Date Prepared:

12/19/08

Name:

Hai Ning Shi, DVM, PhD

Office Address:

Mucosal Immunology Laboratory
Massachusetts General Hospital and Harvard Medical School
114 16th Street 114-3503
Charlestown, MA. 02129

Work Phone:

(617) 726-4173

Work FAX:

(617) 726-4172

Work E-Mail:

shiha@helix.mgh.harvard.edu

1982

D.V.M.

Veterinary Medicine

Qinghai University School of Animal Science and Veterinary Medicine. Qinghai, P. R. China

1996

Ph.D.

Parasitology/Immunology

McGill University. Montreal, Canada

A. Positions and Honors.

Positions and Employment

1990-1991

Visiting Scientist

Institute of Parasitology, McGill University, Canada

1991-1996

Research Assistant and PhD student

Institute of Parasitology, McGill University, Canada.

1996-1999

Postdoctoral Fellow

Mucosal Immunology Lab
Pediatric Gastroenterology and Nutrition
Massachusetts General Hospital & Harvard Medical School

1999

Instructor in Pediatrics

Harvard Medical School

Assistant Immunologist

Massachusetts General Hospital

2002

Assistant Professor of Pediatrics

Harvard Medical School

Other Experience and Professional Memberships

1998

American Association of Immunologists

2001

American Gastroenterology Association

2005

American Society for Microbiology

2005

Society for Mucosal Immunology

Awards and Honors

1990-1992

Differential Fee Waiver Awards
for International Students

McGill University, Canada.

1992

Summer Bursary

McGill University.

1992

Graduate Student Travel Award

Canadian Society of Zoology.

1993

Lynden Laird Lyster Memorial
Award in Parasitology

McGill University.

1994

Wyeth Graduate Student Award

The Canadian Society of Nutritional Sciences and The Canadian Federation of Biological Societies.

1998-2001

Research Fellowship Award

Crohn’s & Colitis Foundation of America (CCFA)

2001-2002

Career Development Award

CCFA.

2003

First Award

CCFA. Relinquished when KO1 was awarded.

2003-

KO1 Award

NIH.

B. Selected peer-reviewed publications (in chronological order)

1.

Hai Ning Shi, Marilyn E. Scott, Mary M. Stevenson, and Kristine G. Koski. Zinc deficiency impairs T cell function in mice with primary infection of Heligmosomoides polygyrus (Nematoda). Parasite Immunology. 1994; 16: 339-350.

2.

Hai Ning Shi, Marilyn E. Scott, Kristine G. Koski, Marjolaine Bouley and Mary M. Stevenson. Energy restriction and severe zinc deficiency influence development, survival and reproduction of Heligmosomoides polygyrus (Nematoda) during primary and challenge infections in mice. Parasitology. 1995; 110: 599-609.

3.

Hai Ning Shi, Kristine G. Koski, Mary M. Stevenson and Marilyn E. Scott. Zinc deficiency and energy restriction modify immune responses in mice during both primary and challenge infection with Heligmosomoides polygyrus (Nematoda). Parasite Immunology. 1997;19: 363-373.

4.

Hai Ning Shi, Marilyn E. Scott, Kristine G. Koski and Mary M. Stevenson. Zinc deficiency and concurrent energy restriction reduce the functions of murine T cells and antigen-presenting cells during a gastrointestinal nematode infection. Journal of Nutrition. 1997; 128: 20-27.

5.

Hai Ning Shi, Christian Ingui, Ingrid Dodge and Cathryn Nagler-Anderson. A helminth induced mucosal Th2 response alters non-responsiveness to oral administration of a soluble antigen. Journal of Immunology. 1998, 160: 2449-2455.

6.

Hai Ning Shi, Michael J. Grusby and Cathryn Nagler-Anderson. Orally induced peripheral nonresponsiveness is maintained in the absence of functional Th1 or Th2 cells. Journal of Immunology. 1999, 162; 5143-5148.

7.

Hai Ning Shi and Cathryn Nagler-Anderson. Mucosal T cell responses to enteric infection. Current Opinion in Gastroenterology. 1999; 15: 529-533.

8.

James G. Fox, Paul Beck, Charles A Dangler, Mark T. Whary, Timothy C. Wang, Hai Ning Shi and Cathryn Nagler-Anderson. Concurrent enteric infection modulates inflammation, gastric immune responses, and reduces helicobacter-induced gastric atrophy. Nature Medicine. 2000; 6 (45): 536-542.

9.

Hai Ning Shi, Hao Yuan Liu and Cathryn Nagler-Anderson. Enteric infection acts as an adjuvant for the response to a model food antigen. Journal of Immunology. 2000, 165: 6174-6182.

10.

Cathryn Nagler- Anderson and Hai Ning Shi. Peripheral Nonresponsiveness to orally administered soluble protein antigens. Critical Reviews in Immunology. 2001. 21:121-131.

11.

Bashir MEH, Andersen P., Fuss I.J., Shi H.N. and Nagler-Anderson C. An enteric helminth infection protects against allergic response to dietary antigen. Journal of Immunology 2002, 169: 3284-3292.

12.

Hai Ning Shi and W. Allan Walker. T helper cell subclasses and clinical disease states. Current Opinion in Gastroenterology. 2002, 18 (6): 711-716.

13.

Bashir MEH, Louie S., Shi H.N. and Nagler-Anderson C. TLR4 signaling by intestinal microbes influences susceptibility to food allergy. 2004. Journal of Immunology. 2004. 172(11):6978-87.

14.

Shi HN, Walker A. Bacterial colonization and the development of intestinal defences. Can J Gastroenterol. 2004 Aug; 18(8):493-500

15.

Hai Ning Shi and W. Allan Walker. Bacterial colonization in the developing gastrointestinal tract: Role in the pathogensis of intestinal diseases. Bioscience Microflora. 2004, 23(2):55-65.

16.

Moran ST, Cariappa A, Liu H, Boboila C, Shi HN, Holland PM, Peschon JJ, Pillai S. Protein kinase C-associated kinase is not required for the development of peripheral B lymphocyte populations. Mol Immunol. 2005. Oct.24.

17.

Annaiah Cariappa, Irina B. Mazo, Catharine Chase, Hai Ning Shi, Haoyuan Liu, Qian Li, Harris Rose, Harry Leung, Bobby J. Cherayil, Paul Russell, Ulrich von Andrian, and Shiv Pillai. Perisinusoidal B Cells in the Bone Marrow Participate in T-Independent Responses to Blood-Borne Microbes. Immunity. 2005. 23 (4): 397-407.

18.

Chien-Chang Chen, Hai Ning Shi and Allan Walker. Precolonization with probiotics Lactobacillus acidophilus NCFM at early life attenuates Citrobacter rodentium induced colitis in mice. Pediatric Research. 2005. 58 (6): 1185-1191.

19.

Chien-Chang Chen, Steve Louie, Beth McCormick, Allan Walker and Hai Ning Shi. Concurrent infection of an intestinal helminth parasite impairs host resistance to enteric Citrobacter rodentium and enhances Citrobacter-induced colitis in mice. Infection and Immunity. 2005. 73: 5468-5481.

20.

Jianmin Liu, Sherry L. Ball, Yuan Yang, Pinchao Mei, Lei Zhang, Hai Ning Shi, Henry J. Kaminski, Vance P. Lemmon and Huaiyu Hu. A genetic model for muscle-eye-brain disease in mice lacking protein O-mannose 1,2-N-acetylglucosaminyltransferase (POMGnT1). Mechanisms of Development. 2006. Feb.

21.

Tor C. Savidge, Paul G. Newman, Wei-Hua Pan, Mei-Qian Weng, Hai Ning Shi, Beth A. McCormick, Andrea Quaroni, W. Allan Walker. Lipopolysaccharide-induced human enterocyte tolerance to cytokine-mediated interleukin-8 production may occur independently of TLR-4/MD-2 signalling. Pediatric Research. 2006. 59 (1): 89-95.

22.

Chien-Chang Chen, Steve Louie, Beth McCormick, Allan Walker and Hai Ning Shi. Helminth primed dendritic cells alter the host response to enteric bacterial infection. The Journal of Immunology. 2006. 176: 472-483.

23.

Wall, D.M, Nadeau, W.J, Pazos, M.A, Shi, H.N, Galyov, E.E, McCormick, B.A. Identification of the Salmonella enterica serotype Typhimurium SipA domain responsible for inducing neutrophil recruitment across the intestinal epithelium. Cellular Microbiology. 2007. 9(9): 2299-2313.

24.

Harrington, Lynne; Srikanth, Chittur; Antony, Reuben; Shi, Hai Ning; Cherayil, Bobby. A role for natural killer cells in intestinal inflammation caused by infection with Salmonella enterica serovar Typhimurium. FEMS Immunology & Medical Microbiology. 2007. 51: 372–380.

25.

Annaiah Cariappa, Cristian Boboila, Stewart T. Moran, Haoyuan Liu, Hai Ning Shi, and Shiv Pillai. The Recirculating B Cell Pool Contains Two Functionally Distinct, Long-Lived, Posttransitional, Follicular B Cell Populations. The Journal of Immunology. 2007. 179(4): 2270-2281.

26.

Meiqian Weng, Deke Huntley, I-Fei Huang, Ondulla Foye-Jackson, Lijian Wang, Aliese Sarkissian, Qingping Zhou, W. Allan Walker, Bobby J. Cherayil and Hai Ning Shi. Alternatively activated macrophages in intestinal helminth infection: effects on concurrent bacterial colitis. The Journal of Immunology. 2007. 179:4721-4731.

27.

Hai Ning Shi, W. Allan Walker. The role of TIM-4 in food allergy. Gastroenterology. 2007. 133: 1723-1726.

28.

Lynne Harrington, Chittur V. Srikanth, Reuben Antony, Sue J. Rhee, Andrew L. Mellor, Hai Ning Shi, and Bobby J. Cherayil. 2008. Deficiency of Indoleamine 2,3-Dioxygenase Enhances Commensal-Induced Antibody Responses and Protects against Citrobacter rodentium-Induced Colitis. Infection and Immunity. Vol. 76: 3045-3053.

29.

Yasuyo Shimomura, Atsuhiro Ogawa, Mayumi Kawada, Ken Sugimoto, Emiko Mizoguchi, Hai-Ning Shi, Shiv Pillai, Atul K. Bhan, and Atsushi Mizoguchi. 2008. A unique B2 B cell subset in the intestine. The Journal of Experimental Medicine, Vol. 205, No. 6, 1343-1355.

30.

Lijian Wang, Erin E. Johnson, Hai Ning Shi, W. Allan Walker, Marianne Wessling-Resnick, Bobby J. Cherayil. 2008. Attenuated inflammatory responses in hemochromatosis reveal a role for iron in the regulation of macrophage cytokine translation. The Journal of Immunology. 2008. 181 (4) 2723-2731.

31.

Michael Pazos, Dario Siccardi, Karen L. Mumy, Jeffrey D. Bien, Steve Louie, Hai Ning Shi, Karsten Gronert, Randall J. Mrsny, and Beth A. McCormick. Multi-Drug Resistance Transporter 2 Regulates Mucosal Inflammation by Facilitating the Synthesis of Hepoxilin A3. The Journal of Immunology. 2008. In press

32.

Lijian Wang, Yue Cao and Hai Ning Shi. Helminth infections and intestinal inflammation. World J Gastroenterol. 2008 Sep 7;14(33):5125-32

33.

Annaiah Cariappa, Hiromu Takematsu, Haoyuan Liu, Sandra Diaz, Khaleda Haider, Cristian Boboila, Geetika Kalloo, Michelle Connole, Hai Ning Shi, Nissi Varki, Ajit Varki, and Shiv Pillai. B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase. The Journal of Experimental Medicine. 2008. In Press

C. Research Support

Current Research Support

R21 DK074727

Hai Ning Shi (P.I.)

10/1/07-9/30/09

NIH/NIDDK

Immunomodulation of bacteria-associated colitis by helminth infection
The goal of this project is to characterize the helminth-induced phenotypic and functional alterations in the subset of dendritic cells (DCs) and to elucidate the role of helminth-primed DCs and subset of DCs in the alterations of the host defense against enteric bacteria and the exacerbation of bacteria-associated intestinal inflammation.

Completed Research Support

KO1 DK59996

Hai Ning Shi (P.I.)

7/1/2003-6/30/06

NIH/NIDDK.

Triggering intestinal inflammation
The specific aims focus on epithelial cell-commensal bacterial interaction in intestinal inflammation and the role and mechanisms of bacterial products and components in the induction and regulation of intestinal inflammatory response.

Pilot Feasibility Study

Hai Ning Shi (P.I.)

2001

NIH/MGH Center for the Study of Inflammatory Bowel Disease.

Triggering intestinal inflammation
This study examined the role of bacterial antigen in the induction of immune and inflammatory response in mouse intestine.

Career Development Award

Hai Ning Shi (P.I.)

1/1/2001-12/31/2002

Crohn’s and Colitis Foundation of America.

Triggering intestinal inflammation
Using a bacterial antigen delivery system and adoptive transfer model to examine the triggering role of intestinal bacterial antigen in the induction of immune and inflammatory response in the intestine; To Examine the role of IL-10 and TLR4 in the development of intestinal inflammation in mice.

Child Health Research Grant

Hai Ning Shi (P.I.)

1/1/2001-12/31/2003

Charles H. Hood Foundation.

The induction of intestinal inflammation: Role of luminal bacterial antigen
This project is to study the role of bacterial antigen and superantigen in the induction of intestinal inflammation; to study the therapeutic role of probiotics in suppression of intestinal inflammation induced by bacterial antigen; and to examine the regulatory role of IL-10 in this model system.

First Award

Hai Ning Shi (P.I.)

1/1/03/6/30/03

Crohn’s & Colitis Foundation of America

Investigation of epithelial cell-commensal bacterial interaction in intestinal inflammation
This study examines the role and mechanisms of bacterial products and components in the induction and regulation of intestinal inflammatory response.