MASSACHUSETTS GENERAL HOSPITAL
Department of Pharmacy
Department of Nursing
Critical Care Guidelines
Generic Name: Fenoldopam
Trade Name: Cloropam®
Action: Rapid acting vasodilator, Selective DA-1 agonist with moderate a -2 agonist activity.
Indications: Severe hypertension(high dose)when other agents fail and a second line agent(low dose) for low urine output
Restrictions: Treatment duration of 48 hours and Unit Pharmacist approval.
Administration Guidelines:
Usual Dosage Range and Route:
Low urine out put (normotensive patient): 0.03mcg/kg/min (titration* not
required)
Hypertension: : Starting 0.03 - 0.1mcg/kg/min. NO bolus dose should be given.
Titrate to patient response
*Increase no faster than 0.05-0.1mcg/kg/min every 15 minutes. Max 1.6 mcg/kg/min.
Standard Concentration:
5mg/250 ml D5 or NS
Syringe based, variable flow, continuous microinfusion pump:
5mg/50ml,
20mg/50ml syringe
Special Considerations:
Monitor BP frequently
Monitor serum potassium and sodium
When treating hypertension, oral agents should be instituted as soon as possible.
Precautions and Side Effects:
Hypotension
Tachycardia
revised 09/03