MASSACHUSETTS GENERAL HOSPITAL
Department of Pharmacy
Department of Nursing
Critical Care
| Generic Name: | Chlorpromazine |
| Trade Name: | Thorazine |
| Action: | Phenothiazine Antiemetic Antipsychotic |
| Indications: | Psychosis Intractable hiccups Nausea and Vomiting |
| Administration Guidelines: | |
| Usual Dose and Route: | Psychosis:
25 - 50 mg IV slow intravenous infusion
at a rate not to exceed 1 mg / minute every 1 to 4 hours
as needed and titrated to patient response. Dilute each dose to a concentration
less than or equal to 1 mg/ml using 0.9 % nacl only.
Nausea and Vomiting: 12.5 - 25mg IV q4 Hiccups: 10 - 25 mg IV slow intravenous infusion at a rate not to exceed 1 mg/minute three to four times daily. Dilute each dose to a concentration less than or equal to 1 mg/ml using 0.9 % NaCl only. |
| Special Considerations: | - Hematologic parameters including CBC,
WBC, platelets, and hematocrit should be monitored closely during extended therapy. - Caution: will potentiate actions and side effects of narcotics and other cns depressants |
| Precautions and Side Effects: | - Hypotension - Respiratory depression - Anticholinergic side effects:
- Extrapyramidal symptoms such as hyperreflexia, parkinson-like symptoms, motor restlessness - Urinary retention - Constipation - Agranulocytosis, leukopenia |
revised 09/03