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Faculty
Daphne J. Holt, MD, PhD
dholt@partners.org
Dr. Daphne Holt is a junior faculty member of the Massachusetts General Hospital Psychiatry Department, an Instructor at Harvard Medical School, and Associate Director of the MGH First Episode and Early Psychosis Program.
Dr. Holt graduated magna cum laude from Brown University with a BA in biochemistry. She attended medical school at the University of Chicago Pritzker School of Medicine where she also received a PhD in neurobiology. For her PhD thesis she conducted studies of the molecular and cellular composition of the corpus striatum in the normal human brain and in the disorder of schizophrenia. She then received training in clinical psychiatry in the Massachusetts General/McLean Hospital adult psychiatry residency program, during which she served as an administrative Chief Resident. During her training she received numerous awards including the NIMH Outstanding Resident Award and the Laughlin Merit Award. She completed a two-year fellowship in psychiatric neuroimaging at MGH.
Currently Dr. Holt continues to pursue her long-standing interest in the neurobiological basis of psychosis. She is particularly focused on understanding abnormalities in emotional perception that may give rise to psychotic symptoms such as delusions. She uses the techniques of functional magnetic resonance imaging, electroencephalography, and affective/cognitive neuroscience to test hypotheses about the neural circuits that produce normal and aberrant emotional responses. She has published peer-reviewed articles in basic neuroscience journals such as Neuroscience and TheJournal of Comparative Neurology as well as in psychiatric journals such as the Harvard Review of Psychiatry, Biological Psychiatry and Schizophrenia Research. Her research has been supported by the Clinical Investigator Training Program (Harvard/MIT Health Sciences and Technology- BIDMC, in collaboration with Pfizer, Inc), the Dupont-Warren Fellowship, GlaxoSmithKline Severe Mental Illness Award, the Jerome Lyle Rappaport Charitable Foundation and the Institute for Mental Illness and Neuroscience Discovery (MIND).
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