Dr. Hall is Professor of Medicine at Harvard Medical School, Associate Physician in Medicine at the Massachusetts General Hospital, Associate Chief of the Reproductive Endocrine Unit and has just completed a three-year term as the first Vice-President for Clinical Research of the Endocrine Society.
Dr. Hall’s research focuses on the neuroendocrine interactions underlying normal human reproduction and the changes that occur both with aging and in clinical disorders of ovulation.
Critical to progress in this area is the use of indirect techniques to gain access to information about the neuroendocrine control of reproduction. To accomplish this, Dr. Hall has developed and used a combination of clinical investigative approaches and models to investigate the complex interactions of the hypothalamic, pituitary and gonadal components of the reproductive axis. These have included the use of GnRH receptor blockers as physiologic probes, the use of sleep and circadian protocols, and most recently the use of positron emission tomography (PET).
Her recent studies of the physiology and pathophysiology of the menstrual cycle have focused on FSH secretion, which is critical to normal reproduction. This work has helped to define the physiology of inhibin A and inhibin B relative to that of estradiol in young and older reproductive aged women.
Dr. Hall’s studies have provided increasing evidence that in the human, there are dramatic hypothalamic and pituitary changes, which occur in aging and may contribute to the menopause. Her studies have indicated that the sensitivity to estrogen negative feedback at the hypothalamic level is preserved with aging. Her current studies are addressing the effects of aging at the pituitary level in women and are using PET scans to determine the sites of estrogen negative and positive feedback in women.
Dr. Hall is continuing to study the use of pulsatile GnRH in anovulatory infertility. Conception rates are high in patients with hypothalamic amenorrhea and acquired hypogonadotropic hypogonadism, while the risks of multiple gestation and hyperstimulation are lower than with alternative therapies. The importance of controlling the risk of multiple gestation is emphasized in studies in which she has demonstrated the profound economic impact of this complication of ovulation induction. Current studies are addressing the social impact of multiple gestation and infertility treatment.
A recipient of the A. Clifford Barger Excellence in Mentoring Award from Harvard Medical School, Dr. Hall is a clinical investigator who is actively involved in training students, fellows and young investigators. [Click here to view a listing of her former trainees.] Her work is supported by R01 grants from the NIH and as well as a Midcareer Award in Patient-Oriented Research from the NIH. In addition, she has an active clinical practice with a particular interest in menstrual cycle abnormalities (such as polycystic ovarian syndrome, premature menopause, hypothalamic amenorrhea), as well as infertility and menopause. She has extensive experience with the use of clomiphene, gonadotropins and pulsatile GnRH for ovulation induction in women with anovulatory disorders and unexplained infertility.
• Srouji SS, Pagan YL, D’Amato F, Dabela A, Jimenez Y, Supko JG, Hall JE. Pharmacokinetic factors contribute to the inverse relationship between luteinizing hormone and body mass index in polycystic ovarian syndrome. J Clin Endocrinol Metab. 2007 Apr;92(4):1347-52. Epub 2007 Jan 30.
• Joffe H, Gottschall H,Petrillo L, Soares CN, Viguera AC, Hall JE*, Cohen LC* Treatment of premenstrual worsening of depression with adjunctive oral contraceptive pills: a preliminary report. J Clin Psychiatry. 2007 (in press) * contributed equally as senior author
• Pitteloud N, Quinton R, Pearce S, Raivio T, Acierno J, Dwyer A, Plummer L, Hughes V, Seminara S, Cheng YZ, Li WP, Maccoll G, Eliseenkova AV, Olsen SK, Ibrahimi OA, Hayes FJ, Boepple P, Hall JE, Bouloux P, Mohammadi M, Crowley W. Digenic mutations account for variable phenotypes in idiopathic hypogonadotropic hypogonadism. J Clin Invest. 2007 Feb;117(2):457-63. Epub 2007 Jan 18.
• Hall JE. Neuroendocrine changes with reproductive aging in women. Semin Reprod Med. 2007 Sep;25(5):344-51. Review.
• Joffe H, Cohen LS, Suppes T, Hwang CH, Molay F, Adams JM, Sachs GS, Hall JE. Longitudinal Follow-up of Reproductive and Metabolic Features of Valproate-Associated Polycystic Ovarian Syndrome Features: A Preliminary Report. Biol Psychiatry. 2006 Aug 31; [Epub ahead of print] PMID: 16950230
• Lavoie HB, Marsh EE, Hall JE. Absence of apparent circadian rhythms of gonadotropins and free alpha-subunit in postmenopausal women: evidence for distinct regulation relative to other hormonal rhythms. J Biol Rhythms. 2006;21(1):58-67
• Welt CK, Jimenez Y, Sluss PM, Smith PC, Hall JE. Control of estradiol secretion in reproductive ageing. Hum Reprod. 2006;21(8):2189-93.
• Joffe H, Hall JE, Gruber S, Sarmiento IA, Cohen LS, Yurgelun-Todd D, Martin KA. Estrogen therapy selectively enhances prefrontal cognitive processes: a randomized, double-blind, placebo-controlled study with functional magnetic resonance imaging in perimenopausal and recently postmenopausal women. Menopause. 2006;13(3):411-22.
• Pagan YL, Srouji SS, Jimenez Y, Emerson A, Gill S, Hall JE. Inverse relationship between luteinizing hormone and body mass index in polycystic ovarian syndrome: investigation of hypothalamic and pituitary contributions. J Clin Endocrinol Metab. 2006; 91(4):1309-16.
• Welt CK, Falorni A, Taylor AE, Martin KA, Hall JE. Selective theca cell dysfunction in autoimmune oophoritis results in multifollicular development, decreased estradiol and elevated inhibin B levels. J Clin Endocrinol Metab. 2005; 90:3069-3076.
• Hall JE, Sullivan JP, Richardson GS. Brief wake episodes modulate sleep- inhibited LH secretion in the early follicular phase. J Clin Endocrinol Metab. 2005;90:2050-2055.
• Welt CK, Hall JE, Adams JM, Taylor AE. Relationship of estradiol and inhibin to the FSH variability in hypergonadotropic hypogonadism or premature ovarian failure. J Clin Endocrinol Metab. 2005; 90: 826-830.
• Adams JM, Taylor AE, Crowley WF Jr, Hall JE. Polycystic ovarian morphology with regular ovulatory cycles: insights into the pathophysiology of polycystic ovarian syndrome (PCOS). J Clin Endocrinol Metab. 2004;89:4343-4350.
• Hall JE. Neuroendocrine physiology of the early and late menopause. In: Endocrine & Metabolism Clinics of North America. Santoro N and Chervanak J (eds). Philadelphia, PA: Elsevier Publishing;2004. p. 637-659.