Curriculum Vita
Hai Ning Shi, DVM, PhD
Assistant Professor of Pediatrics
  GENERAL INFORMATION
Date Prepared: October 18, 2008
Name: Hai Ning Shi
Office Address:
Mucosal Immunology Laboratory
Massachusetts General Hospital East, Room 3504
Building 114, 16th Street
Charlestown, MA 02129
Phone: (617) 726-4173
Fax: (617) 726-4172
E-mail: shiha@helix.mgh.harvard.edu
Education:
1982 D.V.M. Department of Veterinary Medicine, Qinghai University, School of Animal Science and Veterinary Medicine, China
1996 Ph.D. Institute of Parasitology, McGill University, Montreal, Canada
Postdoctoral Training:
1996-1999 Postdoctoral Fellow, Mucosal Immunology Laboratory, Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital and Harvard Medical School
Academic Appointments:
1982-1986 Research Fellow, Institute of Veterinary Medicine, Academy of Animal Science and Veterinary Medicine, Qinghai, China
1986-1989 Research Associate (Lecturer), Institute of Veterinary Medicine, Academy of Animal Science and Veterinary Medicine, Qinghai, China
1991-1996 Research Assistant & Ph.D. Student, Institute of Parasitology, McGill University, Canada
1996-1999 Postdoctoral Fellow, Mucosal Immunology Laboratory Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital & Harvard Medical School
1999-2002 Instructor in Pediatrics, Harvard Medical School
2002- Assistant Professor of Pediatrics, Harvard Medical School
Hospital or Affiliated Institution Appointments:
1999- Assistant Immunologist, Massachusetts General Hospital
Administrative Responsibilities:
2005- Mucosal Immunology Laboratory Website Management
2005- Co-Director, Immunology Core, Harvard Clinic Nutrition Research Center
2008- Director of Laboratory Radioactive Material Safety, Mucosal Immmunology Laboratory, Massachusetts General Hospital
Other Professional Positions and Major Visiting Appointments
1990-1991 Visiting Scientist, Institute of Parasitology, McGill University, Canada
Professional Societies:
1998- American Association of Immunologists
2001- American Gastroenterology Association
2005- American Society for Microbiology
2005- Society for Mucosal Immunology
Editorial Boards
2004- Ad hoc reviewer, The Journal of Immunology.
2005- Ad hoc reviewer, Infection and Immunity.
Awards and Honors:
1990 Visiting Scientist Fellowship, State Education Commission of The People's Republic of China
1990-1992 Differential Fee Waiver Awards for International Students, The Faculty of Graduate Studies and Research, McGill University, Montreal, Canada
1992 Summer Bursary, McGill University
1992 Graduate Student Travel Award, Canadian Society of Zoology
1993 Lynden Laird Lyster Memorial Award in Parasitology, McGill University
1994 Wyeth Graduate Student Award, The Canadian Society of Nutritional Sciences and The Canadian Federation of Biological Societies
1998 Research Fellowship Award, Crohn's & Colitis Foundation of America
2001 Career Development Award, Crohn’s & Colitis Foundation of America
2003- First Award, Crohn’s & Colitis Foundation of America
2003- The National Institute of Health (NIH) KO-1 Award
RESEARCH, TEACHING AND CLINICAL CONTRIBUTIONS
Narrative Report:
My research interests are focused on mucosal immunology and intestinal inflammation. Our ongoing research studies microbial pathogenesis and immune regulation of intestinal inflammation using helminth infection model. We study immunomodulatory effects of intestinal helminthes on mucosal immunity. We are particularly interested in exploring the mechanisms by which the helminth parasite modulates intestinal mucosal response to enteric bacteria and bacteria-associated and immune-mediated intestinal inflammation using helminth co-infection model system. Evidence from epidemiological studies indicates an inverse correlation between exposure to helminthes and the incidence of certain immune-mediated diseases (the hygiene hypothesis), including inflammatory bowel diseases (IBD). Helminth infection has been known to dampen Th1 reactions to other infections. Thus, due to the ability to attenuate damaging Th1 driven inflammatory responses in the host, helminthes have been proposed and tested as a therapeutic agent for the treatment of certain immune-mediated diseases, including IBD. However, recent experimental results, including our own, provide evidence to indicate that intestinal helminth infection can also exacerbate both infectious and non-infectious forms of colitis under some circumstances. A more comprehensive understanding of the mechanisms by which these parasites alter host intestinal inflammatory and immune responses may provide new information for establishing more effective and safer preventive and therapeutic approaches to the treatment of both Th1 and Th2-mediated diseases, and for the design of effective intestinal vaccines.
We also study the impact of intestinal colonization of probiotics at early life on the development and regulation of mucosal T cell responses (Th1, Th2, Th17 and Treg) and explore the mechanisms by which probiotics modulate mucosal immunity and host protection against enteric pathogens. We also explore the role of bacterial products as triggering agents to alter intestinal barrier function and mucosal immune function. Our research will provide greater insight about how intestinal microorganisms may alter the regulatory mechanisms of mucosal immunity, which may be instrumental in the establishment of effective preventive and therapeutic approaches for the treatment of immune mediated disorders.
Funding Information
1998-2001 Research Fellowship Award, Crohn's and Colitis Foundation of America. “Altered responsiveness to food proteins in the presence of mucosal infection”
1999 NIH/Clinic Nutrition Research Center at Harvard/Pilot Feasibility Project. Co-P.I.“Influence of helminth infection on food allergy”
2001 NIH/MGH Center for the Study of Inflammatory Bowel Disease Pilot Feasibility Study P.I.“ Triggering intestinal inflammation”
1/2001-12/2002 Career Development Award, Crohn’s and Colitis Foundation of America. P.I.“Triggering intestinal inflammation”
2000-2003 Hood Foundation Grant, Charles H. Hood Foundation P.I. “The induction of intestinal inflammation: Role of luminal bacterial antigen”
2003- First Award, Crohn’s & Colitis Foundation of America. P.I. “Investigation of epithelial cell-commensal bacterial interaction in intestinal inflammation”
2003 NIH/KO1 P.I. “Triggering intestinal inflammation”
2006 P. I. Massachusetts General Hospital Interim Support Fund.
2007- NIH/NIDDK. DK074727(R21), P.I., “Immunomodulation of bacteria-associated colitis by helminth infection
C. Teaching:
1. Local Contributions
2001 - Tutor, Immunology Microbiology and Infectious Disease, Harvard Medical School.
2003-2008 - Course Co-Director, Molecular Cell Biology, Pediatric GI Fellow and Student Course (a class size of 10 students).
Advisory and supervisory responsibilities:
Postdoctoral fellows, undergraduate students, and research technologists.
Postdoctoral Fellows (past):
2002-2005 Chienchang Chen, MD (Postdoctoral Research Fellow).
Current position: Assistant Professor at Chang Gung University and Chang Gung Children's Hospital, Taiwan
2002-2003 Weishu Zhu, MD (Postdoctoral Research Fellow)
Current position: Research Technologist at Mucosal Immunology Lab, MGH
2005-2006 Ondulla Foye-Jackson, Ph.D. (Postdoctoral fellow)
Current position: Research Molecular Biologist. USDA, ARS, ANRI, ABBL. Beltsville, MD
2005 Qingping Zhou, Ph.D. (Visiting Scientist).
Current position: Professor, Vice-president of Qinghai Academy of Animal Sciences and Veterinary Medicine, Qinghai University. China.
2005 Yuling Li, Ph. D. (Visiting Scientist).
Current position: Professor. Qinghai University, China.
2005-2007 Meiqian Weng, MD, Ph.D. (Postdoctoral fellow)
Current position: Postdoctoral fellow, MGH, Boston.
2006-2007 I-Fei Huang, MD (Research Fellow)
Current position: Assistant Professor at Department of Pediatrics, Kaohsiung Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan
Current postdoctoral fellows:
2008- Yue Cao, M.D., Ph. D.
2008- Michelle Conroy, MD.
2008- Chienwen Su, Ph. D.
Research Technologists and Students:
2001-2004 Steve Louie, Research technologist
Current position: Research Scientist. Novartis Institutes for Biomedical Research, Cambridge, MA
2005 Lijian Wang, Harvard Ph.D. student. (Rotation in the lab)
2005-2007 Deke Huntley, Research technologist.
2004 Sonia Miller, Undergraduate student from DePauw University.
Current position: Medical Student at Harvard Medical School.
2005 Aliese Sarkissian, Undergraduate student from DePauw University.
Current position: Medical Student at Indiana University
2007 Shuo Li, Undergraduate student from DePauw University.
Current Summer Students:
2008 Allyson Mcleod: Undergraduate student from DePauw University.
2008 Diana Lu: Undergraduate student from Tufts University.
2. Regional, National and International Contributions:
1991 Workshop presentation. American Society of Parasitologists, Madison, Wisconsin
1992 Mini workshop presentation. Canadian Society for Immunology, Montreal, Canada
1992 Workshop presentation. Canadian Society of Zoology. Nova Scotia, Canada
1993 Graduate Student presentation. American Society of Tropical Medicine and Hygiene, American Society of Parasitologists, Atlanta, Georgia
1994 Graduate Student presentation. Canadian Federation of Biological Societies. Montreal, Canada
1994 Workshop presentation. American Society of Parasitologists, Ft Collin, CO.
2000 Workshop presentation. American Association of Immunologists, Seattle, Washington
2001 11th Annual Symposium presentation. Center for the Study of Inflammatory Bowel Disease at Mass. General Hospital. Boston.
2006 Conference Presentation. 2006 Crohn’s and Colitis Foundation of America. Fifth Annual Advance in the Inflammatory Bowel Diseases. Miami, Fl.
Invited seminar:
1999 Invited speaker: Qinghai University, School of Veterinary Medicine. Qinghai, China.
1999 Invited Seminar. Qinghai Medical College. Xining, China.
2005 Invited lecture. Qinghai University School of Medicine. Qinghai, China.
2005 Invited lecture. National Institute of Biological Science, Beijing, China.
2006 Invited Research Seminar. MGH Gastrointestinal Unit and the Center for the Study of Inflammatory Bowel Disease (CSIBD).
2007 Invited seminar. Department of Pediatrics. Massachusetts General Hospital, Boston, MA.
2007 Invited Seminar. Biomedical Sciences, University of California, Riverside, California.
2007 Invited Seminar. “Immunomodulation of bacterial enterocolitis by intestinal helminth infection. Division of Comparative Medicine, Massachusetts Institute of Technology (MIT), Cambridge. MA.
2008 Invited lecture “Helminths and intestinal inflammation” at Sun Yat-sen University, Guangzhou, China.
2008 Invited lecture “Immunoregulation of mucosal immunity” at Qinghai University, China
PART III: Bibliography:
Original Articles
1. Shi HN, Scott ME, Stevenson MM, Koski KG. Zinc deficiency impairs T cell function in mice with primary infection of Heligmosomoides polygyrus (Nematoda). Parasite Immunology. 1994: 16: 339-350.
2. Hai Ning Shi, Marilyn E. Scott, Kristine G. Koski, Marjolaine Bouley and Mary M. Stevenson. Energy restriction and severe zinc deficiency influence development, survival and reproduction of Heligmosomoides polygyrus (Nematoda) during primary and challenge infections in mice. Parasitology. 1995; 110: 599-609.
3. Hai Ning Shi, Kristine G. Koski, Mary M. Stevenson and Marilyn E. Scott. Zinc deficiency and energy restriction modify immune responses in mice during both primary and challenge infection with Heligmosomoides polygyrus (Nematoda). Parasite Immunology. 1997;19: 363-373.
4. Hai Ning Shi, Marilyn E. Scott, Kristine G. Koski and Mary M. Stevenson. Zinc deficiency and concurrent energy restriction reduce the functions of murine T cells and antigen-presenting cells during a gastrointestinal nematode infection. Journal of Nutrition. 1997; 128: 20-27.
5. Hai Ning Shi, Christian Ingui, Ingrid Dodge and Cathryn Nagler-Anderson. A helminth induced mucosal Th2 response alters non-responsiveness to oral administration of a soluble antigen. Journal of Immunology. 1998, 160: 2449-2455.
6. Hai Ning Shi, Michael J. Grusby and Cathryn Nagler-Anderson. Orally induced peripheral nonresponsiveness is maintained in the absence of functional Th1 or Th2 cells. Journal of Immunology. 1999, 162; 5143-5148.
7. James G. Fox, Paul Beck, Charles A Dangler, Mark T. Whary, Timothy C. Wang, Hai Ning Shi and Cathryn Nagler-Anderson. Concurrent enteric infection modulates inflammation, gastric immune responses, and reduces helicobacter-induced gastric atrophy. Nature Medicine. 2000; 6 (45): 536-542.
8. Hai Ning Shi, Hao Yuan Liu and Cathryn Nagler-Anderson. Enteric infection acts as an adjuvant for the response to a model food antigen. Journal of Immunology. 2000, 165:6174-6182.
9. Bashir ME, Andersen P, Fuss IJ, Shi HN, Nagler-Anderson C. An enteric helminth infection protects against an allergic response to dietary antigen. Journal of Immunology. 2002, 169(6):3284-3292.
10. Bashir MEH, Louie S., Shi H.N. and Nagler-Anderson C. TLR4 signaling by intestinal microbes influences susceptibility to food allergy. 2004. Journal of Immunology. 172(11): 6978-87.
11. Moran ST, Cariappa A, Liu H, Boboila C, Shi HN, Holland PM, Peschon JJ, Pillai S. Protein kinase C-associated kinase is not required for the development of peripheral B lymphocyte populations. Mol Immunol. 2005.
12. Annaiah Cariappa, Irina B. Mazo, Catharine Chase, Hai Ning Shi, Haoyuan Liu, Qian Li, Harris Rose, Harry Leung, Bobby J. Cherayil, Paul Russell, Ulrich von Andrian, and Shiv Pillai. Perisinusoidal B Cells in the Bone Marrow Participate in T-Independent Responses to Blood-Borne Microbes. Immunity. 2005. 23 (4): 397-407.
13. Chien-Chang Chen, Steve Louie, Beth McCormick, Allan Walker and Hai Ning Shi. Concurrent infection of an intestinal helminth parasite impairs host resistance to enteric Citrobacter rodentium and enhances Citrobacter-induced colitis in mice. 2005. Infection and Immunity. 73 (9): 5468-5481.
14. Chien-Chang Chen, Hai Ning Shi and Allan Walker. Precolonization with the Probiotic Lactobacillus acidophilus early in life effectively inhibits murine Citrobacter rodentium colitis. Pediatric Research. 2005. 58 (6): 1185-1191.
15. Tor C. Savidge, Paul G. Newman, Wei-Hua Pan, Mei-Qian Weng, Hai Ning Shi, Beth A. McCormick, Andrea Quaroni, W. Allan Walker. Lipopolysaccharide-induced human enterocyte tolerance to cytokine-mediated interleukin-8 production may occur independently of TLR-4/MD-2 signalling. Pediatric Research. 2006. 59 (1): 85-95.
16. Chien-Chang Chen, Steve Louie, Beth McCormick, Allan Walker and Hai Ning Shi. Helminth primed dendritic cells alter the host response to enteric bacterial infection. The Journal of Immunology. 2006. 176: 472-483.
17. Wall, D.M, Nadeau, W.J, Pazos, M.A, Shi, H.N, Galyov, E.E, McCormick, B.A. Identification of the Salmonella enterica serotype Typhimurium SipA domain responsible for inducing neutrophil recruitment across the intestinal epithelium. Cellular Microbiology. 2007. 9(9): 2299-2313.
18. Harrington, Lynne; Srikanth, Chittur; Antony, Reuben; Shi, Hai Ning; Cherayil, Bobby. A role for natural killer cells in intestinal inflammation caused by infection with Salmonella enterica serovar Typhimurium. FEMS Immunol Med. Microbiol. 2007. 51: 372–380
19. Annaiah Cariappa, Cristian Boboila, Stewart T. Moran, Haoyuan Liu, Hai Ning Shi, and Shiv Pillai. The Recirculating B Cell Pool Contains Two Functionally Distinct, Long-Lived, Posttransitional, Follicular B Cell Populations. The Journal of Immunology. 2007. 179(4): 2270-2281.
20. Meiqian Weng, Deke Huntley, I-Fei Huang, Ondulla Foye-Jackson, Lijian Wang, Aliese Sarkissian, Qingping Zhou, W. Allan Walker, Bobby J. Cherayil and Hai Ning Shi. Alternatively activated macrophages in intestinal helminth infection: effects on concurrent bacterial colitis. The Journal of Immunology. 2007. 179:4721-4731.
21. Lynne Harrington, Chittur V. Srikanth, Reuben Antony, Sue J. Rhee, Andrew L. Mellor, Hai Ning Shi, and Bobby J. Cherayil. 2008. Deficiency of Indoleamine 2,3-Dioxygenase Enhances Commensal-Induced Antibody Responses and Protects against Citrobacter rodentium-Induced Colitis. Infection and Immunity. Vol. 76: 3045-3053.
22. Yasuyo Shimomura, Atsuhiro Ogawa, Mayumi Kawada, Ken Sugimoto, Emiko Mizoguchi, Hai-Ning Shi, Shiv Pillai, Atul K. Bhan, and Atsushi Mizoguchi. 2008. A unique B2 B cell subset in the intestine. The Journal of Experimental Medicine, Vol. 205, No. 6, 1343-1355.
23. Lijian Wang, Erin E. Johnson, Hai Ning Shi, W. Allan Walker, Marianne Wessling-Resnick, Bobby J. Cherayil. 2008. Attenuated inflammatory responses in hemochromatosis reveal a role for iron in the regulation of macrophage cytokine translation. The Journal of Immunology. 2008. 181 (4) 2723-2731.
24. Michael Pazos, Dario Siccardi, Karen L. Mumy, Jeffrey D. Bien, Steve Louie, Hai Ning Shi, Karsten Gronert, Randall J. Mrsny, and Beth A. McCormick. Multi-Drug Resistance Transporter 2 Regulates Mucosal Inflammation by Facilitating the Synthesis of Hepoxilin A3. The Journal of Immunology. 2008. In press
Reviews, Chapters, and Editorials:
1. Hai Ning Shi and Cathryn Nagler-Anderson. Mucosal T cell responses to enteric infection. Current Opinion in Gastroenterology, 1999, 15: 529-533.
2. Cathryn Nagler-Anderson and Hai Ning Shi. The induction of peripheral non- responsiveness to orally administered soluble antigens. Critical Reviews in Immunology 2001, 21:121-131.
3. Hai Ning Shi and W. Allan Walker. T helper cell subclasses and clinical disease states. Current Opinion in Gastroenterology. 2002, 18(6): 711-716.
5. Hai Ning Shi and W. Allan Walker. Bacterial colonization in the developing gastrointestinal tract: Role in the pathogenesis of intestinal diseases. Bioscience Microflora. 2004, 23(2):55-65.
6. Shi HN and Walker A. Bacterial colonization and the development of intestinal defences. Can J Gastroenterol. 2004. 18(8): 493-500.
7. Hai Ning Shi and Walker A Walker. The role of TIM-4 in food allergy. Gastroenterology. 2007. 133: 1723-1726.
8. Lijian Wang, Yue Cao and Hai Ning Shi. Helminth infections and intestinal inflammation. World J Gastroenterol. 2008 Sep 7;14(33):5125-32
Conference Abstracts:
1. Marilyn E. Scott, Farzaneh Jalili and Hai Ning Shi. Comparison of resistance to Heligmosomoides polygyrus trickle infection in C57BL/6 and Balb/C mice. 66th Annual Meeting of The American Society of Parasitologists (Madison, Wisconsin), 1991: 138.
2. Hai Ning Shi, Mary M. Stevenson, Kristine G Koski and Marilyn E. Scott. Impairment of DTH and cytokine production in zinc deficient mice infected with Heligmosomoides polygyrus. Sixth Spring Meeting of The Canadian Society for Immunology (Mont Rolland, Montreal, Canada), 1992; 2.14.
3. Hai Ning Shi, Marilyn E. Scott, Mary M. Stevenson and Kristine G. Koski. Effects of zinc deficiency on Heligmosomoides polygyrus in mice. Canadian Society of Zoology (Nova Scotia, Canada), 1992.
4. Hai Ning Shi, Marilyn E. Scott, Mary M. Stevenson and Kristine G. Koski. The role of zinc in host immunity and Heligmosomoides polygyrus infection. XIIIth International Congress for Tropical Medicine and Malaria (Jomtien, Pattaya, Thailand), 1992.
5. Hai Ning Shi, Marilyn E. Scott, Mary M. Stevenson and Kristine G. Koski. Zinc deficiency affects Heligmosomoides polygyrus during both primary and challenge infection in mice. Joint Meeting of The American Society of Tropical Medicine and Hygiene and American Society of Parasitologists (Atlanta, USA), 1993; 152.
6. Hai Ning Shi, Mary M. Stevenson, Marilyn E. Scott and Kristine G. Koski. Functional studies and cytometric analysis of splenic T cells of zinc deficient mice infected with Heligmosomoides polygyrus. Eighth Spring Meeting of the Canadian Society of Immunology (Le Chantecler, Sainte-Adele, Quebec, Canada), 1994; 2.
7. Hai Ning Shi, Marilyn E. Scott, Mary M. Stevenson and Kristine G. Koski. Effects of zinc deficiency and energy restriction on host immunity on an intestinal nematode infection of mice. Canadian Federation of Biological Societies, 37th Annual Meeting (Montreal, Canada), 1994: 228.
8. Hai Ning Shi, Marilyn E. Scott, Mary M. Stevenson and Kristine G. Koski. Experimental zinc deficiency: effect on antibody responses in mice with Heligmosomoides polygyrus infection. Annual Meeting of the American Society of Parasitologists (FT. Collins, CO. USA), 1994.
9. Hai Ning Shi, Mary M. Stevenson, Marilyn E. Scott and Kristine G. Koski. Effects of zinc deficiency on response of T cells and antigen-presenting cells to Heligmosomoides polygyrus in mice. The 9th International Congress of Immunology (San Francisco, CA), 1995.
10. Hai Ning Shi, Christian Ingui, Ingrid Dodge and Cathryn Nagler-Anderson. A helminth induced mucosal Th2 response alter non-responsiveness to oral administration of a soluble antigen. Experimental Biology 1998 (San Francisco, CA), FASEB Journal 1998, 12:A3463.
11. Hai Ning Shi, Hao Yuan Liu and Cathryn Nagler-Anderson. Enteric infection acts as a mucosal adjuvant for the response to oral antigens. Annual Meeting of American Gastroenterology Association (Florida), 1999. Gastroenterology 116, A818.
12. Fox, J.G., P. Beck, C. A. Dangler, T. Wang, M. T. Whary, H. N. Shi and C. Nagler-Anderson. Solving the African enigma: coinfection with an intestinal parasite modulates inflammation and reduces gastric atrophy in a mouse model of Helicobacter infection. 10th International workshop on Campylobacter, Helicobacter and related organisms, 1999
13. Fox, J. G., P. Beck, C. A. Dangler, T. Wang, M. T. Whary, H.N. Shi and C. Nagler-Anderson. Modulation of the Th1/Th2 response with Heligmosomoides polygyrus and Helicobacter felis coinfection in mice: an animal model to study the “African enigma”. 10th International workshop on Campylobacter, Helicobacter and related organisms, 1999.
14. Hai Ning Shi, Hao Yuan Liu and Cathryn Nagler-Anderson. Adjuvant effect of intestinal helminth infection on the response to a model food antigen. Immunology 2000 (AAI, Seattle, Washington, May 12-16, 2000). The FASEB Journal, Vol. 14. No.6, 183.5
15. Fox, J. G., C. A. Dangler, P. Beck, T. Wang, M.T. Whary, H.N. Shi and C. Nagler-Anderson. Intestinal helminth infection modulates inflammation and reduces gastric atrophy in a mouse model of Helicobacter infection. Annual Meeting of the American Gastroenterological Association (San Diego, CA), 2000. Gastroenterology 118, 1226.
16. Bashir M E.H., H.N. Shi, P. Andersen, E.I. Melendro and C. Nagler-Anderson. Enteric helminth infection does not induce an allergic response to a food antigen. Annual Meeting of American Gastroenterology Association (DDW), Atlanta, 2001.
17. Whary M.T., H.N. Shi, H. White, C. Nagler-Anderson and J.G. Fox. Th2 response to the helminth Heligmosomoides polygyrus reduce Th1-promoted epithelial hyperplasia in a mouse model of Helicobacter hepaticus-associated inflammatory bowel disease (IBD). Annual Meeting of American Gastroenterology Association (DDW), Atlanta, 2001.
18. Shi, H.N., M.E.H. Bashir, P. Andersen, E.I. Melendro and C. Nagler-Anderson. Impact of intestinal helminth infection on the host allergic response to dietary antigens. Fifth Annual Woods Hole Immunoparasitology Meeting, 2001
19. M. T. Whary, HN. Shi, H. White, C. Nagler-Anderson, J. G. Fox. Th2 Responses to the Helminth Heligmosomoides polygyrus Reduce Th1-Promoted Epithelial Hyperplasia in a Mouse Model of Helicobacter hepaticus-Associated Inflammatory Bowel Disease (IBD). European Helicobacter Study Group, Strasbourg Workshop 2001.
20. Donald Smith, Onyinye Iweala, Hai Ning Shi and Cathryn Nagler-Anderson. Presentation of model immunogenic and tolerogenic antigens by the gut associated lymphoid tissue. Keystone Symposia. CO. 2002
21. Cathryn Nagler-Anderson, Mohamed E.H. Bashir, Emma I. Melendro, Donald Smith, Onyinye Iweala and Hai Ning Shi. Regulation of tolerance and immunity in the intestinal mucosa. Keystone Symposia. CO. 2002
22. Cathryn Nagler-Anderson, Hai Ning Shi, Weishu Zhu, Steve Louie, Mohamed Elfatih B. Bashir. TLR-4 signaling by intestinal microbes influences susceptibility to food allergy. AAI, Washington D.C., April 17-21, 2004.
23. Chien-Chang Chen, Steve Louie, Weishu Zhu, Beth McCormick, Allan Walker and Hai Ning Shi. Intestinal helminth infection impairs host resistance and enhances colonic pathology during concurrent Citrobacter rodentium infection in mice. Annual Meeting of American Gastroenterology Association (DDW, New Orleans, LA.). Gastroenterology. 126(4). Suppl2. M1066, 2004.
24. Chien-Chang Chen, Steve Louie, Allan Walker and Hai Ning Shi. Precolonization with the Probiotic Lactobacillus acidophilus early in life effectively inhibit murine Citrobacter rodentium colitis. Annual Meeting of American Gastroenterology Association (DDW, Chicago). May 14-19, 2005.
25. Bobby Cherayil, Lynne Harrington, Reuben Antony and Hai Ning Shi. An important role in acute Salmonella induced enteritis. American Association of Immunologists Meeting, Boston, May 12-16, 2006.
26. Meiqian Weng, Deke Huntley, Ondulla Foye-Jackson, Lijian Wang, W. Allan Walker, Bobby Cherayil and Hai Ning Shi. Alternatively activated macrophages in intestinal helminth infection: effects on concurrent bacterial enteritis. CCFA National Research and Clinical Conference. Fifth Annual Advances in the Inflammatory Bowel Diseases. Miami, Florida. December 1-3, 2006
27. Meiqian Weng, Deke Huntley, Lijian Wang, Ondulla Foye-Jackson, W. Allan Walker, Bobby Cherayil and Hai Ning Shi. The role of helminth-induced alternatively activated macrophages in concurrent bacterial enteritis. Annual Meeting of American Gastroenterology Association (DDW, Washington D.C.). May 19-24. 2007
28. Weng, Meiqian; Wang, Lijian; Li, Shuo; Walker, W. Allan; Cherayil, Bobby J.; Shi, Hai Ning. Helminth-induced alternatively activated macrophages in bacterial colitis: impaired autophagy as a mechanism of exacerbated intestinal inflammation in Citrobacter infection. Annual Meeting of American Gastroenterology Association (DDW, San Diego, CA). May, 2008
Ph. D. Thesis:
Hai Ning Shi. Interactions among zinc deficiency, energy restriction, immunity and Helgmosomoides polygyrus (Nematoda) infection in mice. Ph. D. Thesis. Montreal, Canada. McGill University. 1996. 249 pages.
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