Dr. Martin is a faculty member of the Reproductive Endocrine Unit, an Assistant Professor in Medicine at Harvard Medical School, and Co-Director of the Reproductive Endocrine Associates, the Unit's Group Practice.

She has active teaching and clinical roles in the Unit, and her main clinical interest is in the area of menopause and hormone replacement therapy. Dr. Martin has lectured extensively at MGH, Harvard Medical School, and at national meetings and postgraduate courses on this topic.

Dr. Martin has also directed our group practice, the Reproductive Endocrine Associates, for the past 13 years. In addition to menopause, her other areas of clinical interest include menstrual cycle disorders, polycystic ovary syndrome, and infertility. Her teaching role includes assuming responsibility for much of the clinical training in reproductive endocrinology of the first year endocrinology fellows, post-doctoral fellows who choose to do their subspecialty training in our Unit, and rotating medical house officers. The success and uniqueness of the Reproductive Endocrine Unit's practice was recently highlighted by an invitation by the Journal of Clinical Endocrinology and Metabolism to publish it as a model of an academic/clinical investigative practice. Dr. Martin was the senior author of this publication in recognition of her importance in its function as well as its didactic and scholarly activities.

Despite Dr. Martin's busy clinical and teaching roles, she continues to make major contributions to clinical investigation within our Unit. She has published the only large study comparing efficacy and safety of two types of therapies (including pulsatile GnRH, a therapy pioneered in the REU) for inducing ovulation in women with infertility. More recently, Kathryn was the senior author on two important papers that defined the biochemical abnormalities and natural history of women with hypothalamic amenorrhea (lack of periods due to weight loss, eating disorders, or heavy exercise).

Selected Publications:

• Martin KA, Hall JE, Adams JM, Crowley Jr WF. Comparison of exogenous
gonadotropins and pulsatile GnRH for induction of ovulation in
hypogonadotropic amenorrhea (HA). J Clin Endocrinol Metab 1993; 77:125-9.

• Seminara SB, Hall JE, Taylor AE, Crowley Jr WF, Martin KA. The
Reproductive Endocrine Associates of Massachusetts General Hospital:
fifteen years of integrated practice and investigation. J Clin Endocrinol
Metab. 84:1912-1918, 1999.

• Perkins RB, Hall JE, Martin KA. Neuroendocrine Abnormalities in
Hypothalamic Amenorrhea: Spectrum, Stability, and Response to
Neurotransmitter Modulation. J Clin Endocrinol Metab 1999; 84:1905-1911.

• Martin KA, Hornstein MD, Taylor AE, Hall JE, Barbieri RL. Exogenous
Gonadotropin Stimulation is Associated With Increases in Serum Androgens
in IVF-ET Cycles Fertil Steril 1997;68:1011-16.

• Martin KA, Welt CK, Smith JA, Crowley WF Jr., Hall JE. Is GnRH Reduced at
the Midcycle Surge in the Human?: Evidence From a GnRH-Deficient Model.
Neuroendocrinology 1998; 67:363-369.

• Manson JE, Martin KA. Postmenopausal hormone replacement therapy:
Navigating the maze to rational use. N Engl J Med 2001; 345:34.

• Perkins RB, Hall JE, Martin KA. Aetiology, previous menstrual function and
patterns of neuro-endocrine disturbance as prognostic indicators in
hypothalamic amenorrhoea. Human Reproduction 2001; 16:2198.

• BoAbbas Y, Martin KA, Liberman RF, Cramer DW, Barbieri RL. Serum and
follicular hormone levels during in vitro fertilization after short or long course GnRH

• Hall JE, Lavoie HB, Marsh EE, Martin KA. Decrease in GnRH pulse frequency with aging in postmenopausal women. J Clin Endocrinol Metab 2000;85:1794-1800.

• Martin KA. Hormone Replacement Therapy. In: Endocrinology Rounds. From the Endocrine Division, Massachusetts General Hospital. June 2003; Volume 2, Issue 6. Snell Medical Communication, Inc.