H. Lo, Ph.D.
Neuroscience Center at Massachusetts General
Massachusetts General Hospital –
Charlestown, MA 02129
Dr. Lo received his B.S. in electrical engineering from Yale, his Ph.D. in biophysics from the University of California Berkeley, and completed his postdoctoral training in neuroscience at Stanford. He moved to MGH in 1991, and is currently the Head of the Neuroprotection Research Lab, and Professor of Neuroscience in Harvard Medical School.
The MGH Neuroprotection Research Lab uses in vitro and in vivo models to investigate the molecular mechanisms that underlie cell death after stroke and trauma, and assess novel strategies for neuroprotection. Our tools comprise a combination of in vivo imaging, pharmacology, and molecular cell biology. We seek to understand how perturbations in cell-cell and cell-matrix signaling mediate neurovascular dysfunction in brain injury and neurodegeneration. As part of the HMS Program in Neuroscience, our lab welcomes PhD candidates who are interested in the neurobiology of disease.
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Wang X, Lee SR, Arai K, Lee SR, Tsuji K, Rebeck GW, Lo EH._Lipoprotein
receptor-mediated induction of matrix metalloproteinase by_tissue
plasminogen activator. Nature Med 9:1313-1317, 2003.
2. Lo EH, Dalkara T, Moskowitz MA. Mechanisms, challenges and_opportunities in stroke. Nat Rev Neurosci 4:399-415, 2003.
3. Lee SR, Tsuji K, Lee SR, Lo EH. Role of matrix
metalloproteinases in_delayed neuronal damage after transient global
cerebral ischemia. J_Neurosci 24:671-678, 2004.
4. van Leyen K, Siddiq A, Ratan RR, Lo EH. Proteasome inhibition
protects HT22 neuronal cells from oxidative glutamate toxicity. J
Neurochem. 2005 Feb;92(4):824-30.
5. Lee SR, Kim HY, Rogowska J, Zhao BQ, Bhide P, Parent JM, Lo
EH. Involvement of matrix metalloproteinase in neuroblast cell
migration from the subventricular zone after stroke. J Neurosci
6: Zhao BQ, Wang S, Kim HY, Storrie H, Rosen BR, Mooney DJ, Wang
X, Lo EH. Role of matrix metalloproteinases in delayed cortical
responses after stroke. Nature Med 12:441-445, 2006.
7. Lo EH. A new penumbra: transitioning from injury into repair after stroke. Nature Med 2008; 14:497-500.
8. Guo S, Kim WJ, Lok J, Lee S, Besancon E, Luo B, Stins M, Wang X, Dedhar S, Lo EH. Neuroprotection via matrix-trophic coupling between cerebral endothelial cells and neurons. Proc Natl Acad Sci USA 2008; 105:7582-7587.
9. Rosell A, Arai K, Lok J, He T, Guo S, Navarro M, Montaner J, Katusic Z, Lo EH. Interleukin-1-beta augments angiogenic responses of murine endothelial progenitor cells in vitro. J Cereb Blood Flow Metab 2009; 29:933-943.
10. Arai K, Lo EH. An oligovascular niche: cerebral endothelial cells promote survival and proliferation of oligodendrocyte precursor cells. J Neurosci 2009; 29:4351-4355.