Muromonab

Generic Name:	Muromonab CD-3, OKT 3
Trade Name:	Orthoclone
Action:	Monoclonal antibody which inhibits cell mediated immune responses
Indications:	Control of rejection following organ transplantation
Administration Guidelines:
Usual Dose and Route	First and second dose must be given by a physician DOSE: 5 - 10 mg IVP OVER 1 MINUTE DAILY FOR 10 TO 14 DAYS CAUTION: DRUG MUST BE ADMINISTERED UNDILUTED - Administer through filter (0.22 micron low-protein binding) supplied by pharmacy. - Steroid pulse therapy should be given at 12 and 1 hour interval prior to okt-3 administration - Antihistamines and acetaminophen are given 30 minutes prior to first dose to ameliorate adverse reactions.
Special Considerations:	- Monitor patient closely after first and second dose. vital signs must be measured every 15 minutes for 2 hours, then every 30 minutes for 2 hours or until stable. If steroid pulse therapy has been given in the previous 12 hours, steroids may be omitted prior to first dose of okt-3.
Precautions and Side Effects:	- Anaphylaxis, including flushing, acute respiratory distress, and tachycardia - Elevated temperature, rigors - Hypertension, pulmonary edema, fluid retention - Nausea, vomiting, diarrhea - Headache, paresthesia, hyperesthesia, tremors, confusion, seizures, malaise - Arthralgias