MASSACHUSETTS GENERAL HOSPITAL
Department of Pharmacy
Department of Nursing
Critical Care
| Generic Name: | Amphotericin B |
| Trade Name: | Fungizone |
| Action: | Fungistatic or Fungicidal Depending on Organism and concentration of drug |
| Indications: | Treatment of Fungal Infections |
| Administration Guidelines: | |
| Usual Dosage Range and Route: | TEST DOSE: 1 mg in 50 ml OF
Dextrose 5% in water over 20 minutes. Observe for 4 hours for possible adverse reactions
INITIAL DOSE: 0.25 - 1mg/kg to max of 1.5mg/kg/day IV daily over at least 4 TO 6 hours. TOTAL DOSE: 1000 mg to 2500 mg over several weeks or months depending on type and severity of infection |
| Standard Concentration | 50 mg / 500 ml D5W Bladder irrigation 5mg/1000cc SWFI |
| Special Considerations: | -Test dose not required for bladder
irrigation - Patients may be pre-medicated with acetaminophen, hydrocortisone, and/or meperidine to ameliorate fever, chills, rigors - A second dose of acetaminophen and diphenhydramine may be administered halfway through infusion - Amphotericin is not compatible in 0.9% sodium chloride and with other electrolytes and drugs - Do not filter |
| Side Effects: | - Arrhythmias and anaphylactic like
reaction can occur - Fever, chills, nausea, vomiting, diarrhea, headache, malaise - Renal tubular acidosis, hypokalemia - Hepatotoxicity, blood dyscrasia |
revised 09/03