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Research Interests

 

 


Jianren Mao, M.D., Ph.D. Director,
MGH Center for Translational Pain Research

Current Challenges in Translational Pain Research

Vice Chair for Research, Department of Anesthesia, Critical Care and Pain Medicine
Richard J. Kitz Professor of Anaesthesia Research, Harvard Medical School

Dr. Mao’s Selected Bibliography

Selected peer-reviewed publications (from over 130 publications)
Mao J, Mayer DJ, Price DD. Patterns of increased brain activity indicative of pain in a rat model of peripheral mononeuropathy. J Neurosci 1993; 13:2689-2702.

Mao J, Price DD, Mayer DJ. Thermal hyperalgesia in association with the development of morphine tolerance: roles of excitatory amino acid receptors and protein kinase C. Journal of Neurosci 1994; 14:2301-2312.

Mao J, Sung B, Ji RR, Lim G. Neuronal apoptosis associated with morphine tolerance: evidence for an opioid-induced neurotoxic mechanism. Journal of Neurosci 2002; 22:7650-7661.

Mao J, Sung B, Ji RR, Lim G. Chronic morphine induces downregulation of spinal glutamate transporters: implications in morphine tolerance and abnormal pain sensitivity. Journal of Neurosci 2002; 22:8312-8323.

Sung B, Lim G, Mao J. Altered expression and uptake activity of spinal glutamate transporters following nerve injury contributes to the pathogenesis of neuropathic pain in rats, Journal of Neurosci 2003; 23;2899-2910.

Ballantyne J, Mao J. Opioid therapy for chronic pain. New England Journal of Medicine 2003; 349:1943-1953.

Wang S, Lim G, Zeng Q, Yang L, Sung B, Mao J. Expression of spinal glucocorticoid receptors following peripheral nerve injury contributes to neuropathic pain behaviors in rats. Journal of Neurosci 2004; 24:8595-8605.

Wang S, Lim G, Zeng Q, Yang L, Sung B, Mao J. Central glucocorticoid receptors modulate the expression and function of spinal NMDA receptors after peripheral nerve injury. Journal of Neurosci 2005; 25:488-495.

Lim G, Wang S, Zeng Q, Sung B, Yang L, Mao J. Expression of spinal NMDA receptor and PKCg after chronic morphine is regulated by spinal glucocorticoid receptor. Journal of Neurosci 2005; 25:11145-11154.

Yang L, Wang S, Sung B, Lim G, Mao J. Morphine induces ubiquitin-proteasome activity and glutamate transporter degradation. Journal of Biological Chemistry 2008; 283:21703-21713.

Lim G, Wang S, Zhang Y, Tian YH, Mao J. Spinal leptin contributes to the pathogenesis of neuropathic pain. Journal of Clinical Investigation 2009; 119:295-304.

Tian Y, Wang S, Ma Y, Lim G, Kim H, Mao J. Leptin enhances NMDA-induced spinal excitation in rats: a functional link between adipocytokine and neuropathic pain. Pain, 2011, 152:1263-1271.

Kim H, Chen L, Lim G, Sung B, Wang S, McCabe MF, Rusanescu G, Yang L, Tian Y, Mao J. Brain indoleamine 2, 3 dioxygenase contributes to the comorbidity of pain and depression. Journal of Clinical Investigation, 2012, 122:2940-2954.

Wang S, Tian Y, Song L, Lim G, Tan Y, Chen L, Mao J. Exacerbated mechanical hyperalgesia in rats with genetically predisposed depressive behavior: role of melatonin and NMDA receptors. Pain, 2012, Sept 28 [ePub ahead of print]

Mao J. Current challenges in translational pain research. Trends Pharmacol Sci. 2012 Nov;33(11):568-73. doi: 10.1016/j.tips.2012.08.001. Epub 2012 Sep 6.

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Lucy Chen, M.D.

Assistant Anesthetist, Department of Anesthesia, Critical Care and Pain Medicine
Assistant Professor, Harvard Medical School

Dr. Chen’s Selected Bibliography

Research Investigations

Cohen SP, Christo PJ, Wang S, Chen L, Stojanovic MP, Sheilds CH, Brummett C, Mao J. The effect of opioid dose and treatment duration on the perception of a painful standardized clinical stimulus. Reg Anesth Pain Med 2008;33:199-206.


Cohen, SP, Wang S, Chen L, Kurihara C, McKnight G, Marcuson M, Mao J. An intravenous Ketamin test as predictive response tool in opioid tolerant patients, J Pain Symptom Manage 2009;37:698-708.


Chen L,  Malarick C, Seefeld L, Wang S, Houghton M, Mao J. Altered quantitative testing outcome in subjects with chronic opioids.  Pain 2009; 143:65-70.


Chen L, Houghton M, Seefeld L, Malarick C, Mao J. A survey of selected physician’s views on acupuncture in pain management. Pain Med 2010 Apr;11(4):530-534.


Chen L, Houghton M, Seefeld L, Malarick C, Mao J.  Opioid therapy for chronic pain: physicians’ attitude and practice patterns.  J Opioid Manag 2011 Jul-Aug; 7(4):267-276.


Wang S, Zhang L, Ma Y, Chen L, Tian Y, Mao J, Martyn JJ. Nociceptive behavior following hindpaw burn injury in young rats: response to systemic morphine. Pain Med 2011 Jan; 12(1):87-98.


Kim H, Chen L, Lim G, Sung B, Wang S, McCabe M, Rusanescu G, Yang L, Tian Y, Mao J. Brain indoleamine 2, 3-dioxygenase regulates the comorbidity of pain and depression. J Clin Invest 2012 Aug 1;122(8):2940-2954. doi: 10.1172/JCI61884. Epub 2012 Jul 2.


Wang S, Li S, Tan Y, Ma Y, Tian Y, Jin X, Lim G, Zhang S, Chen L, Mao J. A functional relationship between trigeminal astroglial activation and NR1 expression in a rat model of temporomandibular joint inflammation.  Pain Med. 2012 Dec;13(12):1590-600.doi: 10.1111/j.1526-4637.2012.01511.x.Epub2012 Oct 30.


Chen L, Vo T,  Seefeld L, Malarick C, Houghton M, Mao J, Lack of correlation between opioid dose adjustment and pain score change during chronic opioid therapy.  J Pain  2013 Apr:14(4):384-92. doi: 10.1016/j.jpain.2012.12.012.Epub2013 Feb26.


Cohen SP, Mao J, Strassels SA, Vu TN, Gupta A, Erdek MA, Christo PJ, Kurihara C, Griffith SR,  Chen L. Does pain score in response to a standardized subcutaneous local anesthetic injection predict epidural steroid injection outcomes in patients with lumbosacral radiculopathy: a prospective correlative study. Pain Med.2013 Mar;14(3):327-35.doi:10.1111/pme.12027.Epub 2013 Jan 7


Wang S, Tian Y, Song L, Lim G, Tan Y, Yu Z, Chen L, Mao J.  Exacerbated mechanical hyperalgesia in rats with genetically pre-disposed depressive behavior: role of melatonin and NMDA receptors.  Pain.2012 Dec;153(12):2448-57.doi:10.1016/j.pain.2012.08.016.Epub 2012 Sep 28


Other peer-reviewed publications


Mao J, Chen L. Systemic lidocaine for neuropathic pain relief, Pain 2000;87:7-17.


Mao J, Chen L. Gabapentin in pain management, Anesth Analg 2000;91:680-687.


Shaff D, Raines D, Vidal Melo M, Ling ME, Misra S, Chen L. Anesthetic management for transurethral resection of the bladder in a 74-year-old male with uncorrected Tetralogy of Fallot. J Clin Anesth 2005; 17:198-201.


Singla A, Stojanovic M, Chen L, Mao J. Hyperalgesia from intrathecal morphine infusion, Anesth Analg 2007;105;1816-1819.


Chang G, Chen L, Mao J. Opioid tolerance and hyperalgesia. Med Clin of North Am 2007; 91:199-211.


Vorobeychik Y, Chen L, Mao J. Improved opioid analgesic effect after opioid dose reduction.  Pain Medicine 2008; 9(6):724-727.


Chen L. Acupuncture in current pain management. NAJMS 2010; 3(4):212-220.


Vorobeychik Y, Gordin V, Mao J, Chen L. Combination therapy for neuropathic pain, CNS Drugs, 2011 Dec 1;25(12):1023-1034.


Book chapters


Mao J, Chen L. Opioid tolerance and dependence. In: Smith H, editor.  Drugs for pain. Philadelphia: Hanley & Belfus; 2002. p. 153-156.


Chen L, Ballantyne, J. Postoperative Pain in Children. In: Ballantyne JC, editor. Massachusetts General Hospital pain management hand book, Third edition. Philadelphia: Lippincott Williams & Wilkins; 2006. p. 302-316.


Field J, Chen L, Pian-Smith M. Acupuncture. In: Ballantyne JC, editor. Massachusetts General Hospital pain management hand book, Third edition. Philadelphia: Lippincott Williams & Wilkins; 2006. p. 248-255.


Chen L. Ion channel blocker in pain management. In: Mao J, editor. Translational pain research. New York: Nova Science Publishers; 2006. p. 25-43.


Chen L. Complimentary and alternative medicine in pain management. In: Mao J, editor. Translational pain research. New York: Nova Science Publishers; 2006. p. 317-330.


Chen L. Mao J. Clinical issues of opioid therapy in chronic pain management. In: Smith H, editor. Current therapy in pain. Philadelphia: Sauders Elsevier; 2009. p. 114-123.


Mao J, Chen L. Opioid tolerance. In: Smith H, Passik S, editors. Pain and chemical dependency. New York: Oxford University Press; 2008. p. 109-111.


Chen L. Complimentary and alternative medicine. In: Abdi S, Chopra D, and Smith H, editors. McGraw-Hill Specialty Board Review Pain Medicine. Philadelphia: MaGraw-Hill; 2009. p. 231-235.


Miller N, Chen L, Mao J. Prescription of opiate medication: clinical assessment and treatment for tolerance and dependence. In: Norman S Miller, Mark S Gold, MD, editors. Addictive disorders in medical populations. Oxford: Wiley-Blackwell; 2010. p. 227-238.


Chen L, Cohen S, Mao J. Opioid medicine for the primary care physician. In: Brummett C and Cohen S, editors. Pain medicine for the primary care physician. New York, Oxford University Press; 2012. In press.


Chen L, Mao J. Opioid induced hyperalgesia. In: Smith H, editor. Opioid therapy in the 21st century. New York: Oxford University Press; 2012. In press.


Chen L. Acupuncture in current pain management. In: Chen L, editor. Acupuncture in modern medicine. Rijeka, Croatia: InTech; 2012. In press.


Chen L, Mao J. Non-opioid pain medications.  In: Ronald D. Miller, editor. The Anesthesia Eighth edition. New York: Elsevier; 2012.  In press.

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