizer conjugates between polyethyleneimine and chlorin(e6) for broad spectrum antimicrobial photoinactivation. Antimicrob Agents Chemother 2006;50:1402-1410. PMCID: PMC1426948

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2005

Castaño AP, Demidova TN, Hamblin MR. Mechanisms in photodynamic therapy: part two - cellular signaling, cell metabolism and modes of cell death. PPT 2005;2:1-23.

Castaño AP, Demidova TN, Hamblin MR. Mechanisms in photodynamic therapy: part three - Photosensitizer pharmacokinetics, biodistribution, tumor localization and modes of tumor destruction. PPT 2005;2:91-106.

Demidova TN, Hamblin MR. Effect of cell-photosensitizer binding & cell density on microbial photoinactivation. Antimicrob Agents Chemother 2005;49(6):2329-35.

Demidova TN, Gad F, Zahra T, Francis KP, Hamblin MR. Monitoring photodynamic therapy of localized infections by bioluminescence imaging of genetically engineered bacteria. J Photochem Photobiol B 2005;81:15-25. PMCID: PMC3071690

Demidova TN, Hamblin MR. Photodynamic inactivation of Bacillus spores, mediated by phenothiazinium dyes. Appl Environ Microb 2005;71(11):6918-25. PMCID: PMC1287731

Ganz RA, Viveiros J, Ahmad A, Ahmadi A, Khalil A, Tolkoff MJ, Nishioka NS, Hamblin MR. Helicobacter pylori in patients can be killed by visible light. Laser Surg Med 2005;36(4):260-5. PMCID: PMC3071042

Hamblin MR, Viveiros J, Yang C, Ahmadi A, Ganz RA, Tolkoff MJ. Heliobacter pylori accumulates photoactive porphyrins and is killed by visible light. Antimicrob Agents Chemother 2005;49(7):2822-7. PMCID: PMC1168670

Lambrechts SA, Demidova TN, Aalders MC, Hasan T, Hamblin MR. Phtodynamic therapy for Staphylococcus aureus infected burn wounds in mice. Photochem Photobiol 2005;4:503-9. PMCID: PMC3071043

Liu Q, Hamblin MR. Macrophage-targeted photodynamic therapy: scavenger receptor expression and activation state. Int J Immunopath Pharmacol 2005;18:391-402.

Tegos GP, Demidova TN, Arcilla-Lopez D, Wharton T, Hariprased G, Hamblin MR. Cationic fullerenes are effective and selective antimicrobial photosensitizers. Chem Biol 2005;12:1127-35. PMCID: PMC3071678

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2004

Castaño AP, Demidova TN, Hamblin MR. Mechanisms in photodynamic therapy: part one - photosensitizers, photochemistry and cellular localization. Photodiag Photo Ther 2004;1:279-93.

Demidova TN, Hamblin MR. Macrophage-targeted photodynamic therapy. Int J Immunopathol Pharmacol 2004;17(2):117-26.

Demidova TN, Hamblin MR. Photodynamic therapy targeted to pathogens. Int J Immunopathol Pharmacol 2004;17(3):245-54.

Gad F, Zahra T, Hasan T, Hamblin MR. Effects of growth phase and extracellular slime on photodynamic inactivation of gram-positive pathogenic bacteria. Antimicrob Agents Chemother 2004;48(6):2173-8. PMCID: PMC415578

Gad F, Zahra T, Francis K, Hasan T, Hamblin MR. Targeted photodynamic therapy of established soft-tissue infections in mice. Photochem Photobiol Sci 2004;3(5):451-458. PMCID: PMC3071693

Hamblin MR, Hasan T. Photodynamic therapy: a new antimicrobial approach to infectious disease? Photochem Photobiol Sci 2004;3(5):436-50. PMCID: PMC3071049

Khadem JJ, Martino M, Anatelli F, Dana MR, Hamblin MR. Healing of perforating rat corneal incisions closed with photodynamic laser-activated tissue glue. Lasers Surg Med 2004;35(4):304-11. PMCID: PMC3071689

Shi L, Takahashi K, Dundee J, Shahroor-Karni S, Thiel S, Jensenius JC, Gad F, Hamblin MR, Sastry KN, Ezekowitz RAB. Mannose-binding lectin-deficient mice are susceptible to infection with staphylococcus aureus. J Exp Med 2004;199(10):1379-90. PMCID: PMC2211809

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2003

Hamblin MR, Miller JL, Rizvi I, Loew HG, Hasan T. Pegylation of charged polymer-photosensitizer conjugates: effects on photodynamic efficacy. Br J Cancer 2003; 89:937-943.

Hamblin MR, Zahra T, Contag CH, McManus AT, Hasan T. Optical monitoring and treatment of potentially lethal wound infections in-vivo. J Infect Dis 2003; 187:1717-1725.

Kodama T, Doukas AG, Hamblin MR. Delivery of ribosome-inactivating protein toxin into cancer cells with shock waves. Cancer Lett 2003; 189:69-75.

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2002

Hamblin MR, O'Donnell DA, Murthy N, Contag CH, Hasan T. Rapid control of wound infections by targeted photodynamic therapy monitored by In-vivo bioluminescence imaging. Photochem Photobiol 2002; 75(1):51-57.

Hamblin MR, O'Donnell DA, Murthy N, Rajagopalan K, Michaud N, Sherwood ME, Hasan T. Polycationic photosensitizer conjugates: effects of chain length and Gram classification on the photodynamic inactivation of bacteria. J Antimicrob Chemoth 2002; 49:941-951.

Hamblin MR, Miller JL, Rizvi I, Ortel B. Degree of substitution of chlorin(e6) conjugated to charged poly-L-lysine chains affects their cellular uptake, localization and phototoxicity towards macrophages and cancer cells. J X-ray Sci Tech May 2002; 10:139-152.

Hamblin MR. Covalent photosensitizer conjugates for targeted photodynamic therapy. Trends in Photochem Photobiol 2002; 9:1-24.

Kodama T, Doukas AG, Hamblin MR. Shock wave-mediated molecular delivery into cells. Biochem Biophys Acta 2002; 1542:186-194.

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2001

Hamblin MR, Miller JL, Rizvi I, Ortel B, Maytin EV, Hasan T. Pegylation of a chlorine6 polymer conjugate increases tumor targeting of photosensitizer. Cancer Res 2001; 61:7155-7162.

Soukos NS, Hamblin MR, Keel S, Fabian RL, Deutsch TF, Hasan T. Epidermal growth factor receptor-targeted immunophotodiagnosis and photoimmunotherapy of oral precancer in-vivo. Cancer Res 2001; 61:4490-4496.

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2000

Del Governatore M, Hamblin MR, Piccinini EE, Ugolini G, Hasan T. Targeted photodestruction of human colon cancer cells using charged 17.1a chlorine6 immunoconjugates. Br J Cancer 2000; 82:56-64.

Del Governatore M, Hamblin MR, Shea CR, Rizvi I, Molpus KL, Tanabe KK, Hasan T. Experimental photoimmunotherapy of hepatic metastases of colorectal cancer with a 17.1A chlorine6 immunoconjugate. Cancer Res 2000; 60:4200-4205.

Hamblin MR, Miller JL, Ortel B. Scavenger-receptor targeted photodynamic therapy. Photochem Photobiol 2000; 72:533-540.

Hamblin MR, Del Governatore M, Rizvi I, Hasan T. Biodistribution of charged 17.1A photoimmunoconjugates in a murine model of hepatic metastasis of colorectal cancer. Br J Cancer 2000; 83:1544-1551.

Kodama T, Hamblin MR, Doukas AG. Cytoplasmic molecular delivery with shock waves: importance of impulse. Biophys J 2000; 79:1821-1832.

Molpus KL, Hamblin MR, Rizvi I, Hasan T. Intraperitoneal photoimmunotherapy of ovarian carcinoma xenografts in nude mice using charged photoimmunoconjugates. Gynecol Oncol 2000; 76:397-404.

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