Generic Name:

Fluconazole

Trade Name:

Diflucan

Action:

Fungistatic

Indications:

Fungal infection; candidiosis, Cryptococcal meningitis, Coccidioidal meningitis

IV requires infectious disease approval

Administration Guidelines:

Usual Dose and Route

Vulvogaginal candidiasis

-single oral dose at 150mg

Oropharyngeal or esophageal candidiasis

-load 400mg, maintenance 100-400mg PO/IV once daily

Systemic infection

-400-800mg PO/IV once daily

Standard Concentration:

200mg/ 100mL NS pre-mixed

400mg/ 200mL NS pre-mixed

Maximum rate is 200mg/hr

EW Standard

200mg/ 100mL NS pre-mixed

400mg/ 200mL NS pre-mixed

Maximum rate is 200mg/hr

Special Considerations:

- Flush lines with NS before and after administration.

- Dosage may need to be adjusted in patients with renal impairment

- Oral and IV doses are equivalent

Precautions and Side Effects:

- Hepatotoxoicity (rarely)

- Nausea, vomiting, headache