The MGH hosts the nation’s largest hospital-based neuroscience research program, with over 100 principal investigators, and as many junior faculty and fellows. It is situated within the broader MGH research enterprise, which ranks first in the U.S. in funding from the National Institutes of Health.
The MGH Neurology Department’s fundamental research strategy is to focus resources simultaneously on all phases of the discovery continuum – from basic research in the genetic and biochemical basis of brain function, and translational studies that link lab findings with potential drug therapies, to clinical trials that test the safety and effectiveness of new treatments.
Using the latest technologies in genetics, imaging, molecular biology, cell biology, electrophysiology, microscopy, neuroanatomy, drug discovery and drug testing, MGH investigators and clinicians are dedicated to scientific discovery that will change patients’ lives.
Because of the enormity of the challenge to make further breakthroughs possible, the Department of Neurology’s research effort is organized into institutes on both the MGH main campus and the Charlestown campus, including:
These institutes and centers bring independent laboratories together to encourage investigators from different disciplines to collaborate, strategize and share technology to minimize the time it takes to progress from basic research to treatments, therapies and drug trials. This approach fosters a vibrant collegial environment that increases prospects for near-term breakthroughs.
In addition, basic and translational research is closely connected to clinical research conducted at the Neurology Clinical Trials Unit, and in every subspecialty clinic in the department.
Our faculty is world renowned, staffed with outstanding neuroscientists and physician-scientists who also treat patients in both outpatient and inpatient settings at the MGH.
All faculty members hold appointments at Harvard Medical School and are invested in training the next generation of neurologists and neuroscientists. Our faculty teach courses, supervise residents in the hospital, train graduate students, and mentor post-doctoral research fellows associated with Harvard Medical School.
These Neurology department faculty profiles contain research summaries and related information such as disease interests, publications and affiliations.
Dr. Young is a world-renowned expert in Huntington's and Parkinson's diseases. She and her late husband (John B. Penney, Jr.) provided the most widely cited model of basal ganglia function. The model has provided the springboard for testing novel interventions in Huntington's and Parkinson's diseases and related disorders. She has spearheaded comprehensive drug discovery efforts at the MassGeneral Institute for Neurodegenerative Disease, which has been successful in identifying drug targets for Parkinson's, Huntington's and other neurodegenerative diseases. Dr. Young's laboratory is examining the role of the protein alpha-synuclein, which plays a key role in the death of dopamine-producing brain cells in the Parkinson's disease and other diseases with similar symptoms.
Links to researcher profiles
|Mark W. Albers, MD, PhD||Fred H. Hochberg, MD|
|Hakan Ay, MD||Leigh R. Hochberg, MD, PhD|
|Brian J. Bacskai, PhD||Bradly Hyman, MD, PhD|
|Oksana Berezovska, PhD||Aleksey Kazantsev, PhD|
|Lars Bertram, MD||Kimberly Kegel, PhD|
|Pradeep G. Bhide, PhD||Raymond J. Kelleher III, MD, PhD|
|Xandra O. Breakefield, PhD||Dora M. Kovacs, PhD|
|Ippolita Cantuti-Castelvetri, PhD||Dimitri Krainc, MD, PhD|
|David Caplan, MD, PhD||Airong Li, MD, DPhil|
|Sydney S. Cash, MD, PhD||Joseph J. Locascio, PhD|
|Jang-Ho Cha, MD, PhD||Pamela J. McLean, PhD|
|Timothy W. Clark MSc||Robert D. Moir, PhD|
|Merit E. Cudkowicz, MD, MSc||Anne Louise Oaklander MD, PhD|
|William S. David, MD, PhD||Scott R. Plotkin, MD, PhD|
|Bradford C. Dickerson, MD||Vijaya Ramesh, Ph.D.|
|Marian DiFiglia, PhD||Ghazaleh Sadri-Vakili, MS, PhD|
|Anthone W. Dunah, PhD||Clemens R. Scherzer, MD|
|Volodymyr Dzhala, PhD||Michael A. Schwarzschild, MD, PhD|
|Jeffrey M. Ellenbogen, MMSc, MD||Khalid Shah, MS, PhD|
|Jonathan W. Francis, PhD||Katherine B. Sims, MD|
|Matthew P. Frosch, MD, PhD||Susan A. Slaugenhaupt, PhD|
|Karen L. Furie, MD, MPH||Tara Spires-Jones, DPhil|
|David W. Gow, PhD||Kevin J. Staley, MD|
|Steven Mark Greenberg, MD, PhD||Rudolph E. Tanzi, PhD|
|David M. Greer, MD, MA||Giuseppina Tesco, MD, PhD|
|John H. Growdon, MD||Anju Vasudevan, PhD|
|Suzanne Y. Guenette, PhD||Vanessa C. Wheeler, PhD|
|James F. Gusella, PhD||Wilma Wasco, PhD|
|Stephen J. Haggarty, PhD||Kui Xu, MD, PhD|
|Steven Hersch, MD, PhD||Anne B. Young, MD, PhD, Neurology Chief|
|Daniel B. Hoch MD, PhD|