Generic Name:

Naloxone

Trade Name:

Narcan

Action:

Opiate Antagonist

Indications:

Reversal of respiratory depression induced by opiates

Administration Guidelines:

Usual Dosage Range and Route:

0.4 - 2 mg IVP AT 2 to 3 minutes intervals as titrated to patient response for known narcotic overdose up to a maximum of 10 mg

Standard Concentration: *

MICROINFUSION: 20mg/50ml (0.4mg/ml)

EW Standard

20mg/ 50mL(0.4mg/ml)

Special Considerations:

*Naloxone infusions should be reserved for those patients who have a documented narcotic overdose of a long acting opiate and have responded to higher doses of intermittent IV boluses. Maintenance rates are 0.5 to 1.2 mg / hour. For further information, please contact the Pharmacy.

*Naloxone infusions may be used for side effects associated with epidural administration of narcotics. Consult the Pain Service for details.

-For the management of an unconscious victim, naloxone 2 mg can be used in conjunction with thiamine 100 mg ivp and dextrose 25 g ivp.

Precautions and Side Effects:

- Severe withdrawal symptoms

- Hypertension

- Tachycardia

- Nausea, vomiting