GENERIC NAME:

Aminocaproic acid

TRADE NAME:

Amicar

ACTION:

Inhibition of plasminogen activation and fibrinolysis

INDICATIONS:

- Hyperfibronolytic state status post surgery or trauma

- Hemophilia

- Hematuria status post urologic procedures

- Prophylaxis against hemorrhage in leukopenic patients recieving chemotherapy

- Antidote for hemmorrhage associated with thrombolytic therapy

Administration Guidelines:

Usual Dose and Route

LOAD : 4 - 5 G given over 1 hour

MAINTENANCE : 6 - 24 g given continuously over 24 hours

TOTAL 24 hour dose should not exceed 30 g

Standard Concentration:

Syringe: 12.5 G / 50ml

Central: 24 G / 500 ml

Peripheral: 6 G / 250 ml

     24 G / 500 ml

Special Considerations:

- Dosage adjustments may be required in:

- cardiac failure

- renal failure

- hepatic failure

- Should not be used in DIC except with concomittant heparin therapy

Precautions and Side Effects:

- Hypotension

- Bradycardia, bradyarrhythmias (may be caused by rapid infusion)

- Nausea, diarrhea, cramping, abdominal distention

- Dizziness, headache

- Elevated CPK, SGOT

- Thrombosis

-Intrarenal obstruction