Dr. Pitteloud is a faculty member with Reproductive Endocrine Associates at the Massachusetts General Hospital and an Instructor at Harvard Medical School. Her area of expertise is human reproduction, with a specific focus on male infertility.

Her research projects concentrate on the role of the hormone FSH in testicular development and spermatogenesis in the male. This work involves the study of GnRH deficient men in whom the onset and timing of pubertal development can be controlled. In this large cohort of patients, she has determined the predictors of outcome of long term pulsatile GnRH. She has also helped develop new biological markers (inhibin B and Mullerian Inhibitory Substance) as potentially useful surrogate markers of Sertoli and germ cell number and maturation. She is currently involved in genetic investigations examining genotype/phenotype correlation in patients with GnRH deficiency.

Her clinical practice covers the spectrum of reproductive endocrinology-- including polycystic ovarian syndrome, infertility, and menopause. She has expertise in ovulation induction with clomiphene and gonadotropins. As previously described in her research interests, she also has extensive experience in the field of male hypogonadism.

Selected Publications:

• N. Pitteloud, K. Binz, A. Caulfield, J. Philippe. Ketoacidosis during gestational
diabetes. Diabetes Care, 1998;21:1031-1032

• N. Pitteloud, J. Philippe. Risque coronarien chez les diabétiques: effets préventifs des statines. Med et Hyg 1998; 56:529-536

• N. Pitteloud, J. Philippe. Characteristics of Caucasian type 2 diabetic patient during ketoacidosis and at follow-up. Schweiz Med Wochensch 2000; 130:576-582

• Pitteloud N, Boepple PA, DeCruz S, Valkenburgh SB, Crowley WF,Jr, Hayes FJ. The Fertile Eunuch variant of idiopathic hypogonadotropic hypogonadism: spontaneous reversal associated with a homozygous mutation in the GnRH receptor. J Clin Endocrinol Metab 2001, 86:2470-2475

• Beranova M, Oliveira LMB, Bedecarrats G, Schipani E, Vallejo M, Ammini P, Quitos JB, Hall JE, Martin KA, Hayes FJ, Pitteloud N, Kaiser U, Crowley Jr WF, Seminara SB. Incidence, spectrum, and modes of inheritance of GnRH receptor mutations in idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab 2001;86:1580-1587

• Hayes FJ, Pitteloud N, DeCruz S, Crowley WF Jr, Boepple PA. Importance of Inhibin B in the Regulation of FSH Secretion in the Human Male. J Clin Endocrinol Metab. 2001; 86:5541-6

• Pitteloud N, Hayes FJ, Boepple PA, DeCruz S, Seminara SB, MacLaughlin DT, Crowley WF, Jr. The role of prior pubertal development, biochemical markers of testicular maturation, and genetics in elucidating the phenotypic heterogeneity of idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab 2002; 87:152-160

• Pitteloud N, Hayes FJ, Dwyer A, Crowley, WF Jr, Predictors of outcome of long-term GnRH therapy in men with idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab 2002; 87:4128

• Pitteloud N, Dwyer A, Crowley WF, MJ McPhaul, Hayes FJ, Acute stress masking the biochemical phenotype of partial insensitivity syndorme in a subject with a novel mutation in the androgen receptor. J Clin Endocrinol Metab. Submitted