CIID Laboratories

• Donald Bloch MD
• Joseph El-Khoury, MD
• Robert Gerszten, MD
• Nir Hacohen, MD, PhD
• Steven Krane, MD
• Andrew Luster, MD, PhD
• Benjamin Medoff, MD
• Thorsten Mempel, MD, PhD
• Cathryn Nagler, PhD
• Allen Steere, MD
• Andrew Tager, MD

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Andrew Luster, MD, PhD

Chief, Division of Rheumatology, Allergy and Immunology
Director, Center for Immunology and Inflammatory Diseases
Professor of Medicine, Harvard Medical School
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Dr. Luster’s laboratory studies the basic biology and pathobiology of chemokines (chemotactic cytokines) and lipid chemoattractants. Chemokines are the largest family of cytokines and control the movement of leukocytes in development, homeostasis, and response to infection and inflammation by binding to specific G protein-coupled seven transmembrane cell surface receptors (GPCRs) on leukocytes. Our research focuses on understanding the role of chemokines and lipid chemoattractant receptors in controlling the trafficking of leukocytes in vivo. His laboratory uses gene-targeted and transgenic overexpressing mouse strains and inhibitory monoclonal antibodies to study the role of individual chemokines and chemoattractant receptors in mouse models of disease.

The laboratory also studies the regulation of chemokine production in vivo in both humans and mice since this is a critical determinant of their role in a given biological response. We believe that a greater understanding of the chemokine superfamily will lead to novel therapies aimed at inhibiting a dysregulated host response in autoimmune and allergic conditions as well as augmenting the host response to tumor cells, infectious agents and vaccines. The laboratory also studies how the innate immune system controls the adaptive immune system through collaborative interactions between Toll-like receptors (TLRs) and scavenger receptors.

Publications

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Lab Members

Junior Faculty

• Shannon Bromley, PhD
• Gabriele Campanella, PhD
• Richard Colvin, MD, PhD
• Sabina Islam, MD
• Terry Means, PhD
• Zamaneh Mikhak, MD

Postdoctoral Fellows

• Roshi Afshar, PhD
• Richard Chou, MD, PhD
• Yung Chyung, MD
• Shaza Fadel, PhD
• Robert Friday, MD, PhD
• Joanna Groom, PhD
• Nancy Kim, MD
• Ed Seung, PhD

Technicians

• Tabitha Abrazinski
• Uwanda Coleman
• Ali Farsidjani
• Alison Mahan

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