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Jack T. Rogers, Ph.D.
Neuroscience Center at Massachusetts General Hospital


Massachusetts General Hospital – East
Building 114
16th Street
Charlestown, MA 02129
Telephone: 617-726-8838

Biography and Research Program

Jack Rogers, PhD. is a Leading authority on the role that RNA in the maintenance of iron homeostasis related to disease processes in the blood (anemia) and in Alzheimer’s disease, and more recently in the etiology of Parkinson’s disease. Director of the Neurochemistry Laboratory in the Psychiatry Department at Massachusetts General Hospital and an Associate Professor at the Harvard Medical School, Jack has an extensive track record in established scientific journals (J. Biol. Chem. and PNAS). His numerous articles and peer review publications are on the subjects of iron metabolism, and translational control related disease progression, now including Parkinson’s disease. Recently he has focused energy towards developing a program in drug discovery to find therapies for people with neurodegenerative diseases. An integrative program was instigated to use RNA based therapeutic strategies to ameliorate the progression of Alzheimer’s disease (2002-2007), and now for Parkinson’s disease in partnership with the Michael J-Fox Foundation (2008). He is an excellent mentor and of postdoctoral fellows with a creative approach to gene base therapies and basic science, he serves on several scientific advisory Boards. He and his family live in Arlington, Massachusetts.

External Link
The Michael J. Fox Foundation for Parkinson's Research

Selected Recent Publications
Click here to access a full PubMed search on Dr. Rogers

  • Rogers JT, Bush AI, Cho HH, Smith DH, Thomson AM, Friedlich AL, Lahiri DK, Leedman PJ, Huang X, Cahill CM. Iron and the translation of the APP and ferritin mRNAs: Riboregulation against neural oxidative damage in AD. Biochem Soc Trans. 2008, 36:1282-7.
  • Cahill, CM., Rogers, JT. Interleukin-1beta induction of Interleukin-6 is mediated by a novel PI3 kinase IKK. AKT/IKK pathway targeting AP-1. J. Biol. Chem. 2008 VOL. 283, NO. 38, pp. 25900–25912.
  • Qureshi, M., Brown Jr, RH., Rogers, JT., Cudkowicz, ME. A study of serum ferritin as a risk factor for amyotrophic lateral sclerosis. The Open Neurology Journal. 2008; 2: 51-54.
  • Kong W, Mou X, Liu Q, Chen Z, Vanderburg CR, Rogers JT, Huang X Mol Neurodegn. 2009: 28;4(1):5.
  • Cahill, CM., Lahiri, DK., Huang, X., Rogers, JT. The amyloid precursor protein (APP) and alpha synuclein translation, Implications for iron and inflammation in neurodegenerative diseases. Biochem Biophysics Acta, 2009:1790. 615-628

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