Neuroscience Center at Massachusetts General
Massachusetts General Hospital –
Charlestown, MA 02129
Dr. Moskowitz received his M.D. from Tufts University, Boston. Following
postdoctoral training at the Massachusetts Institute of Technology,
Cambridge, he came to the MGH in 1975 where he is currently professor
The Moskowitz laboratory has a long-standing
interest in mechanisms regulating cerebral blood vessel function with
a particular focus on interactions between neurons, glial and vascular
cells. Such studies are relevant to the pathophysiology of stroke, migraine,
and traumatic brain injury. In the past, his laboratory discovered the
sensory innervation to the Circle of Willis and the triggering of the
trigeminovascular innervation by intense neuronal and glial activity.
His laboratory also was the first to identify the
neuronal 5HT receptor subtypes for abortive anti-migraine drugs. More
recent research projects relate to matrix metalloproteases (MMPs) and
their upregulation on vascular permeability following cortical spreading
depression. In addition to MMPs, his laboratory has a long-standing
interest in tissue mediators of brain injury including nitric oxide
and has studied its Janus effect on vascular function and cell death.
For this project, his laboratory developed unique
expertise in physiological monitoring in genetically engineered mice
including techniques to evaluate cerebrovascular physiology in fully
instrumented animals. His laboratory used these methods to examine the
relevance of specific cell types and pathways important in cerebral
ischemia such as the contribution of the endothelium and brain parenchyma
to stroke protection by NO and the statins. Experiments over the past
decade have examined caspases as mediators of cell demise and the role
of death receptors in ischemic brain injury.
His laboratory is now examining the molecular consequences
of cortical spreading depression as a potential mechanism to understand
drug activity and as mechanism linking the pathophysiologic relationship
between migraine and stroke.
here to access a full PubMed search on Dr. Moskowitz
- Moskowitz MA, Lo EH. Neurogenesis and apoptotic
cell death. Stroke 2003;34:324-326.
- Chiarugi A, Moskowitz MA. Poly(ADP-ribose) polymerase-1
activity promotes NF-kB-driven transcription and microglial activation:
implication for neurodegenerative disorders. J Neurochem. 2003;85:306-317.
- Atochin DN, Clark J, Demchenko IT, Moskowitz MA,
and Huang PL. Rapid cerebral ischemic preconditioning in mice deficient
in endothelial and neuronal nitric oxide synthases. Stroke 2003;34:1299-1303.
- Teramoto T, Qiu J, Plumier JC, Moskowitz MA. EGF
amplifies the replacement of parvalbumin-expressing striatal interneurons
after ischemia. J Clin Invest. 2003;111:1125-1132.
- Lo EH, Dalkara T, Moskowitz MA. Mechanisms, challenges
and opportunities in stroke. Nat Rev Neurosci. 2003;4:399-414.
- Finklestein SP, Fisher M, Furland AJ, et.al. Recommendations for
standards regarding preclinical neuroprotective and restorative drug
development. Special Report. Stroke 1999;30:2752-2758.
- Yoshimura S, Teramoto T, Whalen MJ, Irizarry MC, Takagi Y, Qiu J,
Harada J, Waeber C, Breakefield XO, Moskowitz MA.
FGF-2 regulates neurogenesis and degeneration in the dentate gyrus
after traumatic brain injury in mice. J Clin Invest. 2003;112:1202-1210.
- Wada K, Sugimori H, Bhide PG, Moskowitz MA, Finklestein
SP. Effect of basic fibroblast growth factor treatment on brain progenitor
cells after permanent focal ischemia in rats. Stroke 2003;34:2722-2728.
- Frenkel D, Huang Z, Maron R, Koldzic DN, Hancock WW, Moskowitz
MA, Weiner HL. Nasal vaccination with myelin oligodendrocyte
glycoprotein reduces stroke size by inducing IL-10-producing CD4+T
cells. J Immunol. 2003;171: 6549-6555.
- Lo EH, Broderick JP, Moskowitz MA. Advances in
stroke 2003: tPA and proteolysis in the neurovascular unit. Stroke
Harada J, Foley M, Moskowitz MA, Waeber C. Sphingosine-1-phosphate
induces proliferation and morphological changes of neural progenitor
cells. J Neurochem. 2004;88:1026-1039.
- Plesnila N, Zhu C, Culmsee C, GrÖger M, Moskowitz MA,
Blomgren K. Nuclear translocation of apoptosis-inducing factor after
focal cerebral ischemia. J Cereb Blood Flow Metab. 2004;24:458-466.
- Qiu J, Takagi Y, Harada J, Rodriques N, Moskowitz MA,
Scadden DT, Cheng T. Regenerative response in ischemic brain restricted
by p21cip1/waf1. J Exp Med. 2004;199:937-945