Dr. Sluss' research laboratory has been focusing on the role of a small molecular weight inhibitor in FSH inhibition of its binding to its receptor, the putative role of this inhibitor in premature ovarian failure, and the physiology of follistatin in the regulation of FSH biosynthesis and secretion.

In addition, Dr. Sluss runs the Radioimmunoassay Core of the Reproductive Endocrine Sciences Center.

Dr. Sluss has determined the presence and charted the course of a small molecular weight inhibitor of FSH binding to its receptor that appears to be produced within the human follicle, caused premature ovarian failure in selected numbers of patients, and is related to anchoring proteins on the cell surface of granulosa cells.This small molecular weight inhibitor competes with the binding of FSH for its receptor inhibition and thereby causes resistance to FSH via this mechanism.

Dr. Sluss is currently determining the hormonal regulation, physiology of this inhibitor across the human menstrual cycle as well as in various disease processes, and its role in other species. Dr. Sluss is a Center Investigator in the Reproductive Endocrine Sciences Center.