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Our Center

Jianren Mao, M.D., Ph.D. Director,
MGH Center for Translational Pain Research

Current Challenges in Translational Pain Research

Vice Chair for Research, Department of Anesthesia, Critical Care and Pain Medicine
Richard J. Kitz Professor of Anesthesia Research, Harvard Medical School

Dr. Mao’s Selected Bibliography

Selected peer-reviewed publications (from over 130 publications)
Mao J, Mayer DJ, Price DD. Patterns of increased brain activity indicative of pain in a rat model of peripheral mononeuropathy. J Neurosci 1993; 13:2689-2702.

Mao J, Price DD, Mayer DJ. Thermal hyperalgesia in association with the development of morphine tolerance: roles of excitatory amino acid receptors and protein kinase C. Journal of Neurosci 1994; 14:2301-2312.

Mao J, Sung B, Ji RR, Lim G. Neuronal apoptosis associated with morphine tolerance: evidence for an opioid-induced neurotoxic mechanism. Journal of Neurosci 2002; 22:7650-7661.

Mao J, Sung B, Ji RR, Lim G. Chronic morphine induces downregulation of spinal glutamate transporters: implications in morphine tolerance and abnormal pain sensitivity. Journal of Neurosci 2002; 22:8312-8323.

Sung B, Lim G, Mao J. Altered expression and uptake activity of spinal glutamate transporters following nerve injury contributes to the pathogenesis of neuropathic pain in rats, Journal of Neurosci 2003; 23;2899-2910.

Ballantyne J, Mao J. Opioid therapy for chronic pain. New England Journal of Medicine 2003; 349:1943-1953.

Wang S, Lim G, Zeng Q, Yang L, Sung B, Mao J. Expression of spinal glucocorticoid receptors following peripheral nerve injury contributes to neuropathic pain behaviors in rats. Journal of Neurosci 2004; 24:8595-8605.

Wang S, Lim G, Zeng Q, Yang L, Sung B, Mao J. Central glucocorticoid receptors modulate the expression and function of spinal NMDA receptors after peripheral nerve injury. Journal of Neurosci 2005; 25:488-495.

Lim G, Wang S, Zeng Q, Sung B, Yang L, Mao J. Expression of spinal NMDA receptor and PKCg after chronic morphine is regulated by spinal glucocorticoid receptor. Journal of Neurosci 2005; 25:11145-11154.

Yang L, Wang S, Sung B, Lim G, Mao J. Morphine induces ubiquitin-proteasome activity and glutamate transporter degradation. Journal of Biological Chemistry 2008; 283:21703-21713.

Lim G, Wang S, Zhang Y, Tian YH, Mao J. Spinal leptin contributes to the pathogenesis of neuropathic pain. Journal of Clinical Investigation 2009; 119:295-304.

Tian Y, Wang S, Ma Y, Lim G, Kim H, Mao J. Leptin enhances NMDA-induced spinal excitation in rats: a functional link between adipocytokine and neuropathic pain. Pain, 2011, 152:1263-1271.

Kim H, Chen L, Lim G, Sung B, Wang S, McCabe MF, Rusanescu G, Yang L, Tian Y, Mao J. Brain indoleamine 2, 3 dioxygenase contributes to the comorbidity of pain and depression. Journal of Clinical Investigation, 2012, 122:2940-2954.

Wang S, Tian Y, Song L, Lim G, Tan Y, Chen L, Mao J. Exacerbated mechanical hyperalgesia in rats with genetically predisposed depressive behavior: role of melatonin and NMDA receptors. Pain, 2012, Sept 28 [ePub ahead of print]

Mao J. Current challenges in translational pain research. Trends Pharmacol Sci. 2012 Nov;33(11):568-73. doi: 10.1016/j.tips.2012.08.001. Epub 2012 Sep 6.

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