Clinicopathological Conference (CPC's)

Year	Case #	Date Published	Citation	Diagnosis	Specialties	Patient History
CPC Archives 2000-2003 Go to: 1992-1995, or 1996-1999, or 2004-present
2000	1	1/13/2000	N Engl J Med 2000; 342: 115-122	Seminoma, retroperitoneal, consistent with retrogressed testicular seminoma.	Hematology/Oncology	A 27-year-old man was admitted to the hospital because of abdominal pain.
2000	2	1/20/2000	N Engl J Med 2000; 342: 192-199	Chronic hepatitis C with fibrosing cholestatic hepatitis (10 years after renal transplantation). Binswangers disease.	Infectious Disease	A 74-year-old man was admitted to the hospital because of recent, progressive jaundice.
2000	3	1/27/2000	N Engl J Med 2000; 342: 264-273	Systemic amyloidosis, AL type, with restrictive cardiomyopathy and involvement of the kidneys, spleen, larynx, blood vessels and peripheral nerves.	Cardiology/Cardiac Surgery	A 66-year-old woman with a nephrotic syndrome.
2000	4	2/10/2000	N Engl J Med 2000; 342: 414-420	Islet-cell carcinoma of the pancreas, low grade, producing corticotropin, with Cushing's syndrome and hypergastrinemia.	Gastroenterology, Abdominal Surgery	A 64-year-old man was admitted to the hospital because of hyperadrenocorticism.
2000	5	2/17/2000	N Engl J Med 2000; 342: 493-500	Disseminated Mycobacterium avium complex infection. Acquired immunodeficiency syndrome.	Infectious Disease	A 35-year-old man was admitted to the hospital because of a painful abdominal mass and fever.
2000	6	2/24/2000	N Engl J Med 2000; 342: 572-578	Epithelioid hemangioendothelioma of the lung (intravascular, sclerosing bronchioloalveolar tumor) with lymph-node metastasis.	Pulmonary; Thoracic Surgery; Vascular Medicine	A 20-year-old man was admitted to the hospital because of back pain and hemoptysis.
2000	7	3/9/2000	N Engl J Med 2000; 342: 722-728	Coombs'-positive hemolytic anemia associated with chronic ulcerative colitis.	Hematology/Oncology	A 23-year-old man was examined because of severe anemia, low grade fever and bloody diarrhea.
2000	8	3/16/2000	N Engl J Med 2000; 342: 801-806	Enteric duplication cyst communicating with the jejunum.	Gastroenterology, Abdominal Surgery	An 8 1/2 year old girl was admitted to the hospital because of an abdominal mass and pain.
2000	9	3/23/2000	N Engl J Med 2000; 342: 875-883	Erdheim-Chester disease involving multiple bones, with pathologic fractures and soft tissue masses.	Orthopedics/Musculoskeletal	A 41-year-old man was admitted to the hospital because of pain in multiple bones.
2000	10	3/30/2000	N Engl J Med 2000; 342: 957-965	Cerebral amyloid angiopathy with giant-cell inflammatory reaction to beta 4-amyloid and vasculitis.	Neurology; Vascular Medicine	A 63-year-old man was admitted to the hospital in early July because of rapidly progressive changes in behavior and ataxia.
2000	11	4/13/2000	N Engl J Med 2000; 342: 1110-1117	Pick's disease, type C.	Neurology	A 74-year-old man was referred to the Memory and Movement Disorders Unit because of progressive memory loss and personality changes.
2000	12	4/20/2000	N Engl J Med 2000; 342: 1196-1204	Leydig-cell tumor of the testis, estrogenic, with gynecomastia. Pituitary macroadenoma, gonadotroph type, non-functioning.	Endocrinology	A 60-year-old man was referred to the hospital because of a pituitary macroadenoma.
2000	13	4/27/2000	N Engl J Med 2000; 342: 1272-1278	Intussusception of the appendix into the cecum due to endometriosis.	Surgery; Gynecology	A 26-year-old woman was admitted to the hospital because of bouts of abdominal pain with vomiting, diarrhea, and hematochezia.
2000	14	5/11/2000	N Engl J Med 2000; 342: 1430-1438	Tularemic pneumonia.	Infectious Disease; Pulmonary	A 60-year-old man was admitted to the hospital because of pneumonia.
2000	15	5/18/2000	N Engl J Med 2000; 342: 1508-1514	Thymoma, predominantly cortical. Myasthenia gravis.	Neurology	A 69-year-old man was admitted to the hospital because of worsening myasthenia gravis and an anterior mediastinal mass.
2000	16	5/25/2000	N Engl J Med 2000; 342: 1590-1597	Hodgkin's disease, nodular-sclerosis type.	Oncology	A 53-year-old woman was admitted to the hospital because of swelling of the right breast and bilateral lymphadenopathy.
2000	17	6/8/2000	N Engl J Med 2000; 342: 1733-1740	Acute lobar nephronia	Urology, Pediatrics	A 21-week-old girl was admitted to the hospital because of fever.
2000	18	6/15/2000	N Engl J Med 2000; 342: 1814-1821	Intrathoracic fibromatosis (desmoid tumor).	Oncology; Pulmonary	A 45-year-old woman was admitted to the hospital because of a mass at the apex of her right lung.
2000	19	6/22/2000	N Engl J Med 2000; 342: 1893-1899	Primary sclerosing cholangitis involving the extra-hepatic bile ducts, gallbladder, and pancreas, with pseudocyst formation.	Gastroenterology, Pediatrics	A 17-year-old boy was admitted to the hospital because of obstructive jaundice and weight loss.
2000	20	6/29/2000	N Engl J Med 2000; 342: 1979-1987	Arrhythmogenic right ventricular dysplasia, fibro-fatty form.	Cardiology	A 61-year-old man was admitted to the hospital because of a wide-complex tachycardia and dyspnea.
2000	21	7/13/2000	N Engl J Med 2000; 343: 127-133	Crohn's disease of the stomach and the small and large intestines, with metastatic involvement of genital skin.	Gastroenterology, Abdominal Surgery; Pediatrics	A 13-year-old boy was admitted to the hospital three years and eight months before the diagnostic procedure because of abdominal pain.
2000	22	7/20/2000	N Engl J Med 2000; 343: 199-205	Adenocarcinoma, grade 2, of the distal esophagus, probably arising in Barrett's epithelium.	Thoracic Surgery	A 74-year-old man was referred to the hospital because of worsening dysphagia.
2000	23	7/27/2000	N Engl J Med 2000; 343: 281-287	Granulomatous osteomyelitis due to infection with Mycobacterium avium complex. Acquired immunodeficiency syndrome.	Infectious Disease	A 49-year-old man was admitted to the hospital because of pain in the knee.
2000	24	8/10/2000	N Engl J Med 2000; 343: 420-427	Neurocysticercosis, left temporal lobe, end stage, with calcification. Epilepsy.	Neurology/Neurosurgery	A 23-year-old man was admitted to the hospital because of partial seizures that had become generalized.
2000	25	8/17/2000	N Engl J Med 2000; 343: 493-500	Sarcoma of the intima of the pulmonary artery.	Pulmonary; Thoracic Surgery	A 69-year-old woman was admitted to the hospital because of a pulmonary arterial obstruction.
2000	26	8/24/2000	N Engl J Med 2000; 343: 563-570	Intraductal papillary mucinous carcinoma.	Surgery; Gastroenterology, Oncology	A 47-year-old man was admitted to the hospital because of recurrent abdominal pain and a pancreatic lesion.
2000	27	8/31/2000	N Engl J Med 2000; 343: 642-649	Granulomatous pneumonitis due to Mycobacterium avium complex infection, hypersensitivity reaction, or both.	Pulmonary; Infectious Disease	A 61-year-old man was admitted to the hospital because of increasing exertional dyspnea.
2000	28	9/14/2000	N Engl J Med 2000; 343: 794-800	Composite adenocarcinoma and high-grade neuroendocrine carcinoma of the rectum.	Surgery; Neuroendocrine, Gastroenterology	A 34-year-old man was admitted to the hospital because of ulcerative colitis with perirectal pain, swelling and discharge.
2000	29	9/21/2000	N Engl J Med 2000; 343: 870-877	Nocardiosis of the lungs, pleura, pericardium, and skin (in a renal transplant recipient).	Pulmonary	A 69-year-old woman was admitted to the hospital because of weakness, cough, and low-grade fever.
2000	30	9/28/2000	N Engl J Med 2000; 343: 953-961	Hypereosinophilic Churg-Strauss syndrome associated with the use of a CysLT1-receptor antagonist for asthma and with the withdrawal of corticosteroids.	Rheumatology; Allergy/Immunology; Pulmonary	A 25-year-old man was admitted to the hospital because of asthma, cardiac failure, diarrhea, and weakness of the right hand.
2000	31	10/12/2000	N Engl J Med 2000; 343: 1105-1111	Schistosomiasis of the urinary bladder (infection with S. haematobium).	Urology, Infectious Disease	A 32-year-old man was evaluated for a lesion of the urinary bladder.
2000	32	10/19/2000	N Engl J Med 2000; 343: 1168-1176	Pre-B-cell acute lymphoblastic leukemia (precursor B-lymphoblastic leukemia).	Orthopedics/Musculoskeletal; Pediatrics; Oncology	A boy who was six years and five months old was admitted to the hospital because of vertebral compression fractures.
2000	33	10/26/2000	N Engl J Med 2000; 343: 1249-1257	Precursor T-lymphoblastic lymphoma and early myeloid dysplastic syndrome after chemotherapy for peripheral rhabdomyosarcoma.	Pediatrics; Oncology	A seven-year-old girl was admitted to the hspital because of the superior vena cava syndrome.
2000	34	11/9/2000	N Engl J Med 2000; 343: 1399-1406	Granulomatous and lymphocytic hypophysitis.	Oncology; Neurosurgery	A 71-year-old woman was admitted to the hospital because of a pituitary mass.
2000	35	11/16/2000	N Engl J Med 2000; 343: 1477-1483	Diffuse large B-cell lymphoma, probably primary in the adrenal glands.	Oncology; Endocrinology, Surgery	A 82-year-old woman was admitted to the ambulatory care center because of bilateral adrenal masses and low-grade fever.
2000	36	11/23/2000	N Engl J Med 2000; 343: 1553-1561	Hepatocellular carcinoma, with a focal fibrolamellar pattern.	Oncology/Hematology	A 22-year-old man was admitted to the hospital because of a hepatic mass.
2000	37	11/30/2000	N Engl J Med 2000; 343: 1634-1638	Fibrous dysplasia.	Orthopedic Surgery; Orthopedics; Pediatrics	An 11-day-old boy was admitted to the hospital because of an osteolytic lesion in the right tibia.
2000	38	12/14/2000	N Engl J Med 2000; 343: 1788-1796	Pulmonary capillary hemangiomatosis.	Pulmonary	A 45-year-old woman was admitted to another hospital because of exertional dyspnea and bilateral pulmonary nodules.
2000	39	12/21/2000	N Engl J Med 2000; 343: 1876-1884	Aspergillus lung disease, with bronchocentric granulomatosis, interstitial (hypersensitivity) pneumonitis, fungal colonization of a preexisting emphysematous bulla, and probably invasive aspergillosis (radiologic evidence). Cytomegalovirus infection.	Pulmonary	A 47-year-old woman was admitted to the hospital because of bronchpulmonary disease.
2000	40	12/28/2000	N Engl J Med 2000; 343: 1951-1958	Pernicious anemia with atrophic gastritis. Gastric adenocarcinoma, mixed intestinal and diffuse types.	Gastroenterology, Internal Medicine	A 38-year-old woman was admitted to the hospital because of a tumor at the gastroesophageal junction.
2001	1	1/11/2001	N Engl J Med 2001; 344: 124-131	Biphasic synovial sarcoma, intraarticular.	Orthopedics/Musculoskeletal	A 26-year-old man was admitted to the hospital because of a mass in the knee.
2001	2	1/18/2001	N Engl J Med 2001; 344: 212-220	Pulmonary alveolar proteinosis.	Pulmonary; Thoracic Surgery	A 42-year-old woman admitted to the hospital because of worsening dyspnea and cough.
2001	3	1/25/2001	N Engl J Med 2001; 344 286-293	Invasive fungal sinusitis and osteomyelitis due to mucormycosis. (Diabetes mellitus.)	Infectious Disease	A 59-year-old man was admitted to the hospital because of right-sided visual loss and oculomotor-nerve palsy.
2001	4	2/8/2001	N Engl J Med 2001; 344: 443-449	Sarcoidosis, acute form (Lofgren's syndrome).	Infectious Disease; Pulmonary; Thoracic Surgery	A 26-year-old man was admitted to the hospital because of pain, erythema, and swelling of the legs.
2001	5	2/15/2001	N Engl J Med 2001; 344 510-517	Celiac disease.	Gastroenterology	A 52-year-old man was admitted to the hospital because of an attack of severe abdominal pain.
2001	6	2/22/2001	N Engl J Med 2001; 344 591-599	Acute cholestatic hepatitis associated with the use of 3,4-methylenedioxymethamphetamine (ecstasy).	Gastroenterology, Pediatrics	A 17-year-old girl was admitted to the hospital because of progressive jaundice and weight loss.
2001	7	3/8/2001	N Engl J Med 2001; 344 750-757	Melanotic neuroectodermal tumor of infancy, maxillary.	otolaryngology, Pediatrics	A 10-week-old boy was evaluated at MEEI because of progressive swelling in the region of the right side of the upper lip of two weeks duration.
2001	8	3/15/2001	N Engl J Med 2001; 344 832-839	Lymphoplasmacytic lymphoma. (Note: initially published with incorrect diagnosis.)	Neurology; Oncology	A 61-year-old man was admitted to the hospital because of transient quadriplegia and apnea.
2001	9	3/22/2001	N Engl J Med 2001; 344 917-923	Mononeuritis multiplex due to systemic amyloidosis.	Neurology	A 64-year-old, right-handed woman was admitted to the hospital because of motor and sensory impairment in her right arm.
2001	10	3/29/2001	N Engl J Med 2001; 344 997-1004	Rheumatoid lung disease, with rheumatoid nodules, pleuritis, and interstitial fibrosis.	Pulmonary; Oncology	A 53-year-old woman was admitted to the hospital because of radiographically evident pulmonary nodules.
2001	11	4/12/2001	N Engl J Med 2001; 344 1152-1158	Antiphospholipid-antibody syndrome, catastrophic, with renal thrombotic microangiopathy, due to systemic lupus erythematous. Lupus nephritis, mild.	Renal, Medicine	A 35-year-old woman was admitted to the hospital because of rapidly worsening renal failure.
2001	12	4/19/2001	N Engl J Med 2001; 344 1232-1239	Strychnine poisoning. Bipolar disease.	Pediatrics; Neurology	A 16-year-old boy was admitted to the hospital because of an altered mental and emotional status, and muscle rigidity.
2001	13	4/26/2001	N Engl J Med 2001; 344 1314-1320	Paraganglioma (pheochromocytoma) of the posterior mediastinum.	Ear, Nose & Throat; Endocrinology; Thoracic Surgery	A 19-year-old man admitted to the hospital because of headaches and hypertension.
2001	14	5/10/2001	N Engl J Med 2001; 344 1461-1466	Pyoderma gangrenosum associated with Crohn's disease of the colon.	Dermatology, Gastroenterology	A 47-year-old woman was admitted to the hospital for the third time because of painful, red swelling of the right foot.
2001	15	5/17/2001	N Engl J Med 2001; 344 1536-1542	Pituitary macroadenoma, clinically nonfunctioning. Pituitary apoplexy.	Endocrinology	A 72-year-old man was admitted to the hospital because of persistent fever and hypotension.
2001	16	5/24/2001	N Engl J Med 2001; 344 1622-1627	Infectious colitis due to Salmonella newport.	Gastroenterology, Pediatrics	A 17-year-old girl (gravida 1, para 1) wa admitted because of abdominal pain, fever, and diarrhea.
2001	17	5/31/2001	N Engl J Med 2001; 344 1701-1708	Sjogrens's syndrome involving the lungs, with follicular bronchiolitis, air trapping with cyst formation, and deposition of amyloid-like material.	Pulmonary; Thoracic Surgery	A 42-year-old man admitted because of pulmonary cysts.
2001	18	6/14/2001	N Engl J Med 2001; 344 1851-1856	Soft-tissue abcesses due to group A streptococcal infection.	Pediatrics; Infectious Disease; Rheumatology	A 19-month-old boy was admitted to the hospital because of a febrile illness and refusal to walk.
2001	19	6/21/2001	N Engl J Med 2001; 344 1929-1935	Systemic lupus erythematosus.	Rheumatology; Immunology	A 50-year-old man was admitted to the hospital because of fever and arthralgias.
2001	20	6/28/2001	N Engl J Med 2001; 344: 2009-2014	Brucellosis masked as moraxella.	Infectious Disease	A 64-year-old man was admitted to the hospital because of fever and bacteremia.
2001	21	7/12/2001	N Engl J Med 2001; 345: 126-131	Schistosomiasis (Schistosoma mansoni), involving the cerebral cortex.	Neurology; Infectious Disease	A 31-year-old man admitted to the hospital because of an apparent seizure and radiologic evidence of a cerebral lesion.
2001	22	7/19/2001	N Engl J Med 2001; 345: 201-205	Typhoid fever due to Salmonella enterica serotype typhi.	Infectious Disease	A 25-year-old woman wa admitted to the hospital because of persistent fever.
2001	23	7/26/2001	N Engl J Med 2001; 345: 276-281	Celiac disease.	Pediatrics; Gastroenterology, Abdominal Surgery	An 18-month old girl was admitted to the hospital because of diarrhea with intermittent constipation and vomiting.
2001	24	8/9/2001	N Engl J Med 2001; 345: 443-449	Bronchiolitis obliterans with organizing pneumonia (BOOP) overlapping chronic eosinophilic pneumonia, consistent with a clinical diagnosis of allergic bronchopulmonary aspergillosis. Allergic fungal sinusitis.	Pulmonary; Thoracic Surgery; Infectious Disease	A 46-year-old woman was admitted to the hospital because of recurrent hemoptysis.
2001	25	8/16/2001	N Engl J Med 2001; 345 526-532	Cytomegalovirus ileocolitis (and gastritis). (Immunosuppression after renal transplantation.)	Nephrology, Infectious disease, Gastroenterology	A 71-year-old man was admitted to the hospital because of diarrhea and abdominal pain
2001	26	8/23/2001	N Engl J Med 2001; 345: 596-605	Systemic sclerosis with scleroderma renal crisis. Acute interstitial nephritis, ? Drug induced. Polymyositis.	Rheumatology; Cardiology; Nephrology, infectious disease	A 67-year-old woman was initially admitted to this hospital because of hypertensive encephalopathy.
2001	27	8/30/2001	N Engl J Med 2001; 345 682-687	Lymphoplasmacytic lymphoma. Waldenstrom's macrobulinemia. Hyperviscosity syndrome. Cryobulinemia.	Oncology; Internal Medicine, Hematology, Immunology, Allergy	A 50-year-old man was admitted to the hospital because of marked spelomegaly and anemia.
2001	28	9/13/2001	N Engl J Med 2001; 345 817-823	Recurrent pyogenic cholangitis (Oriental cholangiohepatitis).	Immunology, Allergy, Gastroenterology	A 44-year-old woman was admitted to this hospital because of abdominal pain, chills, fever, and jaundice.
2001	29	9/20/2001	N Engl J Med 2001; 345 903-908	Osteosarcoma of the sacrum. Oncogenic rickets.	Orthopedics/Musculoskeletal; Oncology; Pediatrics	A 14-year-old boy was admitted to the hospital because of bone pain and skeletal abnormalities.
2001	30	9/27/2001	N Engl J Med 2001; 345 981-986	Vasculitis associated with antineutrophil cytoplasmic antibodies.	Rheumatology; Nephrology; Vascular Medicine	A 22-year-old man was admitted to the hospital because of fever, abdominal pain, diarrhea, and polyarthralgia.
2001	31	10/11/2001	N Engl J Med 2001; 345 1119-1124	Uremic small-artery disease with medial calcification and intimal hyperplasia (calciphylaxis).	Endocrinology, Nephrology	A 70-year-old woman was admitted to the hospital because of dyspnea and multiple cutaneous ulcers.
2001	32	10/18/2001	N Engl J Med 2001; 345 1193-1200	Usual interstitial pneumonitis with acute exacerbation, associated with rheumatoid arthritis.	Immunology, Allergy, Infectious Disease	A 77-year-old man was transferred to this hospital because of worsening bilateral air-space disease and acute renal failure.
2001	33	10/25/2001	N Engl J Med 2001; 345 1263-1269	Pulmonary mycobacterial infection (Mycobacterium kansasii). Traverse myelitis, probably immune mediated, with demyelinization. (Cutaneous rash of unknown cause.)	Pulmonary; Infectious Disease	A 33-year-old man was admitted to the hospital because of leg numbness and back pain.
2001	34	11/8/2001	N Engl J Med 2001; 345 1409-1415	Subcutaneous panniculitis-like T-cell lymphoma of gamma-delta T-cell derivation.	Oncology	A 54-year-old woman was admitted to the hospital with fever of unknown origin of one year's duration.
2001	35	11/15/2001	N Engl J Med 2001; 345 1483-1488	Non-small-cell carcinoma of the lung, metastatic to the hypothalamus, pituitary stalk, and pituitary gland.	Endocrinology	An 81-year-old man was transferred to the hospital because of bradycardia, hypothermia, and increasing confusion.
2001	36	11/22/2001	N Engl J Med 2001; 345: 1558-1565	Influenza pneumonia (type A influenza).	Pulmonary; Infectious Disease	A 57-year-old man was admitted to the hospital, for the sixth time, in January because of fever and cough.
2001	37	11/29/2001	N Engl J Med 2001; 345: 1627-1634	Ehrlichiosis, human granulocytic form.	Infectious Disease	A 76-year-old man was admitted to the hospital because of atrial fibrillation and increasing dyspnea.
2001	38	12/13/2001	N Engl J Med 2001; 345: 1758-1765	Lymphocytic meningitis and lymphocytic encephalomyelitis with sensory neuronopathy and ganglionitis. Small-cell carcinoma of the lung.	Neurology; Oncology	A 51-year-old woman was admitted to the hospital because of paresthesias, ataxic gait, and hallucinations.
2001	39	12/20/2001	N Engl J Med 2001; 345: 1833-1839	Diffuse beta-cell hyperplasia (nesidioblastosis) of the pancreas.	Endocrinology; Pediatrics	A two-day-old girl was admitted to the hospital because of persistent hypoglycemia.
2001	40	12/27/2001	N Engl J Med 2001; 345: 1901-1907	Traumatic perilymphatic fistula through the round window of the ear, with bacterial labyrinthitis and communication of the labyrinth with the cerebrospinal fluid compartment at an undetermined site. Meningitis due to Streptococcus pneumoniae.	Otolaryngology, Pediatrics	An eight-year-old boy was admitted to the Massachusetts Eye and Ear Infirmary because of fever, headache, vertigo and vomiting.
2002	1	1/10/2002	N Engl J Med 2002; 346: 115-122	Infection with Loa loa.	Infectious Disease	A 24-year-old woman was admitted to the Travel and Tropic Medicine Center at this hospital because of edema and intermittent paresthesias of the right leg.
2002	2	1/17/2002	N Engl J Med 2002; 346: 189-195	Bilateral, diffuse uveal melanocytic proliferation. Widely metastatic endometrial carcinoma, mixed epitheliod type, with endometrioid, muscinous, and undifferentiated patterns.	Ophthalmology; Oncology	A 58-year-old woman was elvaluated at the hospital because of loss of vision in her right eye.
2002	3	1/24/2002	N Engl J Med 2002; 346: 271-276	Primary sclerosing cholangitis. Crohn's disease.	Gastroenterology, Pediatrics	A 17-year-old boy was admitted to the hospital because of evidence of biliary obstruction.
2002	4	1/31/2002	N Engl J Med 2002; 346: 353-360	Glomerulnephritis mediated by anti-glomerular-basement-membrane and antibodies.	Nephrology	A 75-year-old man was admitted to the hospital because of acute renal failure.
2002	5	2/14/2002	N Engl J Med 2002; 346: 513-520	Langerhans'-cell histiocytosis.	Pediatrics; Hematology/Oncology; Neurology	A 15-year-old boy was admitted to the hospital because of a retro-orbital mass.
2002	6	2/21/2002	N Engl J Med 2002; 346: 603-610	Hyperviscosity syndrome due to IgG multiple myeloma.	Opthamology; Hematology/Oncology	A 54-year-old woman was admitted to the hospital because of occlusion of the central retinal vein in her left eye, followed by occlusion of the central retinal vein in her right eye.
2002	7	2/28/2002	N Engl J Med 2002; 346: 694-700	Metastatic parathyroid carcinoma.	Endocrinology, Oncology	A 47-year-old woman was admitted to the hospital because of recurrent hypercalcemia.
2002	8	3/14/2002	N Engl J Med 2002; 346: 843-850	Rheumatoid pleuritis.	Pulmonary; Thoracic Surgery	A 56-year-old woman was admitted to the hospital because of a persistent left-sided pleural effusion.
2002	9	3/21/2002	N Engl J Med 2002; 346: 924-929	Mucormycosis, rhino-orbital.	Opthamology; Neurology	An 80-year-old woman was admitted to the hospital because of sudden unilateral blindness.
2002	10	3/28/2002	N Engl J Med 2002; 346: 1009-1015.	Primary lymphoma of the central nervous system.	Neurology	A 52-year-old right-handed woman was admitted to the neurological clinic because of ataxia and fatigue.
2002	11	4/11/2002	N Engl J Med 2002; 346: 1152-1158.	Cardiac myxomas arising from the left atrium and the mitral-valve apparatus, consistent with Carney complex.	Cardiology; Endocrinology	A 27-year-old woman was admitted to the hospital because of syncope and two intracardiac masses.
2002	12	4/18/2002	N Engl J Med 2002; 346: 1232-1239	Infection with Fasciola hepatica.	Infectious Disease	A 50-year-old man was admitted to the Tropical and Geographic Medicine Center because of eosinophilia and fluctuating hepatic lesions.
2002	13	4/25/2002	N Engl J Med 2002; 346: 1309-1317.	Microembolic carcinoma in the lung, with pulmonary hemorrhage.	Pulmonary; Infectious Disease	A 43-year-old man was admitted to the hospital because of hemoptysis and dyspnea.
2002	14	5/9/2002	N Engl J Med 2002; 346: 1475-1482	Broncholithiasis due to histoplasmosis, with superinfection by actinomyces.	Infectious Disease; Pulmonary	A 51-year-old woman was admitted to the hospital because of recurrent hemoptysis.
2002	15	5/16/2002	N Engl J Med 2002; 346 1562-1570	Heparin-induced thrombocytopenia associated with extensive thrombosis (white-clot syndrome).	Cardiology; Renal	A 53-year-old man was admitted to the hospital because of a myocardial infarction.
2002	16	5/23/2002	N Engl J Med 2002; 346 1651-1658	Cerebral venous thrombosis, resulting in hemorrhagic infarction of the posterior left temporal lobe.	Neurology	A 41-year-old woman was admitted to the hospital because of an intracranial mass.
2002	17	5/30/2002	N Engl J Med 2002; 346 1732-1738	Lymphocytic myocarditis due to Borrelia burgdorferi infection (Lyme disease).	Cardiology; Infectious Disease	A 55-year-old man was admitted to the hospital because of second-degree atrioventricular block.
2002	18	6/13/2002	N Engl J Med 2002; 346 1892-1899	Wegener's granulomatosis, with microabscesses, capillaritis, granulomatous vasculitis, diffuse granulomatous tissue, and palisading granuloma.	Pulmonary; Vascular Medicine	A 48-year-old man was admitted to the hospital because of bilateral pulmonary infiltrates, bloody Sputum, and microhematuria.
2002	19	6/20/2002	N Engl J Med 2002; 346 1989-1996	Castleman's Disease, hyaline vascular type.	Otolaryngology	A 13-year-old girl was admitted to the Massachusetts Eye and Ear Infirmary because of a mass in the parotid gland.
2002	20	6/27/2002	N Engl J Med 2002; 346 2069-2076	East African trypanosomiasis (Trypanosoma brucei rhodesiense infection).	Infectious Disease	A 37-year-old man was admitted to the Tropical and Geographic Medicine Center because of fever and an inflamed foot.
2002	21	7/11/2002	N Engl J Med 2002; 347 122-130	Propylthioracil-induced, ANCA-positive vasculitis.	Rheumatology; Vascular Medicine	A 21-year-old man was admitted to the hospital because of inflammatory lesions of the foot.
2002	22	7/18/2002	N Engl J Med 2002; 347 200-206	Brucella melitensis infection.	Infectious Disease; Orthopedics, Musculoskeletal	A 37-year-old man was admitted to the hospital because of three weeks of intermittant fever and abdominal and back pain.
2002	23	7/25/2002	N Engl J Med 2002; 347 272-278	Giant-cell arteritis	Immunology and Rheumatology	A 73-year-old man was admitted to the hospital because of leg pains, occipital headaches, and night sweats.
2002	24	8/8/2002	N Engl J Med 2002; 347 430-436	Lichen planus.	Otolaryngology, Infectious Disease	A 48-year-old man admitted to the Massachusetts Eye and Ear Infirmary because of severe chronic oral lesions.
2002	25	8/15/2002	N Engl J Med 2002; 347 517-524	Cryptococcal sepsis, with pneumonia and meningitis.	Pulmonary; Infectious Disease	A 46-year-old woman was admitted to the hospital because of extensive pulmonary infiltrates.
2002	26	8/22/2002	N Engl J Med 2002; 347 601-606	ileocecal intussception due to colonic adenocarcinoma arising in a large villous adenoma.	Abdominal Surgery; Gastroenterology	An 87-year-old woman was admitted to the hospital because of abdominal pain, vomiting, bloody diarrhea, and an abdominal mass.
2002	27	8/29/2002	N Engl J Med 2002; 347 672-680	Neuronal ceroid lipofuscinosis, late-onset infantile subtype.	Neurology	A 5 1/2-year-old boy was admitted for video electroencephalographic monitoring to investigate his seizures.
2002	28	9/12/2002	N Engl J Med 2002; 347 831-837	Toxic shock syndrome due to group A streptococcus.	Infectious Disease	A 35-year-old woman was admitted to the hospital because of pain and swelling of the right thigh.
2002	29	9/19/2002	N Engl J Med 2002; 347 921-928	The antiphospholipid-antibody syndrome, with vascular thrombosis and infarction of the mitral-valve papillary muscle, causing acute mitral regurgitation.	Rheumatology; Cardiology/Cardiac Surgery; Vascular Medicine	A 17-year-old boy was admitted to the hospital because of acute mitral regurgitation and pulmonary edema.
2002	30	9/26/2002	N Engl J Med 2002; 347 1009-1017	Antimyeloperoxidase ANCA-associated vasculitis (microscopic polyangiitis), with pulmonary hemorrhage.	Pulmonary; Vascular Medicine	An eight-year-old girl was admitted to the hospital because of fever, cough, hemoptysis, and pulmonary consolidations.
2002	31	10/10/2002	N Engl J Med 2002; 347 1187-1194	Adenocarcinoma, probably of pancreaticobiliary origin and metastatic to the liver, with a hypercoaguable state resulting in thrombophlebitis and nonbacterial thrombotic endocarditis, with multiple embolic infarcts (Trousseau's syndrome).	Neurology/Neurosurgery; Hematology/Oncology	A 61-year-old man was admitted to the hospital because of right hemiplagia, aphasia, and obtundation.
2002	32	10/17/2002	N Engl J Med 2002; 347 1262-1268	Eosinophilic granuloma, late (burned-out) stage.	Pulmonary/Thoracic Surgery	A 58-year-old man was admitted to the hospital because of interstitial pulmonary disease.
2002	33	10/24/2002	N Engl J Med 2002; 347 1350-1357	Sarcoidosis with hilar and cervical lymphadenopathy (Lofgren's syndrome).	Pulmonary/Thoracic Surgery	A 28-year-old woman was admitted to the hospital because of ocular inflammation, fever and headache.
2002	34	10/31/2002	N Engl J Med 2002; 347 1433-1440	Acute disseminated encephalomyelitis.	Neurology/Neurosurgery; Infectious Disease	A 55-year-old right-handed man was admitted to the hospital because of difficulty with his handwriting and motor problems in his right leg.
2002	35	11/14/2002	N Engl J Med 2002; 347 1604-1611	Prolactinoma.	Endocrinology; Pediatrics	A nine-year-old right-handed girl was admitted to the hospital because of a suprasellar mass.
2002	36	11/21/2002	N Engl J Med 2002; 347 1693-1701	Idiopathic pulmonary hemosiderosis.	Pulmonary/Thoracic Surgery	A 32-year-old man was admitted to the hospital because of long-standing hemoptysis and interstitial pulmonary disease.
2002	37	11/28/2002	N Engl J Med 2002; 347 1783-1791	Acinar-cell carcinoma.	Surgery; Gastroenterology	A 69-year-old man was admitted to the hospital because of painful cutaneous nodules, elevated lipase levels, and abnormal results on abdominal scanning.
2002	38	12/12/2002	N Engl J Med 2002; 347 1952-1960	Diffuse large-B-Cell lymphoma, presenting in the liver.	Hematology/Oncology	A 54-year-old man was admitted to the hospital because of possible metastatic carcinoma with hypercalcemia and renal dysfunction.
2002	39	12/19/2002	N Engl J Med 2002; 347 2057-2065	Takayasu's arteritis.	Cardiology/Cardiac Surgery; Pulmonary/Thoracic Surgery; Vascular Surgery	A 35-year-old right-handed man was admitted to the hospital because of a persistent headache and deviation of the tongue.
2002	40	12/26/2002	N Engl J Med 2002; 347 2149-2157	Usual interstitial pneumonitis (fibrosing alveolitis) entering the accelerated phase, consistent with the clinical diagnosis of acute exacerbation of idiopathic pulmonary fibrosis.	Pulmonary/Thoracic Surgery	A 56-year-old man with rapidly worsening dyspnea.
2003	1	1/9/2003	N Engl J Med 2003; 348, 151-161	Mycobacterium tuberculosis infection.	Pulmonary/Thoracic Surgery	A 43-year-old man with fever and night sweats.
2003	2	1/16/2003	N Engl J Med 2003; 348, 243-249	Rheumatoid pericarditis.	Cardiology	A 60-year-old man with mild congestive heart failure of uncertain cause.
2003	3	1/23/2003	N Engl J Med 2003; 348, 333-342	Classic polyarteritis nodosa associated with hepatitis B infection.	Renal, Infectious Disease	A 36-year-old man with renal failure, hypertension, and neurologic abnormalities.
2003	4	1/30/2003	N Engl J Med 2003; 348, 447-455	Echinococcus granulosus infection.	Infectious Disease; Pulmonary	A 42-year-old woman with cough, fever, and abnormalities on thoracoabdominal computed tomography.
2003	5	2/13/2003	N Engl J Med 2003; 348, 630-637	Cutaneous eruption of acute systemic lupus erythematosus.	Dermatology	A 16-year-old girl with a rash and chest pain.
2003	6	2/20/2003	N Engl J Med 2003; 348, 735-743	Chronic inflammatory demyelinating polyradiculoneuropathy.	Neurology; Pediatrics	A 9-year-old girl with progressive weakness and areflexia.
2003	7	2/27/2003	N Engl J Med 2003; 348: 834-843	Pneumococcal pneumonia with endocarditis and endophthalmitis.	Infectious Disease; Pulmonary; Cardiology/Cardiac Surgery; Opthalmology	A 43-year-old man with fever, rapid loss of vision in the left eye, and cardiac findings.
2003	8	3/13/2003	N Engl J Med 2003; 348, 1033-1044	Acute humoral rejection, persistent.	Nephrology; Immunology	A 35-year-old man with early dysfunction of a second renal transplant
2003	9	3/20/2003	N Engl J Med 2003; 348, 1150-1158	Mediastinal germinoma	Hematology/Oncology	An 18-year-old man with back and leg pain and a nondiagnostic biopsy specimen
2003	10	3/27/2003	N Engl J Med 2003; 348, 1267-1275	Adult T-cell leukemia-lymphoma, HTLV-I-associated, acute form	Hematology/Oncology	A 72-year-old man with rapidly progressive leukemia, rash, and multiorgan failure
2003	11	4/10/2003	N Engl J Med 2003; 348, 1464-1476	Cholangiocarcinoma, with duodenal stricture.	Pediatrics; Gastroenterology/Abdominal Surgery; Oncology	A 14-year-old boy with ulcerative colitis, primary sclerosing cholangitis, and partial duodenal obstruction.
2003	12	4/17/2003	N Engl J Med 2003; 348, 1574-1585	Amiodarone-induced lung disease with bronchiolitis obliterans organizing pneumonia and interstitial pneumonitis.	Pulmonary	An 82-year-old man was admitted to the hospital because of dyspnea and pulmonary abnormalities.
2003	13	4/24/2003	N Engl J Med 2003; 348, 1692-1701	Langerhan's-cell histiocytosis	Hematology/Oncology	A 14-month-old boy with hepatomegaly, perianal lesions, and a bony lump on the forehead.
2003	14	5/8/2003	N Engl J Med 2003; 348, 1902-1912	Bronchiolitis obliterans with organizing pneumonia, causing the acute respiratory distress syndrome.	Pulmonary/Thoracic Surgery	A 73-year-old woman with pneumonia and progressive respiratory failure.
2003	15	5/15/2003	N Engl J Med 2003; 348, 2019-2028	Bronchiolitis obliterans with organizing pneumonia due to gastroesophageal reflux and occult aspiration.	Pulmonary/Thoracic Surgery	A 47-year-old man with waxing and waning pulmonary nodules five years after treatment for testicular seminoma.
2003	16	5/22/2003	N Engl J Med 2003; 348, 2125-2132	Brain abscess due to infection with Streptococcus milleri and Haemophilus aphrophilus.	Neurology; Infectious Disease	A 58-year-old woman with left-sided weakness and a right frontal brain mass.
2003	17	5/29/2003	N Engl J Med 2003; 348, 2239-2247	West Nile virus meningoencephalitis.	Infectious Disease	A woman with fever, headache and confusion.
2003	18	6/12/2003	N Engl J Med 2003; 348, 2443-2451	Hodgkins lymphoma, nodular sclerosis subtype, grade 2.	Oncology; Pulmonary	A girl with pain in the left leg and back, pruritus, and thoracic lymphadenopathy.
2003	19	6/19/2003	N Engl J Med 2003; 348, 2557-2566	Transient myeloproliferative disorder associated with mosaicism for trisomy 21.	Hematology/Oncology; Pediatrics	A newborn girl with leukocytosis and a worsening rash from birth.
2003	20	6/26/2003	N Engl J Med 2003; 348, 2669-2677	Gaucher's disease, type I	Hematology/Oncology; Pediatrics; Orthopedics	A girl with hepatosplenomegaly and pain in the thigh
2003	21	7/10/2003	N Engl J Med 2003; 349, 170-180	Giant-cell arteritis. Temporal arteritis	Neurology; Vascular Surgery	A man with repetitive strokes in the posterior circulation.
2003	22	7/17/2003	N Engl J Med 2003; 349, 287-295	Plasmodium vivax malaria	Infectious Disease	A 22-year-old man with chills and fever after a stay in South America.
2003	23	7/24/2003	N Engl J Med 2003; 349, 382-391	Paraneoplastic pemphigus secondary associated with gastric marginal-zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma).	Oncology; Gastroenterology, Oral Medicine, Dermatology	A 79-year-old woman with gastric lymphoma and erosive mucosal and cutaneous lesions
2003	24	7/31/2003	N Engl J Med 2003; 349, 486-494	Massive edema of the ovary with torsion.	Obstetrics, Gynecology, Women's Health	A 10-year-old girl with recurrent bouts of abdominal pain.
2003	25	8/14/2003	N Engl J Med 2003; 349, 691-700	Congenital cytomegalovirus infection.	Pediatrics; Infectious Disease	Newborn baby boy with whole body petechia.
2003	26	8/21/2003	N Engl J Med 2003; 349, 789-796	Encephalitis due to herpes simplex virus type 1 infection.	Infectious Disease	A 51-year-old man with fever, headache and a seizure.
2003	27	8/28/2003	N Eng J Med 1995; 349, 893-901	Sclerosing pancreatitis	Surgery; Gastroenterology	A 36-year-old man was referred to the hospital because of recurrent epigastric pain with persistently elevated amylase levels.
2003	28	9/11/2003	N Engl J Med 2002; 349: 1076-1082	Infiltrating lobar carcinoma of the right breast, two separate foci. Ductal carcinoma in situ of the right breast. Lobar carcinoma in situ and atypical ductal hyperplasia in both breasts. Mutation (6174delT) in the BRCA-2 gene.	Hematology/Oncology	A 51-year-old post-menopausal woman was admitted to the out-patient clinic because of breast carcinoma and a worrisome family history of malignancy.
2003	29	9/18/2003	N Engl J Med 2003; 349: 1169-1179	Lyme-Babesiosis	Internal Medicine, Infectious Disease	A 60-year-old man with fever, rigors and sweat.
2003	30	9/25/2003	N Engl J Med 2003; 349, 1267-1275	Ingestion of 1,4 -butanediol, resulting in y-hydroxybuterate intoxification.	Emergency Medicine	A man with sudden alteration in mental status.
2003	31	10/2/2003	N Engl J Med 2003; 349: 1369-1377	Diffuse large b-cell lymphoma of the heart, EBV-positive.	Oncology; Infectious Disease; Cardiology	A man with HIV infection and a right atrial mass.
2003	32	10/16/2003	N Engl J Med 2003; 349, 1555-1564	Atypical squamous cells of unknown significance (on the Papanicolaou smear), with a negative test for high-risk human papillomavirus.	OB/Gyn	A woman with atypical squamous cells on a Papanicolaou smear.
2003	33	10/23/2003	N Engl J Med 2003; 349, 1656-1663	Colchicine myoneuropathy	EMG; Neurology	A 37-year-old man with a long history of alcoholism, polysubstance abuse and major depression was brought to the hospital after he was found on the floor of his apt. covered with excrement.
2003	34	10/30/2003	N Engl J Med 2003; 349: 1750-1760	Attenuated familial adenomatous polyposis syndrome with a germ-line truncating mutation of the APC gene at codon 169. The patient does not have the mutation.	Gastroenterology	A 45-year-old woman admitted because of concerns about a family history of colonic polyps and cancer.
2003	35	11/13/2003	N Engl J Med 2003; 349, 1954-1961	Intraductal papillary mucinous carcinoma of the pancreas, arising in an intraductal papillary mucinous neoplasm and involving both the main pancreatic duct and a side branch.	Gastroenterology, Surgery	A 75-year-old man with a cystic lesion of the pancreas.
2003	36	11/20/2003	N Engl J Med 2003; 349, 2055-2063	Acute granulomatous interstitial nephritis with tubular injury and minimal-change disease, due to a reaction to ibuprofen	Renal	A woman with impaired renal function
2003	37	11/27/2003	N Engl J Med 2003; 349, 2147-2155	Colonic necrosis with perforation due to sodium polystyrene sulfonate in sorbitol. Ischemic colitis, healed.	Gastroenterology, Renal	A man with coronary artery disease, peripheral vascular disease, end-stage renal disease, and abdominal pain and distention.
2003	38	12/11/2003	N Engl J Med 2003; 349: 2341-2349	Meningoencephalitis and sepsis due to Nisseria meningitidis infection.	Infectious Disease; Pediatrics; Neurology	A girl with fever and coma.
2003	39	12/18/2003	N Engl J Med 2003; 349: 2442-2447	Inflammatory pseudotumor	Urology	A woman with gross hematuria.
2003	40	12/25/2003	N Engl J Med 2003; 349: 2541-2549	Tuberculous enterocolitis	Pediatrics; Gastroenterology	A boy with recurrent abdominal distention and diarrhea.