IV tPA Administration for Adult Patients Arriving Within 3 Hours.
Comments in brackets denote activities specific to MGH, or additional commentary
regarding national standards or guidelines. For example:
Prior to making any medical decisions, please view our disclaimer.
These are based on FDA approved labeling of alteplase.
Contraindications include any of the following:
These conditions may increase the risk of unfavorable outcomes but are not necessarily a contraindication to treatment:
*For extended window IV thrombolysis (3.0-4.5 hours from last seen well), additional relative exclusion criteria exist:
Calculate the exact dose of t-PA using the t-PA Dosing Calculator
if patient's weight is known or measured. If estimating weight to 10 lb intervals, the
Dosing Sheet below may be used.
View sheet (PDF)
Reviewed/Approved by: Rost, Natalia, M.D., M.P.H. on behalf of ASQT
Last updated: 1/16/2015
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