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Recent Publications of the Reproductive Endocrine Unit

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2008

Boepple PA, Hayes FJ, Dwyer AA, Raivio T, Lee H, Crowley WF Jr, Pitteloud N.
Relative roles of inhibin B and sex steroids in the negative feedback regulation of follicle-stimulating hormone in men across the full spectrum of seminiferous epithelium function. J Clin Endocrinol Metab. 2008 Feb 12; [Epub ahead of print] PMID: 18270253

Hughes VA, Boepple PA, Crowley WF Jr, Seminara SB. Interplay between Dose and Frequency of GnRH Administration in Determining Pituitary Gonadotropin Responsiveness. Neuroendocrinology. 2007 Dec 7; [Epub ahead of print]

Martin KA, Chang RJ, Ehrmann DA, Ibanez L, Lobo RA, Rosenfield RL, Shapiro J, Montori VM, Swiglo BA. Evaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2008 Feb 5; [Epub ahead of print] PMID: 1825279

Pitteloud N, Dwyer AA, Decruz S, Lee H, Boepple PA, Crowley WF Jr, Hayes FJ.
Inhibition of luteinizing hormone secretion by testosterone in men requires aromatization for its pituitary but not its hypothalamic effects: evidence from the tandem study of normal and gonadotropin-releasing hormone-deficient men. J Clin Endocrinol Metab. 2008 Mar;93(3):784-91. Epub 2007 Dec 11. PMID: 18073301

Sluss PM, Hayes FJ, Adams JM, Barnes W, Williams G, Frost S, Ramp J, Pacenti D, Lehotay DC, George S, Ramsay C, Doss RC, Crowley WF Jr. Mass spectrometric and physiological validation of a sensitive, automated, direct immunoassay for serum estradiol using the Architect. Clin Chim Acta. 2008 Feb;388(1-2):99-105. Epub 2007 Nov 26.  PMID: 18023274

Sluss PM, Hall JE, Eichhorn JH, Lewandrowski K. CHECKSAMPLE: Hirsutism and hyperandrogenism. Clinical Chemistry 2008 (in press).

Teles MG, Bianco SD, Brito VN, Trarbach EB, Kuohung W, Xu S, Seminara SB, Mendonca BB, Kaiser UB, Latronico AC. A GPR54-activating mutation in a patient with central precocious puberty. N Engl J Med. 2008 Feb 14;358(7):709-15.
PMID: 18272894

Welt CK. Primary ovarian insufficiency: a more accurate term for premature ovarian failure. Clin Endocrinol (Oxf). 2008 Apr;68(4):499-509. Epub 2007 Oct 29.  PMID: 1797077

Xia Y, Babitt JL, Sidis Y, Chung RT, Lin HY. Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. Blood. 2008 Mar 7; [Epub ahead of print] PMID: 1832681

2007

Lapatto R, Pallais JC, Zhang D, Chan YM, Mahan A, Cerrato F, Le WW, Hoffman GE, Seminara SB. Kiss1 / mice exhibit more variable hypogonadism than gpr54 / mice. Endocrinology. 2007 Oct;148(10):4927-36. Epub 2007 Jun 26. PMID: 17595229

Babitt JL, Huang FW, Xia Y, Sidis Y, Andrews NC, Lin HY. Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. J Clin Invest. 2007 Jul 2;117(7):1933-1939. PMID: 17607365

Cerrato F, Seminara SB. Human genetics of GPR54. Rev Endocr Metab Disord. 2007 Mar;8(1):47-55.  PMID: 17334928

Crowley WF Jr.  Drug development and clinical research in the UK. Lancet. 2007 Jan 20;369(9557):174-5. No abstract available.  PMID: 17240271

Hall JE. Neuroendocrine changes with reproductive aging in women. Semin Reprod Med. 2007;25:344-51

Joffe H, Gottschall H,Petrillo L, Soares CN, Viguera AC, Hall JE*, Cohen LC* Treatment of premenstrual worsening of depression with adjunctive oral contraceptive pills: a preliminary report. J Clin Psychiatry. 2007;68(12):1954-62.* contributed equally as senior author

Mukherjee A, Sidis Y, Mahan A, Raher MJ, Xia Y, Rosen ED, Bloch KD, Thomas MK, Schneyer AL. FSTL3 deletion reveals roles for TGF-beta family ligands in glucose and fat homeostasis in adults. Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1348-53. Epub 2007 Jan 17.  PMID: 17229845

Page-Wilson G, Smith PC, Welt CK. Short-term prolactin administration causes expressible galactorrhea but does not affect bone turnover: pilot data for a new lactation agent. Breastfeed J. 2007 Jul 24;2(1):10 [Epub ahead of print] MID: 17650319

Pitteloud N, Zhang C, Pignatelli D, Li JD, Raivio T, Cole LW, Plummer L, Jacobson-Dickman EE, Mellon PL, Zhou QY, Crowley WF Jr. Loss-of-function mutation in the prokineticin 2 gene causes Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism. Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17447-52. Epub 2007 Oct 24. PMID: 17959774

Raivio T, Falardeau J, Dwyer A, Quinton R., Hayes FJ., Pearce S, Cole L, Crowley W.Jr., Pitteloud N. Reversal of Congenital Idiopathic Hypogonadotropic Hypogonadism After Stopping Treatment. N Engl J Med. 2007 Aug 30;357(9):863-73. PMID: 17761590

Pitteloud N, Quinton R, Pearce S, Raivio T, Acierno J, Dwyer A, Plummer L, Hughes V, Seminara S, Cheng YZ, Li WP, Maccoll G, Eliseenkova AV, Olsen SK, Ibrahimi OA, Hayes FJ, Boepple P, Hall JE, Bouloux P, Mohammadi M, Crowley W.  Digenic mutations account for variable phenotypes in idiopathic hypogonadotropic hypogonadism. J Clin Invest. 2007 Feb;117(2):457-63. Epub 2007 Jan 18.  PMID: 17235395

Ramaswaqmy S, Seminara SB, Pohl CR, Dipietro MJ, Crowley WF Jr, Plant TM. Effect of continuous iv administration of human metastin 45-54 on the neuroendocrine activity of the hypothalamic-pituitary-testicular axis in the adult male rhesus monkey (Macaca mulatta). Endocrinology. 2007 Jul;148(7):3364-70. Epub 2007  PMID: 17412800

Seminara SB. Converging at puberty's hub. Endocrinology. 2007 Nov;148(11):5145-6. No abstract available. PMID: 17940187

Seminara SB.  Kisspeptin in reproduction. Semin Reprod Med. 2007 Sep;25(5):337-43. Review.  PMID: 17710729

*Srouji SS, *Pagan YL, D’Amatao F, Dabela A, Jimenez Y, Supko JG, Hall JE. Pharmacokinetic factors contribute to the inverse relationship between luteinizing hormone and body mass index in polycystic ovarian syndrome. J Clin Endocrinol Metab. 2007 Apr;92(4):1347-52. Epub 2007 Jan 30.  *Contributed equally as first author. PMID: 17264175

Welt CK. Will leptin become the treatment of choice for functional hypothalamic amenorrhea? Nat Clin Pract Endocrinol Metab. 2007 Aug;3(8):556-7. Epub 2007 Jun 26. No abstract available. PMID: 17593916

Wittenberger MD, Hagerman RJ, Sherman SL, McConkie-Rosell A, Welt CK, Rebar RW, Corrigan EC, Simpson JL, Nelson LM. The FMR1 premutation and reproduction.
Fertil Steril. 2007 Mar;87(3):456-65. Epub 2006 Oct 30. Review. PMID: 17074338

Xia Y, Yu PB, Sidis Y, Beppu H, Bloch KD, Schneyer AL, Lin HY. Repulsive guidance molecule (RGMa) alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. 2007 Jun 22;282(25):18129-40. May 1; [Epub 2007 May 1]   PMID: 17472960

Yialamas MA, Dwyer AA, Hanley E, Lee H, Pitteloud N, Hayes FJ. Acute sex steroid withdrawal reduces insulin sensitivity in healthy men with idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2007 Nov;92(11):4254-9. Epub 2007 Aug 28. PMID: 17726076

2006

Babitt JL, Huang FW, Wrighting DM, Xia Y, Sidis Y, Samad TA, Campagna JA, Chung RT, Schneyer AL, Woolf CJ, Andrews NC, Lin HY. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet. 2006 May; 38(5):531-9. Epub 2006 Apr 9.  PMID: 16604073

Bhasin S, Cunningham GR, Hayes FJ, Matsumoto AM, Snyder PJ, Swerdloff RS, Montori VM. Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2006 Jun;91(6):1995-2010. Epub 2006 May 23. Erratum in: J Clin Endocrinol Metab. 2006 Jul;91(7):2688. PMID: 16720669

Cerrato F, Shagoury J, Kralickova M, Dwyer A, Falardeau J, Ozata M, Van Vliet G, Bouloux P, Hall JE, Hayes FH, Pitteloud N, Martin KA, Welt C, Seminara SB. Coding sequence analysis of GNRHR and GPR54 in patients with congenital and adult-onset forms of hypogonadotropic hypogonadism. Eur J Endocrinol. 2006 Nov;155 Suppl 1:S3-S10.  PMID: 17074994

Corssmit EP, Seminara SB, Pitteloud N, Fliers E. Kallmann syndrome in a 47,XXX patient. Am J Med Genet A. 2005 Nov 15;139A(1):52-53.  PMID: 16222664 [No abstract available]

Hall JE. Hypertension: Update 2006. Hypertension. 2006 Sep;48(3):343-346. Epub 2006 Aug 7. No abstract available. PMID: 16894054

Joffe H, Cohen LS, Suppes T, Hwang CH, Molay F, Adams JM, Sachs GS, Hall JE. Longitudinal Follow-up of Reproductive and Metabolic Features of Valproate-Associated Polycystic Ovarian Syndrome Features: A Preliminary Report. Biol Psychiatry. 2006 Aug 31; [Epub ahead of print]  PMID: 16950230

Joffe H, Hall JE, Gruber S, Sarmiento IA, Cohen LS, Yurgelun-Todd D, Martin KA. Estrogen therapy selectively enhances prefrontal cognitive processes: a randomized, double-blind, placebo-controlled study with functional magnetic resonance imaging in perimenopausal and recently postmenopausal women. Menopause. 2006 May-Jun;13(3):411-22.  PMID: 16735938

Kumar PA, Pitteloud N (first Co-author), Andrews PA, Dwyer AA, Hayes F, Crowley WF, Dym M. Testis morphology in patients with idiopathic hypogonadotropic hypogonadism. Hum Reprod. 2006; 21: 1033-40

Lavoie HB, Marsh EE, Hall JE. Absence of apparent circadian rhythms of gonadotropins and free alpha-subunit in postmenopausal women: evidence for distinct regulation relative to other hormonal rhythms. J Biol Rhythms 2006 Feb;21(1):58-67. PMID: 16461985.

Murphy MK, Hall JE, Adams JM, Lee H, Welt CK. Polycystic Ovarian Morphology in Normal Women Does Not Predict the Development of Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 2006 Oct;91(10):3878-84. Epub 2006 Aug 1. PMID: 16882750

Pagan YL, Srouji SS, Jimenez Y, Emerson A, Gill S, Hall JE. Inverse relationship between luteinizing hormone and body mass index in polycystic ovarian syndrome: investigation of hypothalamic and pituitary contributions. J Clin Endocrinol Metab. 2006 Apr;91(4):1309-16. Epub 2006 Jan 24.  PMID: 16434454

Page-Wilson G, Smith PC, Welt CK. Prolactin Suppresses GnRH but Not TSH Secretion. Hormone Research 2006;65:31-38 [Epub ahead of print]
PMID: 16357488.

Pallais JC, Bo-Abbas Y, Pitteloud N, Crowley WF Jr, Seminara SB. Neuroendocrine, gonadal, placental, and obstetric phenotypes in patients with IHH and mutations in the G-protein coupled receptor, GPR54. Mol Cell Endocrinol. 2006 Jul 25;254-255:70-7. Epub 2006 Jun 6.  PMID: 16757106

Pitteloud N, Acierno J.S, jr., Meysing A., Eliseenkova A.V., Ma J., Ibrahimi O.A., Metzger D., Hayes F.J., Dwyer A.A., Hughes V.A., Yialamas, M., Hall J.E., Grant E., Mohammadi M., Crowley W.F.Jr. Mutations in FGFR1 cause both Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism. PNAS, 2006;103:6281-6.

Pitteloud N, Mootha VK, Dwyer AA, Hardin M, Lee H, Eriksson KF, Tripathy D, Yialamas M, Groop L, Elahi D, Hayes FJ. Relationship between testosterone levels, insulin sensitivity, and mitochondrial function in men. Diabetes Care. 2005 Jul;28(7):1636-42. PMID: 15983313

Pitteloud N, Meysing A., Quinton R., Acierno J.S., jr. , Dwyer A.A., Plummer L., Fliers E., Boepple P., Hayes F, Seminara S, Hughes V.A., Bouloux P., Mohammadi M., Crowley W.F. Jr. Mutations in FGFR1 cause Kallmann syndrome with a wide spectrum of reproductive phenotype. Mol. Cell. Endo. 2006, 60, 254-255

Seminara SB, Dipietro MJ, Ramaswamy S, Crowley WF Jr, Plant TM. Continuous human metastin 45-54 infusion desensitizes G protein-coupled receptor 54-induced gonadotropin-releasing hormone release monitored indirectly in the juvenile male Rhesus monkey (Macaca mulatta): a finding with therapeutic implications. Endocrinology. 2006 May;147(5):2122-6. Epub 2006 Feb 9.  PMID: 16469799

Seminara, SB. Mechanisms of Disease: the first kiss-a crucial role for kisspeptin-1 and its receptor, G-protein-coupled receptor 54, in puberty and reproduction. Nat Clin Pract Endocrinol Metab. 2006 Jun;2(6):328-34.  PMID: 16932310

Sidis Y, Mukherjee A, Keutmann H, Delbaere A, Sadatsuki M, Schneyer A. Biological activity of follistatin isoforms and follistatin-like-3 is dependent on differential cell surface binding and specificity for activin, myostatin, and bone morphogenetic proteins. Endocrinology. 2006 Jul;147(7):3586-97. Epub 2006 Apr 20.  PMID: 16627

Welt CK, Jimenez Y, Sluss PM, Smith PC, Hall JE. Control of estradiol secretion in reproductive ageing. Hum Reprod. 2006 Aug;21(8):2189-93. Epub 2006 May 9.  PMID: 16684841

Welt CK, Arason G, Gudmundsson JA, Adams J, Palsdottir H, Gudlaugsdottir G, Ingadottir G, Crowley WF. Defining Constant Versus Variable Phenotypic Features of Women with Polycystic Ovary Syndrome using Different Ethnic Groups and Populations.
J Clin Endocrinol Metab. 2006 Aug 29; [Epub ahead of print]  PMID: 16940441

Welt CK, Gudmundsson JA, Arason G, Adams J, Palsdottir H, Gudlaugsdottir G, Ingadottir G, Crowley WF. Characterizing discrete subsets of polycystic ovary syndrome as defined by the Rotterdam criteria: the impact of weight on phenotype and metabolic features. J Clin Endocrinol Metab. 2006 Dec;91(12):4842-8. Epub 2006 Sep 26.
PMID: 17003085

2005

Babitt JL, Zhang Y, Samad TA, Xia Y, tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY. Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor. J Biol Chem. 2005 Aug 19;280(33):29820-7. Epub 2005 Jun 23.  PMID: 15975920 [PubMed - indexed for MEDLINE]

Barbieri RL, Sluss PM, Powers RD, McShane PM, Vitonis A, Ginsburg E, Cramer DC. Association of body mass index, age, and cigarette smoking with serum testosterone levels in cycling women undergoing in vitro fertilization. Fertil Steril. 2005 Feb;83(2):302-8.

Dighe AS, Moy JM, Hayes FJ, Sluss PM. High-resolution reference ranges for estradiol, luteinizing hormone, and follicle-stimulating hormone in men and women using the AxSYM assay system. Clin Biochem. 2005 Feb;38(2):175-9.

Ellison ME, Hotamisligil S, Lee H, Rich-Edwards JW, Pang SC, Hall JE. Psychosocial risks associated with fertility treatment-related multiple births. Fertil Steril. 2005;83:1422-1428.

Hall JE, Sullivan JP, Richardson GS. Brief wake episodes modulate sleep- inhibited LH secretion in the early follicular phase. J Clin Endocrinol Metab. 2005;90:2050-2055.

Januzzi JL Jr, Camargo CA, Anwaruddin S, Baggish AL, Chen AA, Krauser DG, Tung R, Cameron R, Nagurney JT, Chae CU, Lloyd-Jones DM, Brown DF, Foran-Melanson S, Sluss PM, Lee-Lewandrowski E, Lewandrowski KB. The N-terminal Pro-BNP investigation of dyspnea in the emergency department (PRIDE) study. Am J Cardiol. 2005 Apr 15;95(8):948-54.

Pitteloud N, Hardin M, Dwyer AA, Valassi E, Yialamas M, Elahi D, Hayes FJ. Increasing insulin resistance is associated with a decrease in leydig cell testosterone secretion in men. J Clin Endocrinol Metab. 2005 May;90(5):2636-41. Epub 2005 Feb 15.

Pitteloud N, Acierno JS Jr, Meysing AU, Dwyer AA, Hayes FJ, Crowley WF Jr. Reversible kallmann syndrome, delayed puberty, and isolated anosmia occurring in a single family with a mutation in the fibroblast growth factor receptor 1 gene. J Clin Endocrinol Metab. 2005 Mar;90(3):1317-22. Epub 2004 Dec 21.

Potischman N, Troisi R, Thadhani R, Hooever RN, Dodd K, Davis WW, Sluss PM, Hsieh CC, Ballar-Barbash R. Pregnancy hormone concentrations across ethnic groups: implications for later cancer risk. Cancer Epidemiol Biomarkers Prev. 2005 Jun;14(6):1514-20. PMID: 15941965

Saito S, Sidis Y, Mukherjee A, Xia Y, Schneyer A. Differential biosynthesis and intracellular transport of follistatin isoforms and follistatin-like-3. Endocrinology. 2005 Dec;146(12):5052-62. Epub 2005 Sep 8.  PMID: 16150905 [PubMed - in process]

Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ. DRAGON, a bone morphogenetic protein co-receptor. J Biol Chem. 2005 Apr 8;280(14):14122-9. Epub 2005 Jan 25

Seminara SB, Kaiser UB. New gatekeepers of reproduction: GPR54 and its cognate ligand, KiSS-1. Endocrinology. 2005 Apr;146(4):1686-8.

Seminara SB. We all remember our first kiss: kisspeptin and the male gonadal axis.
J Clin Endocrinol Metab. 2005 Dec;90(12):6738-40. No abstract available.
PMID: 16330809

Seminara SB. Metastin and its G protein-coupled receptor, GPR54: Critical pathway modulating GnRH secretion. Front Neuroendocrinol. 2005 Oct-Dec;26(3-4):131-8. Epub 2005 Nov 23. PMID: 16309735

Shahab M, Mastronardi C, Seminara SB, Crowley WF, Ojeda SR, Plant TM.
Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates.
Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2129-34. Epub 2005 Jan 31.

Sidis Y, Schneyer AL, Keutmann HT. Heparin and activin-binding determinants in follistatin and FSTL3. Endocrinology. 2005 Jan;146(1):130-6. Epub 2004 Oct 7.

Terry KL, De Vivo I, Titus-Ernstoff L, Sluss PM, Cramer DW. Genetic variation in the progesterone receptor gene and ovarian cancer risk. Am J Epidemiol. 2005 Mar 1;161(5):442-51.

Welt CK, Hall JE, Adams JM, Taylor AE. Relationship of estradiol and inhibin to the FSH variability in hypergonadotropic hypogonadism or premature ovarian failure. J Clin Endocrinol Metab. 2005; 90: 826-830.

Welt CK, Falorni A, Taylor AE, Martin KA, Hall JE. Selective theca cell dysfunction in autoimmune oophoritis results in multifollicular development, decreased estradiol and elevated inhibin B levels. J Clin Endocrinol Metab. 2005; 90:3069-3076.

Welt CK, Taylor AE, Fox J, Messerlian GM, Adams JM, Schneyer AL. Follicular arrest in polycystic ovary syndrome is associated with deficient inhibin A and B biosynthesis..J Clin Endocrinol Metab. 2005 Oct;90(10):5582-7. Epub 2005 Jul 19.  PMID: 16030174 [PubMed - indexed for MEDLINE]

Xia Y, Sidis Y, Mukherjee A, Samad TA, Brenner G, Woolf CJ, Lin HY, Schneyer A. Localization and action of Dragon (repulsive guidance molecule b), a novel bone morphogenetic protein coreceptor, throughout the reproductive axis. Endocrinology. 2005 Aug;146(8):3614-21. Epub 2005 May 12. PMID: 15890774 [PubMed - indexed for MEDLINE

2004

Adams JM, Taylor AE, Crowley WF Jr, and Hall JE. Polycystic ovarian morphology with regular ovulatory cycles: Insights into the pathophysiology of polycystic ovarian syndrome. J. Clin. Endo. Metab. 2004 ;89(9):4343-4350.

Crowley WF Jr, Sherwood L, Salber P, Scheinberg D, Slavkin H, Tilson H, Reece EA, Catanese V, Johnson SB, Dobs A, Genel M, Korn A, Reame N, Bonow R, Grebb J, Rimoin D. Clinical research in the United States at a crossroads: proposal for a novel public-private partnership to establish a national clinical research enterprise. JAMA. 2004 Mar 3;291(9):1120-6.

Del Re E, Babitt JL, Pirani A, Schneyer AL, Lin HY. In the absence of type III receptor, the TGF-beta type II-B receptor requires the type I receptor to bind TGF-beta 2. J Biol Chem. 2004 May 21;279(21):22765-72. Epub 2004 Mar 02.

Del Re E, Sidis Y, Fabrizio DA, Lin HY, Schneyer A. Reconstitution and analysis of soluble inhibin and activin recetor complexes in a cell-free system. J. Biol. Chem 2004; 279:53126-35..

Dighe AS, Hayes FJ, Khosravi J, Bodani U, Sluss PM. Comparison of inhibin A immunoassays: recommendation for adoption of standardized reporting. Clin Chem. 2004 Apr;50(4):767-9. No abstract available.

Dighe AS, Sluss PM. Improved detection of serum estradiol after sample extraction procedure. Clin Chem. 2004 Apr;50(4):764-6.

Gottsch ML, Cunningham MJ, Smith JT, Popa SM, Acohido BV, Crowley WF, Seminara S, Clifton DK, Steiner RA. A role for kisspeptins in the regulation of gonadotropin secretion in the mouse. 2004 Endocrinol. 145(9): 4073-4077.

Hall JE. Neuroendocrine physiology of the early and late menopause. Endocrinol Metab Clin North Am. 2004 Dec;33(4):637-59.

Hall JE. Infertility and fertility control. In: Harrison's Principles of Internal Medicine. Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson LF (eds). New York, NY: McGraw-Hill Companies, Inc;2004. p. 279-283.

Hall JE. Neuroendocrine control of the menstrual cycle. In: Yen and Jaffe's Reproductive Endocrinology. J Strauss, R Barbieri (eds). Philadelphia, PA: Elsevier Publishing;2004. p. 195-211.

Keutmann HT, Schneyer AL, Sidis Y. The role of follistatin domains in follistatin biological action. Mol Endocrinol. 2004 Jan;18(1):228-40. Epub 2003 Oct 16.

Klein NA, Houmard BS, Hansen KR, Woodruff TK, Sluss PM, Bremner WJ, Soules MR. Age-related analysis of inhibin A, inhibin B, and activin a relative to the intercycle monotropic follicle-stimulating hormone rise in normal ovulatory women. J Clin Endocrinol Metab. 2004 Jun;89(6):2977-81.

Kratz A, Ferraro M, Sluss PM, Lewandrowski KB. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Laboratory reference values. N Engl J Med. 2004 Oct 7;351(15):1548-63.

Margolin DH, Ibrahim A, Sims KS, Milunsky JM, Milunsky A, Seminara SB, Chan J, Hedley-Whyte ET. Hypogonadism-ataxia-dementia syndrome with neuronal intranuclear inclusions. 2004 J Neurol Neurosurg Psych. In press.

Meysing AU, Kanasaki H, Bedecarrats GY, Acierno JS Jr, Conn PM, Martin KA, Seminara SB, Hall JE, Crowley WF Jr, Kaiser UB. GNRHR mutations in a woman with idiopathic hypogonadotropic hypogonadism highlight the differential sensitivity of luteinizing hormone and follicle-stimulating hormone to gonadotropin-releasing hormone. J Clin Endocrinol Metab. 2004 Jul;89(7):3189-98.

Miura K, Acierno JS Jr, Seminara SB. Characterization of the human nasal embryonic LHRH factor gene, NELF, and a mutation screening among 65 patients with idiopathic hypogonadotropic hypogonadism (IHH). J Hum Genet. 2004 Apr 15 [Epub ahead of print]

Pitteloud N, Villegas J, Dwyer AA, Crowley WF Jr, McPhaul MJ, Hayes FJ. Acute stress masking the biochemical phenotype of partial androgen insensitivity syndrome in a patient with a novel mutation in the androgen receptor. J Clin Endocrinol Metab. 2004 Mar;89(3):1053-8.

Schneyer A, Sidis Y, Xia Y, Saito S, del Re E, Lin HY, Keutmann H. Differential actions of follistatin and follistatin-like 3. Mol. Cell. Endo. 2004 Oct;225(1-2):25-28.

Schneyer AL, Wang Q, Sidis Y, Sluss PM. Differential distribution of follistatin isoforms: Application of a new FS315-specific immunoassay. J. Clin Endocrinol Metab 2004; 89:5067-75.

Sidis Y, Schneyer AL, Keutmann HT. Heparin and activin-binding determinants in follistatin and FSTL3. Endocrinology 2004; In Press.

Sluss PM, Lee-Lewandrowski E, Flood J, Eichbaum Q, Lewandrowski K. Establishment of a central laboratory serum tumor marker service on a consolidated immunodiagnostic platform: development of practice standards, service improvements, and operational efficiency. Clin Leadersh Manag Rev. 2004 Jan-Feb;18(1):25-31.

Terry KL, Sluss PM, Skates SJ, Mok SC, Ye B, Vitonis AF, Cramer DW. Blood and urine markers for ovarian cancer: a comprehensive review. Dis Markers. 2004;20(2):53-70.

Turgeon JL, McDonnell DP, Martin KA, Wise PM. Hormone therapy: physiological complexity belies therapeutic simplicity. Science 2004; 304 (5675): 1269-73.

Welt CK, Smith PC, Taylor AE. Evidence of early ovarian aging in fragile X premutation carriers. J Clin Endocrinol Metab. 2004 Sep;89(9):4569-74.

Welt CK, Chan JL, Bullen J, Murphy R, Smith P, DePaoli AM, Karalis A, Mantzoros CS. Recombinant human leptin in women with hypothalamic amenorrhea. N Engl J Med. 2004 Sep 2;351(10):959-62.

Welt CK. Regulation and function of inhibins in the normal menstrual cycle. Semin Reprod Med. 2004 Aug;22(3):187-93.

Xia Y, Sidis Y, Schneyer A. Overexpression of follistatin-like 3 in gonads causes defects in gonadal development and function in transgenic mice. Mol Endocrinol. 2004 Apr;18(4):979-94. Epub 2004 Jan 22.

Pitteloud N, Acierno JS, Meysing AU, Dwyer AA, Hayes FJ, Crowley WF. Reversible Kallmann Syndrome, delayed puberty, and isolated anosmia occurring in a single family with a mutation in the FGFR1 gene. J Clin Endocrinol Metab Dec 2004.

2003

Acierno JS jr, Shagoury JK, Bo-Abbas Y, Crowley WF Jr, Seminara SB.
(2003) A locus for autosomal recessive idiopathic hypogonadotropic
hypogonadism on chromosome 19p13.3
. J Clin Endocrinol Metab. 2003;88:2947-2950.

Bedecarrats GY, Linher KD, Janovick JA, Beranova M, Kada F, Seminara SB, Michael Conn P, Kaiser UB. Four naturally occurring mutations in the human GnRH receptor affect ligand binding and receptor function. Mol Cell Endocrinol. 2003 Jul 31;205(1-2):51-64.

Bo-Abbas Y, Acierno JS Jr., Shagoury JK, Crowley WF Jr., Seminara SB.
(2003) Existence of an autosomal recessive locus for idiopathic
hypogonadotropic hypogonadism independent of GnRH and the GnRH receptor
genes
. J Clin Endocrinol Metab. 2003; 88:2730-2737.

Cramer DW, Sluss PM, Powers RD, McShane P, Ginsburgs ES, Hornstein MD, Vitonis AF, Barbieri RL. Serum prolactin and TSH in an in vitro fertilization population: is there a link between fertilization and thyroid function? J Assist Reprod Genet. 2003 Jun;20(6):210-5.

Crowley WF. Translation of basic research into useful treatments: how often does it occur? Am J Med 2003; 114(6):503-505.

Ellison MA and Hall JE. Social stigma and compounded losses: quality-of-life issues for multiple-birth families. Fertility and Sterility 2003:80:405-414.

Houmard BS, Hansen KA, Woodruff TK, Sluss PM, Bremner WJ, Soules MR, Klein NA. Age-related analysis of inhibin A and B relative to the intercycle monotropic FSH rise in normal ovulatory women. Ann Endocrinol (Paris). 2003 Apr;64(2):86. No abstract available.

Jain T, Klein NA, Lee DM, Sluss PM, Soules MR. Endocrine assessment of relative reproductive age in normal eumenorrheic younger and older women across multiple cycles. Am J Obstet Gynecol. 2003 Oct;189(4):1080-4.

Joffe H, Hall JE, Cohen LS, Taylor AE, Baldessarini RJ. A putative relationship between valproic acid and polycystic ovarian syndrome: implications for treatment of women with seizure and bipolar disorders. Harv Rev Psychiatry. 2003 Mar-Apr,11(2):99-108. Review. No abstract available.

Kratz A, Lewandrowski KB, Siegel AJ, Sluss PM, Chun KY, Flood JG, Lee-Lewandrowski E. Effect of marathon running on total and free serum prostate-specific antigen concentrations. Arch Pathol Lab Med. 2003 Mar;127(3):345-8.

Leupen SM, Tobet SA, Crowley WF Jr, Kaila K. Heterogeneous expression of the potassium-chloride cotransporter KCC2 in gonadotropin-releasing hormone neurons of the adult mouse. Endocrinology. 2003 Jul;144(7):3031-6.

Rexrode KM, Manson JE, Lee IM, Ridker PM, Sluss PM, Cook NR, Buring JE. Sex hormone levels and risk of cardiovascular events in postmenopausal women. Circulation. 2003 Oct 7;108(14):1688-93.

Schneyer A, Schoen A, Quigg A, Sidis Y. Differential binding and neutralization of activins A and B by follistatin and follistatin like-3 (FSTL-3/FSRP/FLRG).
Endocrinology. 2003 May;144(5):1671-4.

Seminara SB, Messager S, Chatzidaki EE, Thresher RR, Acierno JS Jr, Shagoury JK, Bo-Abbas Y, Kuohung W, Schwinof KM, Hendrick AG, Zahn D, Dixon J, Kaiser UB, Slaugenhaupt SA, Gusella JF, O'Rahilly S, Carlton MB, Crowley WF Jr, Aparicio SA, Colledge WH. The GPR54 gene as a regulator of puberty. N Engl J Med. 2003 Oct 23;349(17):1614-27.

Sung NS, Crowley WF, Jr., Genel M et al. Central challenges facing the national clinical research enterprise. JAMA 2003; 289(10):1278-1287.

Welt CK, Pagan YL, Smith PC, Rado KB, Hall JE. Control of follicle-stimulating hormone by estradiol and the inhibins: Critical role of estradiol at the hypothalamus during the luteal-follicular transition. J Clin Endocrinol Metab 2003; 88(4):1766-1771.

Welt CK, Schneyer AL, Heist K, Mantzoros CS. Leptin and soluble leptin receptor in follicular fluid. J Assist Reprod Genet. 2003 Dec;20(12):495-501.

Yialamas MA, Hayes FJ. Androgens and the aging male and female. Best Pract Res Clin Endocrinol Metab. 2003 Jun;17(2):223-36. Review.

2002

Gill S, Sharpless JL, Rado K, Hall JE. Evidence that GnRH decreases with gonadal steroid feedback but increases with age in postmenopausal women. J Clin Endocrinol Metab 2002; 87(5):2290-2296.

Gill S, Lavoie HB, Bo-Abbas Y, Hall JE. Negative feedback effects of gonadal steroids are preserved with aging in postmenopausal women. J Clin Endocrinol Metab 2002; 87(5):2297-2302.

Gyurko R, Leupen SM, and Huang PL. Deletion of exon 6 of the neuronal nitric oxide synthase gene results in hypogonadism and infertility in Mice. Endocrinology 2002; 143(7):2767-74.

Hayes FJ, Pitteloud N, DeCruz S, Crowley WF Jr, Boepple PA. Importance of inhibin B in the regulation of FSH secretion in the human male. J Clin Endocrinol Metab. 2001;86: 5541-5546.

Joffe H, Hall JE, Soares CN et al. Vasomotor symptoms are associated with depression in perimenopausal women seeking primary care. Menopause 2002; 9(6):392-398.

Klein NA, Harper AJ, Houmard BS, Sluss PM, Soules MR. Is the short follicular phase in older women secondary to advanced or accelerated dominant follicle development? J Clin Endocrinol Metab 2002; 87(12):5746-5750.

Layman LC, Porto AL, Xie J et al. FSH beta gene mutations in a female with partial breast development and a male sibling with normal puberty and azoospermia. J Clin Endocrinol Metab 2002; 87(8):3702-3707.

McNagny SE, Wenger NK, Hilmy N, Banarer S, Barton M, Dubey RK, Davis SR, Manson JE, Martin KA. Postmenopausal hormone-replacement therapy. N Engl J Med. 2002 Jan 3;346(1):63-65.

Pitteloud N, Hayes FJ, Boepple PA, DeCruz S, Seminara SB, MacLaughlin DT, Crowley WF, Jr. The role of prior pubertal development, biochemical markers of testicular maturation, and genetics in elucidating the phenotypic heterogeneity of idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2002;87:152-160.

Pitteloud N, Hayes FJ, Dwyer A, Boepple PA, Lee H, Crowley WF, Jr. Predictors of outcome of long-term GnRH therapy in men with idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab 2002; 87(9):4128-4136.

Schneyer A, Welt C. Reproductive endocrinology of inhibin, activin, and follistatin. Endocrinology Rounds. 2002;1:1-6.

Seminara SB, Crowley WF, Jr. Genetic approaches to unraveling reproductive disorders: examples of bedside to bench research in the genomic era. Endocr Rev 2002; 23(3):382-392.

Seminara SB, Acierno JS, Jr., Abdulwahid NA, Crowley WF, Jr., Margolin DH. Hypogonadotropic hypogonadism and cerebellar ataxia: detailed phenotypic characterization of a large, extended kindred. J Clin Endocrinol Metab 2002; 87(4):1607-1612.

Sidis Y, Tortoriello DV, Holmes WE, Pan Y, Keutmann HT, Schneyer AL. Follistatin-related protein and follistatin differentially neutralize endogenous vs. exogenous activin. Endocrinology 2002; 143(5):1613-1624.

Taylor AE, Stubbs C, Singer DE, Curhan G, Crowley WF, Jr. An instrument for determining the amount of NIH support for clinical investigations at one academic health center. Acad Med 2002; 77(8):824-830.

Welt CK, Taylor AE, Martin KA, Hall JE. Serum inhibin B in polycystic ovary syndrome: regulation by insulin and luteinizing hormone. J Clin Endocrinol Metab 2002; 87(12):5559-5565.

Welt C, Sidis Y, Keutmann H, Schneyer A. Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millennium. Exp Biol Med (Maywood ) 2002; 227(9):724-752.

Welt CK. The Physiology and pathophysiology of inhibin, activin and follistatin in female reproduction. Current Opin Obstet Gynecol. 2002;14:317-323.

 

 

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