Generic Name:

Desmopressin

Trade Name:

DDAVP

Action:

Synthetic Human Posterior Pituitary Hormone

Indications:

Diabetes Insipidus

Hemorrhaging associated with nephrotic syndrome

Management of perioperative bleeding in patients with a known bleeding diathesis

Administration Guidelines:

Usual Dosage Range and Route:

Standard Concentration:

Special Considerations:

Multiple infusions of desmopressin have been associated with a reduced response of uremic bleeding times. This suggests that maximal responses are achieved short-term. Additional doses may be minimally effective and may even increase the bleeding time.

- Serum and urinary electrolyte levels should be known prior to therapy and monitored during desmopressin administration

Precautions and Side Effects:

- Epistaxis, flushing

- Tachycardia

- Acute coronary syndrome

- Hypertension, hypotension

- Psychosis, headache

- Water retention, elevated serum potassium

- Abdominal cramps, Nasal Congestion