Nutan Sharma, MD PhD
Neuroscience Center at Massachusetts General
Massachusetts General Hospital –
Charlestown, MA 02129
Dr. Sharma received both an MD and PhD from the State University of New York at Stony Brook. She completed clinical training in neurology at Yale University and further training in Movement Disorders at both Massachusetts General Hospital and Brigham and Women’s Hospital.
Our research focuses on the pathophysiology of dystonia. Laboratory efforts are focused on the role of the DYT1 mutation in the development of dopamine neurons in the midbrain, using both transgenic and knock-in DYT1 mouse models. Clinical research efforts are focused on the systematic clinical classification of dystonias and determining the underlying role of genetics in the pathophysiology of various sub-types of dystonia.
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- Sharma N, Baxter MG, Petravicz J, Bragg DC, Schienda A, Standaert DG, Breakefield XO. Impaired motor learning in mice expressing torsinA with the DYT1 dystonia mutation. J Neurosci. 2005;25(22):5351-5.
- Blood, AJ, Tuch, DS, Makris, N, Makhlouf, ML, Sudarsky, LR, Sharma, N. White matter abnormalities in dystonia normalize after botulinum toxin treatment. NeuroReport. 2006;17(12):1251-1255.
- Pisani, A, Martella, G, Tscherter, A, Bonsi, P, Sharma, N, Bernardi, G, Standaert, DG. Altered responses to dopaminergic D2 receptor activation and N-type calcium currents in striatal cholinergic interneurons in a mouse model of DYT1 dystonia . Neurobiology of Disease. 2006;24(2):318-325.
- Balcioglu, A, Kim MO, Sharma N, Cha JH, Breakefield XO, Standaert D . Dopamine release is impaired in a mouse model of DYT1 dystonia . Journal Of Neurochemistry. 2007;102(3):783-788.
- Sciamanna G, Bonsi P, Tassone A, Cuomo D, Tscherter A, Viscomi MT, Martella G, Sharma N, Bernardi G, Standaert DG, Pisani A Impaired striatal D2 receptor function leads to enhanced GABA transmission in a mouse model of DYT1 dystonia. Neurobiol Dis. 2009 Apr;34(1):133-45
- Bragg DC, Armata IA, Nery FC, Breakefield XO, Sharma N. Molecular pathways in dystonia. Neurobiol Dis. 2010 Dec 4. [Epub ahead of print]