MASSACHUSETTS GENERAL HOSPITAL
Department of Pharmacy
Department of Nursing
Critical Care
| Generic Name: | Metoclopramide |
| Trade Name: | Reglan |
| Indications: | Diabetic gastrostasis Post surgical gastrostasis Gastro esophageal reflux Chemotherapy induced nausea and vomiting |
| Actions: | Dopamine receptor antagonist Accelerates gastric emptying time |
| Administration Guidelines: | |
| Usual Dose and Route | Primary gut dysfunction: 10 mg IV
every 6 to 8 hours Chemotherapy induced n/v: 2 mg/kg 30 minutes prior to chemotherapy and 1 mg/kg at 2 - 3 hour intervals post chemotherapy |
| Standard Concentration: |
10mg / 10ml 40mg/40ml 300mg / 60ml |
| Suggested Maximum Dose: | 5 mg / kg |
| Special Considerations: | - Dosage adjustments may be required in:
- Cumulative effect may be observed, dosage adjustment may be required - Moderate to high doses of metoclopramide may be combined with diphenhydramine to avoid dystonic and extrapyramidal side effects |
| Precautions and Side Effects: | - Extrapyramidal symptoms such as
hyperreflexia, parkinson-like symptoms, motor restlessness - Insomnia, agitation, depression, confusion, drowsiness, lethargy - Hypotension - Tachycardia, angina - Respiratory depression - Malignant neuroleptic syndrome |
revised 09/03