Our Center

Jianren Mao, M.D., Ph.D. Director,
MGH Center for Translational Pain Research

Translational Pain Research PDF

Assistant Anesthetist, Department of Anesthesia and Critical Care
Associate Professor, Harvard Medical School

Dr. Mao’s Selected Bibliography

Mao J, Price D, Mayer D, Lu J, Hayes R. Intrathecal MK 801 and local nerve anesthesia synergistically reduce nociceptive behaviors in rats with experimental peripheral mononeuropathy. Brain Res 1992;576:254-262.

Mao J, Price D, Hayes R, Mayer D. Spatial patterns of increased spinal cord membrane-bound protein kinase C and their relation to increases in neural activity in rats with painful peripheral mononeuropathy. J Neurophysiol 1993;70:470-481.

Mao J, Mayer D, Price D. Patterns of increased brain activity indicative of pain in a rat model of peripheral mononeuropathy. J Neurosci 1993;13:2689-2702.

Mao J, Price D, Hayes R, Lu J, Mayer D, Frenk H. Intrathecal treatment with dextrorphan and ketamine potently reduce pain-related behaviors in a rat model of painful peripheral mononeuropathy. Brain Res 1993;605:163-168.

Mao J, Price D, Mayer D. Thermal hyperalgesia in association with the development of morphine tolerance: roles of excitatory amino acid receptors and protein kinase C. J Neurosci 1994; 14:2301-2312. Mao J, Price DD, Mayer DJ. Experimental mononeuropathy reduces the antinociceptive effects of morphine: implications for common intracellular mechanisms involved in morphine tolerance and neuropathic pain. Pain 1995;61:353-364 (with editorial).

Mao J, Price D, Mayer D. Mechanisms of hyperalgesia and morphine tolerance: A current view of their possible interactions. Pain 1995; 62:259-274.

Mao J, Price D, Zhu J, Lu J, Mayer D. The inhibition of nitric oxide-activated poly(ADP-ribose) synthetase attenuates transsynaptic alteration of spinal cord dorsal horn neurons and neuropathic pain in the rat. Pain 1997;72:355-366.

Mayer D, Mao J, Holt J, Price D. Cellular mechanisms of neuropathic pain, morphine tolerance, and their interactions, Proc Natl Acad Sci USA, 1999; 96:7731-7736.

Mao J. NMDA and opioid receptors: their interactions in antinociception, tolerance, and neuroplasticity, Brain Res Rev 1999; 30:289-304.

Mao J, Mayer D. Spinal cord neuroplasticity following repeated opioid exposure and its relation to pathological pain, Ann NY Acad Sci 2001; 933:175-184.

Mao J, Sung B, Ji R, Lim G. Chronic morphine induces down-regulation of spinal glutamate transporters: implications in morphine tolerance and abnormal pain sensitivity, J Neurosci 2002; 22:8312-8323.

Mao J, Sung B, Ji R, Lim G. Neuronal apoptosis associated with morphine tolerance: evidence for an opioid-induced neurotoxic mechanism, J Neurosci 2002; 22: 7650-7661.

Sung B, Lim G, Mao J: Altered expression and uptake activity of spinal glutamate transporters following peripheral nerve injury contributes to the pathogenesis of neuropathic pain in rats. J Neurosci 2003; 23:2899-2910.

Wang S, Lim G, Zeng Q, Yang L, Sung B, Mao J. Expression of spinal glucocorticoid receptors following peripheral nerve injury contributes to neuropathic pain behaviors in rats. J Neurosci 2004; 24:8595-8605.

Wang S, Lim G, Zeng Q, Yang L, Sung B, Mao J. Central glucocorticoid receptors modulate the expression and function of spinal NMDA receptors after peripheral nerve injury. J Neurosci 2005; 25(2), 488-95.

Lim G, Wang S, Zeng Q, Sung B, Mao J: Spinal glucocorticoid receptors contribute to the development of morphine tolerance in rats. Anesthesiol 2005; 102(4),832-37.

Lim G, Wang S, Zeng Q, Sung B, Mao J: Evidence for a long-term influence on morphine tolerance after previous morphine exposure: a role of neuronal glucocorticoid receptors. Pain 2005; 114: 81-92 (with Editorial).

Lim G, Wang S, Zeng Q, Sung B, Yang L, Mao J. Expression of spinal NMDA receptor and PKCg after chronic morphine is regulated by spinal glucocorticoid receptors. J Neurosci 2005; 25:11145-54.

Wang S, Lim G, Yang L, Sung B, Mao J. Downregulation of spinal glutamate transporter EAAC1 following nerve injury is regulated by central glucocorticoid receptors in rats. Pain 2006; 120:78-85.

Clinical Area

Price D, Mao J, Frenk H, Mayer D. The N-methyl-D-aspartate receptor antagonist dextromethorphan selectively reduces the temporal summation of the second pain in man. Pain, 1994; 59:165-174 (with editorial).

Mao J, Chen L. Systemic lidocaine for neuropathic pain relief: a critical review, Pain 2000; 87:7-17.

Mao J, Chen L. Gabapentin in pain management 2000; Anesth & Analg, 91:680-687.

Mao J. Translational pain research: bridging the gap between basic and clinical research, Pain, 2002; 97:183-187.

Mao J. Opioid-induced abnormal pain sensitivity: Implications in clinical opioid therapy. Pain, 2002; 100:213-217.

Ballantyne J, Mao J. Opioid therapy for chronic pain. New Eng J Med, 2003; 349:1943-53.

Hord E, Stojanovic M, Vallejo R, Barna S, Santiago-Palma J, Mao J: Multiple Bier blocks with labetalol for complex regional pain syndrome refractory to other treatments. J Pain Sympt Manage 2003; 25:299-302.

Cohen S, Mao J: Is the analgesic effect of systemic lidocaine mediated through opioid receptors? Acta Anaesthesiol Scan 2003; 47:910-11.

Cohen S, Chang A, Larkin T, Mao J: The IV Ketamine Test: A predictive response tool for oral dextromethorphan treatment in neuropathic pain. Anesth Analg 2004; 99:1753-59.

Mao J. NMDA receptor and pain management. Int J Pain Med & Pall Care, 2005, 3:101-4.

Mao J. Central glucocorticoid receptor: a new role in the cellular mechanisms of neuropathic pain, Rev Neurosci, 2005, 16:233-38.

Mao J. Opioid therapy and opioid-induced pain: implications in headache treatment. Current Pain and Headache Reports, 2006, 10:67-70.

Mao J. Opioid tolerance, dependence, and opioid-induced hyperalgesia. Psyc Ann, 2006

Cohen S, Larkin T, Mao J. The IV ketamine test predicts subsequent response to an oral dextromethorphan treatment regimen in fibromyalgia patients – A clinical trial. J Pain 2006; In press

Books

Mao J (Editor): Translational Pain Research, Volume I, Nova Sciences Publishers, New York; 2006, in press

Mao J (Editor); Translational Pain Research, Volume II, Nova Sciences Publishers, New York; 2006, In press

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Research Interest

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Lucy Chen, M.D.

Assistant in Anesthesia, Department of Anesthesia and Critical Care
Instructor, Harvard Medical School

Dr. Chen’s Selected Bibliography

Journal Articles

1. Mao J., Chen, L.L. Systemic lidocaine for neuropathic pain relief, Pain, 2000,87:717.

2. Mao J., Chen, L.L. Gabapentin in pain management, Anesthesia &Analgesia, 2000, 91:680-687.

3. Shaff D., Raines D., Vidal Melo M., Ling M.E., Misra S., Chen, L.L. Anesthetic management for transurethral resection of the bladder in a 74-year-old male with uncorrected Tetralogy of Fallot. Journal of Clinical Anesthesia, 2005, 17; 198 201.

4. Singla A, Stojanovic M., Chen, L.L., Mao J., Hyperalgesia from intrathecal morphine infusion, Anesthesia &Analgesia, 2007, in press

5. Chang, G., Chen, L.L., Mao J. Opioid tolerance and hyperalgesia. Medical Clinics of North America 2007, 91:199-211.

Book Chapters

1. Mao J, Chen L.L. Opioid tolerance and dependence. In: Drugs for Pain, Eds: H. Smith Ed, Hanley & Belfus, 2002, pp. 153-157.

2. Chen, L.L, Ballantyne, J Pediatric postoperative pain In Massachusetts General Hospital Pain Management Hand Book, Ed: Ballantyne JC; Third edition. 2005, pp. 302-317.

3. Field, J, Chen, L.L, Pan-Smith, M. Acupuncture in Massachusetts Genera Hospital Pain Management Hand Book, Ed: Ballantyne JC; Third edition. 2005, pp. 248-256.

4. Chen, L.L. Ion channel blocker in pain management, Translational Pain Research, Ed: Mao J; 2006; pp. 25-43.

5. Chen, L.L. Complimentary and alternative medicine in pain management. Translational Pain Research, Ed: Mao J; 2006; pp. 317-330.

6. Chen, L.L. Mao J. Opioid tolerance and pain management, Pain Management, Ed: Smith H. 2007, in press

Abstracts

1. Ahmed SU, Hord ED, Vallejo R, Chen L,L Dubois BW, Mao J. Pain relief after lumbar epidural steroid injection (ESI), IASP Abstract, 2002; 214-P21 0

2. Santiago-Palma J, Barna S, Vallejo R, Chen L, Mao J, Ahmed SUo Opioid rotation in the management of chronic non-cancer pain: preliminary results of an analysis of dose ratios between methadone and controlled release oxycodone (eRO), 'ASP Abstract, 2002; 1681-P229

3. Barna S, Santiago-Palma J, Hord ED, Chen L, Mao J, Ahmed SU, Methadone asa firstlinelong-actingopioidforthetreatmentofchronicnon-cancerpain, IASP Abstract, 2002; 1682:P230.

Clinical Communication and Teaching Materials

1. Chen L.L. Guidelinesfor IncidentReport for MGHPainCenter Q&A Committee; Department of Anesthesia and Critical Care, MGH, 2003; revised 2004;

2. Chen L.L., Manual for Clinical Pediatric Pain Assessment; Massachusetts General Hospital; 2004;

3. ChenL.L. IntroductoryofAcupunctureTreatmentforPainManagement; Massachusetts General Hospital; 2004;

4. ChenL.L.,ClinicalStepsforOpioidWeaningforPediatricICUPatients; Massachusetts General Hospital, 2005;

5. Chen L.L., Clinical Steps for Sedatives Weaning for Pediatric Pain ICU Patients; Massachusetts General Hospital, 2005;

6. Chen L.L. Goalandobjectives forAnesthesia ResidentRotationthrough MGH PainCenter; DepartmentofAnesthesiaandCritical Care, MGH,2004; revised 2005;

7. Chen. L.L. Acupuncture in pain management. Pain Management rounds. 2005 volume 2, issue 7(CME credit. approved by the Harvard Medical School Department of Continuing Education)

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Research Interest

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