Curriculum Vita

Hai Ning Shi, DVM, PhD
Associate Professor of Pediatrics

Selected publications (last 5 years)

1. Meiqian Weng, Deke Huntley, I-Fei Huang, Ondulla Foye-Jackson, Lijian Wang, Aliese Sarkissian, Qingping Zhou, W. Allan Walker, Bobby J. Cherayil and Hai Ning Shi. (2007). Alternatively activated macrophages in intestinal helminth infection: effects on concurrent bacterial colitis. The Journal of Immunology, 179:4721-4731
2. Hai Ning Shi and Walker A Walker. The role of TIM-4 in food allergy. Gastroenterology. 2007. 133: 1723-1726.
3. Wall, D.M, Nadeau, W.J, Pazos, M.A, Shi, H.N, Galyov, E.E, McCormick, B.A. Identification of the Salmonella enterica serotype Typhimurium SipA domain responsible for inducing neutrophil recruitment across the intestinal epithelium. Cellular Microbiology. 2007. 9(9): 2299-2313.
4. Harrington, Lynne; Srikanth, Chittur; Antony, Reuben; Shi, Hai Ning; Cherayil, Bobby. A role for natural killer cells in intestinal inflammation caused by infection with Salmonella enterica serovar Typhimurium. FEMS Immunol Med. Microbiol. 2007. 51: 372–380
5. Annaiah Cariappa, Cristian Boboila, Stewart T. Moran, Haoyuan Liu, Hai Ning Shi, and Shiv Pillai. The Recirculating B Cell Pool Contains Two Functionally Distinct, Long-Lived, Posttransitional, Follicular B Cell Populations. The Journal of Immunology. 2007. 179(4): 2270-2281.
6. Lynne Harrington, Chittur V. Srikanth, Reuben Antony, Sue J. Rhee, Andrew L. Mellor, Hai Ning Shi, and Bobby J. Cherayil. Deficiency of Indoleamine 2,3-Dioxygenase Enhances Commensal-Induced Antibody Responses and Protects against Citrobacter rodentium-Induced Colitis. Infection and Immunity. 2008. Vol. 76: 3045-3053. PMCID: PMC2446721
7. Yasuyo Shimomura, Atsuhiro Ogawa, Mayumi Kawada, Ken Sugimoto, Emiko Mizoguchi, Hai-Ning Shi, Shiv Pillai, Atul K. Bhan, and Atsushi Mizoguchi. 2008. A unique B2 B cell subset in the intestine. The Journal of Experimental Medicine, Vol. 205, No. 6, 1343-1355. PMCID: PMC2413032
8. Lijian Wang, Erin E. Johnson, Hai Ning Shi, W. Allan Walker, Marianne Wessling-Resnick, Bobby J. Cherayil. Attenuated inflammatory responses in hemochromatosis reveal a role for iron in the regulation of macrophage cytokine translation. The Journal of Immunology. 2008. 181 (4) 2723-2731. PMCID: PMC2561261
9. Michael Pazos, Dario Siccardi, Karen L. Mumy, Jeffrey D. Bien, Steve Louie, Hai Ning Shi, Karsten Gronert, Randall J. Mrsny, and Beth A. McCormick. Multi-Drug Resistance Transporter 2 Regulates Mucosal Inflammation by Facilitating the Synthesis of Hepoxilin A3. The Journal of Immunology. 2008. 181(11):8044-52. PMCID: PMC2596662
10. Lijian Wang, Yue Cao and Hai Ning Shi. Helminth infections and intestinal inflammation. World J Gastroenterol. 2008 Sep 7;14(33):5125-32. PMCID: PMC2744001
11. Annaiah Cariappa, Hiromu Takematsu, Haoyuan Liu, Sandra Diaz, Khaleda Haider, Cristian Boboila, Geetika Kalloo, Michelle Connole, Hai Ning Shi, Nissi Varki, Ajit Varki, and Shiv Pillai. B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase. The Journal of Experimental Medicine. 2009.16;206(1):125-38
12. Conroy ME, Shi HN, Walker WA. The long-term health effects of neonatal microbial flora. Curr Opin Allergy Clin Immunol. 2009, 9(3):197-201.
13. Kaplan JL, Shi HN, Walker WA. The role of microbes in developmental immunologic programming. Pediatric Research. 2011. 69(6):465-72.
14. Chen CC, Chiu CH, Lin TY, Shi HN, Walker WA. Effect of probiotics Lactobacillus acidophilus on Citrobacter rodentium colitis: the role of dendritic cells. Pediatr Res. 2009 Feb;65(2):169-75
15. Wang L, Harrington L, Trebicka E, Shi HN, Kagan JC, Hong CC, Lin HY, Babitt JL, Cherayil BJ. Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice. J Clin Invest. 2009. 119(11):3322-8. PMCID: PMC2769199
16. C.V. Srikanth, Daniel M. Wall, Ana Maldonado-Contreras, Hai Ning Shi, Daoguo Zhou, Zachary Demma, Karen L. Mumy, and Beth A. McCormick. Salmonella pathogenesis and processing of secreted effectors by caspase-3. Science. 2010. 330(6002):390-3.
17. Kaplan JL, Shi HN, Walker WA. The role of microbes in developmental immunologic programming. Pediatric Research. 2011. 69(6):465-72.
18. Chien-Chang Chen, Wei-Chuan Lin, Man-Shan Kong, Hai Ning Shi, W. Allan Walker, Chun-Yen Lin, Ching-Tai Huang, Yung-Chang Lin, Shih-Ming Jung, Tzou-Yien Lin. Oral inoculation of probiotics Lactobacillus acidophilus NCFM suppresses tumor growth both in segmental orthotopic colon cancer and extraintestinal tissue. 2011. British Journal of Nutrition. 2011 Sep 30:1-12. PMID: 21992995
19. Chien-wen Su, Yue Cao, Jess Kaplan, Mei Zhang, Michelle Conroy, W Allan Walker, and Hai Ning Shi. Duodenal helminth infection alters barrier function of the colonic epithelium via adaptive immune activation. Infection and Immunity. 2011. June 79(6): 2285-94. PMC3125859
20. Atsushi Nishida, Cindy W. Lau, Mei Zhang, Akira Andoh, Hai Ning Shi, Emiko Mizoguchi, and Atsushi Mizoguchi. The Membrane-Bound Mucin Muc1 Regulates Th17-Cell Responses and Colitis in Mice . Gastroenterology, 2012 142(4):865-874 PMID: 22202458.
21. Zhang Y, Xu Z, Wang H, Dong Y, Shi HN, Culley DJ, Crosby G, Marcantonio ER, Tanzi RE, Xie Z. Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory. Ann Neurol. 2012 Jan 19. doi: 10.1002/ana.23536. PMID: 22368036.
22. Foye OT, Huang IF, Chiou CC, Allan Walker W, Shi HN. Early Administration of Probiotic Lactobacillus acidophilus and/or Prebiotic Inulin Attenuates Pathogen-mediated Intestinal Inflammation and Smad 7 Cell Signaling. FEMS Immunol Med Microbiol. 2012 65(3):467-80. PMID: 22524476
23. Chien-wen Su1, Yue Cao1, Mei Zhang, Jess Kaplan, Libo Su, Ying Fu, W. Allan Walker, Ramnik Xavier, Bobby J. Cherayil and Hai Ning Shi (1 These authors contributed equally to this work). Helminth infection impairs autophagy-mediated killing of bacterial enteropathogens by macrophages. The Journal of Immunology. 2012, 189(3):1459-66. PMID: 22732589

Research Support

Current Research Support

R01 NIH/NIDDK DK082427       05/01/10-04/30/15
Immunomodulatory effects of helminthes on mucosal immunity
The studies proposed in this R01 project will determine the immuomodulatory role of intestinal helminth parasites in bacteria-associated and T cell-mediated intestinal inflammation.
Role: PI

P30 NIH/NIDDK DK40561 (Walker)      07/01/12-6/30/17
Nutrition Obesity Research Center at Harvard
Specific aims of project: The major specific aims are: 1) to provide research in basic areas of biology relevant to problems in clinical nutrition; 2) to promote the study of clinical nutrition and application of knowledge  derived there from within the HMS, MIT and HSHP community; 3) to promote interactions among scientists and clinical investigators to show relevance to advancing the science of clinical nutrition; and 4) to attract "basic" investigators into the domain of clinical nutrition to promote an environment and mechanism to develop new investigator-initiated research.
Role: Director Cell Biology Core (Shi)

R01 AI081807 (Mizoguchi)      12/01/10-11/30/15
NIH/NIAID
Inducible Regulatory B cells BREG
The major goal of this project is to identify the differentiation pathway of inducible regulatory B cells with immune regulatory ability independent of immunoglobulins. 

Nestec Ltd (Shi)     01/01/11-12/31/13
Nestec Research Grant
In this proposed investigation, utilizing a recently established novel murine model, we seek to understand how early immune development is influenced by maternal factors.  
Role: PI

Completed Research Support
R21  DK074727  Hai Ning Shi (P.I.)      10/1/07-8/31/10
Immunomodulation of bacteria-associated colitis by helminth infection
NIH/NIDDK
The goal of this project is to characterize the helminth-induced phenotypic and functional alterations in the subset of dendritic cells (DCs) and to elucidate the role of helminth-primed DCs and subset of DCs in the alterations of the host defense against enteric bacteria and the exacerbation of bacteria-associated intestinal inflammation.
Role: PI

KO1 DK59996  Hai Ning Shi (P.I.)        7/1/2003-6/30/06
NIH/NIDDK.
Triggering intestinal inflammation
The specific aims focus on epithelial cell-commensal bacterial interaction in intestinal inflammation and the role and mechanisms of bacterial products and components in the induction and regulation of intestinal inflammatory response.
Role: PI

he role of IL-10 and TLR4 in the development of intestinal inflammation in mice. 
Role: PI