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Eptifibatide (Integrilin) Dosing Form

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  Description and Instructions   Pharmacokinetics:
  • Glycoprotein 2b3a inhibitor (blocks platelet aggregation)
  • Use 0.75 mg/ml stock solution from pharmacy
  • Bolus with 90 mcg/kg followed by 0.5-2.0 mcg/kg/min infusion
  • Continue IV for a maximum of 72 hours
  • Switch to aspirin 325 mg po qd and/or plavix 75 mg po qd
  • No (chemical) measure of direct action available
  • 85% inhibition of platelet aggregation post bolus
  • Elimination half-life 2.5 hrs
  • Steady state 4-6 hours
  • > 90% inhibition at steady state
  • 4 hrs after d/c drug, platelet inhibition drops to < 50%
Weight (lbs) Weight (kg) Bolus Dose (cc) at 90 mcg/kg Low-dose Infusion (ml/hr) Hi-dose Infusion (ml/hr)
280
270
260
250
240
230
220
210
200
190
180
170
160
150
140
130
120
110
100
127.3
122.7
118.2
113.6
109.1
104.5
100.0
95.5
90.9
86.4
81.8
77.3
72.7
68.2
63.6
59.1
54.5
50.0
45.5
15.3
14.7
14.2
13.6
13.1
12.5
12.0
11.5
10.9
10.4
9.8
9.3
8.7
8.2
7.6
7.1
6.5
6.0
5.5
5
5
5
5
4
4
4
4
4
3
3
3
3
3
3
2
2
2
2
20
20
19
18
17
17
16
15
15
14
13
12
12
11
10
9
9
8
7

Authoring Information

Reviewed/Approved by: Nogueira, Raul Gomes, M.D.

Last reviewed: 7/7/2010

Last updated: 7/7/2010

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