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The Reproductive Endocrine Unit of the Massachusetts General Hospital has a long history of research focusing on understanding the mechanisms of reproduction. Several outpatient and inpatient studies are currently underway in normal men and women and in patients with disorders of the reproductive system. All studies have been carefully reviewed and approved by the Partners Institutional Review Board.

Below is a list of all Reproductive Endocrine studies currently recruiting study participants, along with basic qualifications for participating.

If you believe you qualify and are interested in enrolling in any research study, click on the title below for more details and contact information. We look forward to hearing from you!

 

 

FEMALE SUBJECTS MALE SUBJECTS

Aging and the Brain. Postmenopausal, age either 45-55 or 69-80, and on no hormone replacement.

Role of Gonadotropin Pulsations in the Reversal of Hypogonadotropic Hypogonadism. Seeking men 18 and older with IHH (idiopathic hypogonadotropic hypogonadism).
Aging, Estrogens and the Brain. Postmenopausal, age either 45-55 or 69-80, and on no hormone replacement. Role of FSH in Human Gonadal Development. Seeking men 18 and older with Hypogonadotropic hypogonadism (HH). The aim of this study is to better understand the specific roles of FSH, LH, and T in reproduction while trying to maximize the potential for fertility in men with HH.
Hormones in Caucasian and African-American Women. 18 to 35 years old with regular menstrual cycles; on no birth control pills. Feedback Control of FSH Secretion in the Human Male. The purpose of the research study is to learn more about the regulation of reproductive hormones in adult men. Three groups of men between 18 and 50 years of age will be studied in this project: agonadal men (a lack of testicular function), GnRH deficient men (men who lack GnRH and have low hormone levels), and healthy normal men (who have had a normal timing of puberty and normal hormone levels).
Molecular Basis of Inherited Reproductive Disorders. Individuals with early, delayed or absent pubertal development qualify for participation in this study. We are also interested in individuals that experience a change in their reproductive system later in life, for example loss of fertility. Participation of family members is optional but encouraged. Molecular Basis of Inherited Reproductive Disorders. Individuals with early, delayed or absent pubertal development qualify for participation in this study. We are also interested in individuals that experience a change in their reproductive system later in life, for example loss of fertility. Participation of family members is optional but encouraged.
Hormones in the Ovary. Caucasian or African-American woman, 18 to 45 years old, with regular menstrual cycles; on no birth control pills.

Effect of Varying Testsosterone Levels on Insulin Sensitivity in Normal and IHH Men. The purpose of this research study is to determine if changing testosterone levels in men will result in changes in insulin sensitivity. We are seeking men 18-75 who do not have diabetes to participate in this research study.

Polycystic Ovarian Syndrome. Women with or without PCOS, age 18-40. Women with PCOS should be off medications, including birth control, for at least 3 months. Women with regular menstrual cycles should have monthly periods and not be on any medications, including birth control pills. Effect of Increasing Testosterone Levels on Insulin Sensitivity in Men with the Metabolic Syndrome. The metabolic syndrome is a medical condition defined by high cholesterol levels, high blood pressure, increased abdominal obesity (gain in fat around the region of the stomach), and insulin resistance. We are looking for men between the ages of 50-75 with the metabolic syndrome to participate in this research study.
Recombinant Human Prolactin for Mothers with Pituitary Problems and Prolactin Deficiency. Mothers with prolactin deficiency from previous pituitary surgery, radiation, Sheehan’s syndrome or unknown causes will receive recombinant human prolactin to induce lactation. Must be 18-45; not taking oral contraceptives or have had previous breast surgery. Effects of 7 Days of Exogenous Pulsatile GnRH Treatment on the Pituitary Gonadal Axis in Hypogonadotropic Hypogonadal Subjects (7 Day Study of GnRH Treatment). The purpose of the research study is to replace GnRH and examine the response of the pituitary (a gland in the brain) to the treatment. Seeking men 18 and older with IHH.
Recombinant Human Prolactin Treatment for Lactation Insufficiency in Mothers of Premature Infants. Seek mothers of premature infants who are pumping breast milk but have an insufficient milk supply. Must be 18-45, and may not be taking oral contraceptives or have had previous breast surgery.

Interplay Between Gonadal Steroids and Insulin Sensitivity in Men. The purpose of this research study is to identify the relationship between testosterone levels and insulin sensitivity in men. Insulin sensitivity relates to how your body processes sugar. We are seeking men between the ages of 40-65 to participate inthis study. Men may be normal weight, obese, or have type 2 diabetes.

Reproductive Hormones. 18 and 35 years old with regular menstrual cycles; on no birth control pills.  

 

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