Dr.
Sluss' research laboratory has been focusing on the role of a small molecular
weight inhibitor in FSH inhibition of its binding to its receptor, the putative
role of this inhibitor in premature ovarian failure, and the physiology of follistatin
in the regulation of FSH biosynthesis and secretion. In
addition, Dr. Sluss runs the Radioimmunoassay Core of the Reproductive Endocrine
Sciences Center.
Dr. Sluss has determined the presence and charted the course of a small molecular weight inhibitor of FSH binding to its receptor that appears to be produced within the human follicle, caused premature ovarian failure in selected numbers of patients, and is related to anchoring proteins on the cell surface of granulosa cells.This small molecular weight inhibitor competes with the binding of FSH for its receptor inhibition and thereby causes resistance to FSH via this mechanism.
Dr. Sluss is currently determining the hormonal regulation, physiology of this inhibitor across the human menstrual cycle as well as in various disease processes, and its role in other species. Dr. Sluss is a Center Investigator in the Reproductive Endocrine Sciences Center.
Selected Publications:
Barbieri RL, Sluss PM, Powers RD, McShane PM, Vitonis A, Ginsburg E, Cramer DC. Association of body mass index, age, and cigarette smoking with serum testosterone levels in cycling women undergoing in vitro fertilization. Fertil Steril. 2005 Feb;83(2):302-8.
Dighe AS, Moy JM, Hayes FJ, Sluss PM. High-resolution reference ranges for estradiol, luteinizing hormone, and follicle-stimulating hormone in men and women using the AxSYM assay system. Clin Biochem. 2005 Feb;38(2):175-9.
Januzzi JL Jr, Camargo CA, Anwaruddin S, Baggish AL, Chen AA, Krauser DG, Tung R, Cameron R, Nagurney JT, Chae CU, Lloyd-Jones DM, Brown DF, Foran-Melanson S, Sluss PM, Lee-Lewandrowski E, Lewandrowski KB. The N-terminal Pro-BNP investigation of dyspnea in the emergency department (PRIDE) study. Am J Cardiol. 2005 Apr 15;95(8):948-54.
Terry KL, De Vivo I, Titus-Ernstoff L, Sluss PM, Cramer DW. Genetic variation in the progesterone receptor gene and ovarian cancer risk. Am J Epidemiol. 2005 Mar 1;161(5):442-51.
Dighe AS, Hayes FJ, Khosravi J, Bodani U, Sluss PM. Comparison of inhibin A immunoassays: recommendation for adoption of standardized reporting. Clin Chem. 2004 Apr;50(4):767-9.
Dighe AS, Sluss PM. Improved detection of serum estradiol after sample extraction procedure. Clin Chem. 2004 Apr;50(4):764-6.
Klein NA, Houmard BS, Hansen KR, Woodruff TK, Sluss PM, Bremner WJ, Soules MR. Age-related analysis of inhibin A, inhibin B, and activin a relative to the intercycle monotropic follicle-stimulating hormone rise in normal ovulatory women. J Clin Endocrinol Metab. 2004 Jun;89(6):2977-81.
Kratz A, Ferraro M, Sluss PM, Lewandrowski KB. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Laboratory reference values. N Engl J Med. 2004 Oct 7;351(15):1548-63.
Schneyer AL, Wang Q, Sidis Y, Sluss PM. Differential distribution of follistatin isoforms: Application of a new FS315-specific immunoassay. J. Clin Endocrinol Metab 2004; 89:5067-75.
Sluss
PM, Lee-Lewandrowski
E, Flood J, Eichbaum Q, Lewandrowski K. Establishment of a central laboratory
serum tumor marker service on a consolidated immunodiagnostic
platform: development of practice standards, service improvements, and operational
efficiency. Clin Leadersh Manag Rev. 2004 Jan-Feb;18(1):25-31.
Terry KL, Sluss PM, Skates SJ, Mok SC, Ye B, Vitonis AF, Cramer DW. Blood and urine markers for ovarian cancer: a comprehensive review. Dis Markers. 2004;20(2):53-70.
Cramer DW, Sluss PM, Powers RD, McShane P, Ginsburgs ES, Hornstein MD, Vitonis AF, Barbieri RL. Serum prolactin and TSH in an in vitro fertilization population: is there a link between fertilization and thyroid function? J Assist Reprod Genet. 2003 Jun;20(6):210-5.
Houmard BS, Hansen KA, Woodruff TK, Sluss PM, Bremner WJ, Soules MR, Klein NA. Age-related analysis of inhibin A and B relative to the intercycle monotropic FSH rise in normal ovulatory women. Ann Endocrinol (Paris). 2003 Apr;64(2):86. No abstract available.