Generic Name:

Magnesium Sulfate

Trade Name:

Action:

Electrolyte Replacement
Antiarrhythmic

Indications:

Hypomagnesemia
Acute Phase of MI (initate during first 24 hours)
Eclampsia and Pre-eclampisa

Cerebral vasospasm

Administration Guidelines:

Usual Dosage Range and Route:

Magnesium Replacement : 0.5 - 5 G IV not to exceed 20 G IN A 24 hour period, rate should not exceed 150 mg / min

Cerebral vasospasm: 1-6 G/hr

Eclampsia and Pre-eclampsia 4-6G bolus over 20-30 minutes, then 2-4G Q one hour

Standard Concentrations:

** infuse each dose of magnesium sulfate over 1 to 2 hours **

** recheck level two hours post-infusion **

1G/100ml
2G / 100ml
40G/1000ml ( OB and Cerebral vasospasm)

Syringe based, variable flow, continuous microinfusion pump : centrally 1gm/10cc

EW Standard

1G/100ml
2G / 100ml

Special Considerations:

- Serum electrolyte levels should be known prior to therapy and monitored during magnesium infusion

* 500 mg = 4.06 meq = 2.03 mmol *

- Patients who present with the following clinical signs should not receive the infusion during the acute phase of MI.

¨ SBP < 100 mmHg
¨ HR < 50 bpm
¨ Second or Third degree AV block
¨ Cr > 2.5 mg/%

Precautions and Side Effects:

- Hypotension, treat with calcium gluconate 500 mg to 1 g.

- Severe flushing, sweating, heat sensation

- Cardiac depression, negative inotropy

- PR interval prolongation, av block. treat with atropine or pacemaker.

- Hypocalcemia