Generic Name:

Propofol

Trade Name:

Diprivan ®

Action:

General Anesthetic and sedation in patients mechanical ventilated

Indications:

For short term sedation during mechanical ventilation

Administration Guidelines:

Usual dosage Range and Route:

Starting Dose : 25 - 75 mg/hr

Maintenance Dose : Titrate by 25 mg increments every 15 minutes until desired response is achieved; usual max dose is 300 mg. Morbidly obese patients may require higher doses; contact your floor pharmacist with questions.

Bolus Dose: 10-50mg

Standard Concentrations:

Single use ampules/vials 200mg/20ml in fat emulsion (do not dilute)

Single use infusion bottles 10mg/ml-1000mg/ 100ml infusion bottle in fat emulsion (do not dilute)

EW Standard

Single use infusion bottles 10mg/ml-1000mg/ 100ml infusion bottle in fat emulsion (do not dilute)

Special Considerations:

Soy and egg allergy

Sulfite Warnings
Baxter PPI propofol injectable emulsion contains sodium metabisulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in non-asthmatic people.

Benzyl Alcohol Warning

Bedford Labortatories propofol injectable emulsion contains benzyl alcohol (1mg/ml). However, propofol injectable emulsion can still support the growth of microorganisms and strict aseptic technique must still be adhered to. Benzyl alcohol toxicity is characterized by central nervous system depression and metabolic acidosis. Bedford Labortatories propofol injectable emulsion should not be used for periods longer than 24 hours. Particular caution should be taken for neonates and low-birth weight neonates.

- Propofol vials & ampules are for single use only .

- Consult nutritional support for patients on TPN. Propofol is diluted in 10% fat emulsion.

- Patient must be on mechanical ventilation

- Propofol should not be administered in the same IV line as other medications

- Propofol should be infused via a large peripheral vessel (antecubital fossa or greater) to avoid extravasation.

- Monitor for signs and symptoms of drug withdrawal from previous sedative.

- A label should be affixed to the syringe or infusion bottle and must include date and time prepared/spiked.

- For Ampules or vials : Wipe neck of ampule with alcohol swab prior to drawing up drug. Drug must be withdrawn from the ampule or vial into a syringe immediately after opening, with ampules, use a 5 micron filter needle. Syringes and tubing must be changed every six hours and unused drug discarded.

- For Infusion Bottle : Wipe port of infusion bottle with alcohol swab prior to spiking bottle. Infusion bottles are restricted to use in patients requiring an infusion rate >100mg/hour. Infusion bottles and tubing must be changed every 12 hours and unused drug discarded.

-During Propofol infusions, the delivery system should not be manipulated or violated in any way.

-At end of infusion, flush IV line to remove any residual Propofol.

Precautions and Side Effects

- Hypotension

- Headache, Dizziness

- Nausea, Vomiting

- Rash

- Pain at the site of injection

- Discard any unused portion of drug six hours after ampules have been opened.

- Use with caution in patients with documented egg allergy

- Ileus

- Rapid IVP doses are associated with histamine release