IV Unfractionated Heparin Dosing

Intensity

Indications and dosing

Low:

Neuro: Suspected or proven embolic stroke without high risk of stroke progression

Bolus:

none

Initial Infusion:

12 units/kg/hr to a max of 1,200 units/hr

Target PTT:

50-70 seconds

Lab:

Check PTT 6 hours after bolus or after any rate change

Standard:

Neuro: Cerebral venous sinus thrombosis or strokes at risk for progression. These include critical large vessel stenosis (carotid, basilar or MCA) or patients with fluctuating ischemic symptoms. Consider lower theriputic range if large areas of infarction present or any ICH.

Bolus:

80 units/kg IV up to a max of 5,000 units

Initial Infusion:

12 units/kg/hr to a max of 1,200 units/hr for normal body habitus and 1,800 units/hr for morbid obesity

Target PTT:

50-70 or 60-84 seconds

Lab:

Check PTT 6 hours after bolus or after any rate change

High:

Peripheral Venous Thrombosis: DVT, PE

Consider lower theraputic range if large areas of infarction present or any ICH.

Bolus:

80 units/kg IV up to a max of 7,500

Initial Infusion:

18 units/kg/hr max dose of 1800 units/hr

Target PTT:

60-84 seconds

Lab:

Check PTT 6 hours after bolus or after any rate change

Other:

Indication and dosing at Provider Discretion