MASSACHUSETTS GENERAL HOSPITAL

Department of Pharmacy

Department of Nursing

Critical Care

Generic Name:

Mannitol

Trade Name:

 

Action:

Osmotic Diuretic

Indications:

Osmotic DiuresisContrast
Induced Renal Failure
Increased Intracranial Pressure

Administration Guidelines:

Usual Dosage Range and Route:

12.5 - 25 g IVP, may be repeated every 4 - 6 hours

Standard Concentrations:

12.5 gm / 50 ml (25%)(250mg / ml)

100gm / 500ml ( 20%)(200 mg / ml) 
(premixed)

EW Standard

100gm / 500ml ( 20%)(200 mg / ml) 
(premixed)

Special Considerations:

- Monitor serum & urine electrolytes, serum osmolality

- IV infusions must have a 1 micron in-line filter

- Mannitol vials must be drawn up using a filter needle

- In the presence of end stage renal disease mannitol may be harmful by causing an over expansion of intravascular fluid resulting in signs and symptoms of pulmonary edema and CHF.

Precautions and Side Effects:

- Angina, Tachycardia

- Electrolyte Abnormalities

- Hypo/Hypertension

- Pulmonary Edema, CHF

 

rev: 04/08