Generic Name:

Heparin

Trade Name:

Action:

Anticoagulant

Anti-thrombin III Co-Factor

Indications:

Unstable angina pectoris

Adjuvant therapy to thrombolysis

Status post ptca

Arterial / venous pulmonary thromboemboli

Disseminated intravascular coagulation

Administration Guidelines:

Usual Dosage Range and Route:

LOADING DOSE : 80 units/kg

*LOADING DOSE IS USUALLY GIVEN PRIOR TO STARTING MAINTENANCE*

MAINTENANCE DOSE : 500 to 1500 units/hour TO MAINTAIN PTT 1.5 - 2.5 times CONTROL

Wt. based dosing protocol: 80-100u/kg LD followed by 15-25 u/kg/hour to maintain target PTT.

Standard Concentration:

25,000 units / 250 ml 0.45% NaCl (PREMIXED)

MICROINFUSION: 25,000 units / 50 ml

EW Standard

25,000 units / 250 ml 0.45% NaCl (PREMIXED)

Special Considerations:

- Draw PTT prior to, 6 hours post initiation of therapy and 6 hours post any dosage adjustment

-PTT should be drawn twice daily during maintenance therapy

- Should be used with caution with any clinical state in which there is an increase risk of bleeding (e.g. gi bleed, post-op)

- approximately 100 units = 1mg (for cardiopulmonary bypass conversion)

Precautions and Side Effects

- Hemorrhage, bleeding from iv sites

- Anaphylaxis

- Type I and II thombocytopenia

-Increased risk of bleeding in patients on coumadin, aspirin, ticlopidine or plavix