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Date Prepared: |
12/19/08 |
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Name: |
N. Nanda Nanthakumar, Ph.D. |
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Office Address: |
Department of Pediatric Gastroenterology & Nutrition |
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Work Phone: |
(617) 726-4180 |
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Work FAX: |
(617) 726-4172 |
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Work E-Mail: |
nanthaku@helix.mgh.harvard.edu |
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Education |
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1985 |
BSc |
Zoology (Hons.) |
University of Houston, Houston, TX |
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1992 |
PhD |
Cell, Developmental and Molecular Biology |
University of Peradeniya, Sri Lanka |
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Professional Experience |
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9/85 – 9/86 |
Assistant Lecturer |
University of Peradeniya, Peradeniya, Sri Lanka |
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9/86 – 8/87 |
Research Assistant |
Open University, Colombo, Sri Lanka |
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9/87 – 1/89 |
Teaching Assistant |
University of Houston, Houston, TX |
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1/89 – 2/93 |
Research Assistant |
Baylor College of Medicine, Houston, TX |
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2/93 – 1/98 |
Research Associate |
Duke University Medical Center, Durham, NC |
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1/98 – 2005 |
Assistant Biologist |
Massachusetts General Hospital, Boston |
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1/98 – 2005 |
Instructor in Pediatrics |
Harvard Medical School, Boston |
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1999 – |
Associate Member |
Harvard Clinical Nutrition Research Center, Boston |
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1999 – |
Associate Member |
Center for the Study of Inflammatory Bowel Disease (CSIBD), Boston |
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2000 – |
Associate Member |
Dana-Farber Harvard Cancer Center (DFHCC), Boston |
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2004 – |
Co-Director |
Animal and Morphology Core, Harvard Clinical Nutrition Research Center, Boston |
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2005 – |
Assistant Professor in Pediatrics |
Harvard Medical School, Boston |
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Honors and Awards: |
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1986 – 1987 |
Research Fellowship |
Natural Science Authority of Sri Lanka |
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1987 |
Smithsonian Research Fellow |
National Zoological Park, Washington D.C. |
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1989 |
Research Award |
Sigma Xi Grant-in-Aid |
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1989 |
Student Fellowship |
American Gastroenterological Society |
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1989 |
Teaching Excellence Award |
Department of Biology, University of Houston |
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1989 |
College of Natural Science Endowment Scholarship |
University of Houston |
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1990 |
Student Fellowship |
Endocrine Society |
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1994 - 1996 |
Post Doctoral Fellowship |
NIH-NRSA: |
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1998 |
NIH: HD12437-S1 |
Research Supplement for Under-represented minorities – Nanda Nanthakumar |
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1999 |
Pilot Feasibility Grant |
Center for the Study of Inflammatory Bowel Disease, MGH, Boston |
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2004 |
Pilot Feasibility Grant |
Harvard Clinical Nutrition Research center, MGH, Boston |
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2007 |
Interim Support Fund |
Massachusetts General Hospital: Executive Committee on Research: |
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2008 |
R01HD059126-0i1 |
Title: “Maturation of intestinal innate immunity and NEC” |
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2008 |
Bridge Grant |
Massachusetts General Hospital: Executive Committee on Research: |
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Memberships |
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American Society for Cell Biology |
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American Society for Microbiology |
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American Gastroenterological Association |
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American Society for Mucosal Immunologist |
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American Association for the Advancement of Science |
B. Publications |
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1. |
Chandrasena, G, I Sunitha, C Lau, NN Nanthakumar,?isomaltase mRNA along the crypt villus axis in the rat small intestine. Cell. Molec. Biol. 38: 243–254. |
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2. |
Inui, Y, AML Hausman, NN Nanthakumar, SJ Henning, NO Davidson. (1992) Apolipoprotein B messenger RNA editing in rat liver: Developmental and hormonal modulation is divergent from apolipoprotein A-IV gene expression despite increased hepatic lipogenesis. J. Lipid Res. 33: 1843–1856. |
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3. |
Nanthakumar, NN, SJ Henning. (1993) Ontogeny of sucrase-isomaltase gene expression in rat small intestine: Responsiveness to glucocorticoids. Am. J. Physiol. 264: G306–G311. |
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4. |
Needleman, DS, LL Leeper, NN. Nanthakumar, SJ Henning. (1993) Hormonal regulation of the mRNA for cysteine-rich intestinal protein in rat jejunum during maturation. J. Pediatr. Gastr. Nutr. 16: 15–22. |
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5. |
Nanthakumar, NN, SJ Henning. (1994) Differentiating Glucocorticoid-Induced Maturation From Normal Development Using 5-Bromo-2’-Deoxyuridine (BUdR). Am. J. Physiol. 265: G216–G221. |
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6. |
Henning, SJ, NN Nanthakumar. (1994) Development of intestinal disaccharidases: A plurality of mechanisms. In: Mammalian Brush Border Membrane Proteins II. Ed: M. J. Lenze, H. Y. Naim and R. J. Grand: Georg Thieme Verlag, Stuttgart: page 243-249. |
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7. |
Lu, KP, NN Nanthakumar, JS Dayton, AR Means. (1995) Calcium and Calmodulin regulation of the nuclear division cycle of Aspergillus nidulans. In: Advances in Molecular and Cellular Biology., Ed: M. Wittaker: JAI Press Inc., Connecticut: Vol. 13; page 89-136. |
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8. |
Nanthakumar, NN, JS Dayton, AR Means. (1996) Role of Ca++/Calmodulin binding proteins in Aspergillus nidulans cell cycle regulation In: Progress in Cell Cycle Research. Vol.2, Ed: L. Meijer: Plenum, NY. |
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9. |
Dayton, JS, M Sumi, NN Nanthakumar, AR Means. (1997) Expression of constitutively active Ca++/Calmodulin dependent protein kinase in Aspergillus nidulans spores prevents germination and entry into the cell cycle. J. Biol. Chem. 272: 3223-3230. |
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10. |
Oesterreicher, TJ, NN Nanthakumar, JH Winston, SJ Henning. (1998) Cloning of rat trehalase cDNA and studies of the influence of glucocorticods on the ontogenic expression of trehalase mRNA in the small intestine. Am. J. Physiol. 274: R1220–R1227. |
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11. |
Dai D, NN Nanthakumar, DS Newburg, WA Walker. (2000) The role of oligosacharides and glycoconjugates in intestinal host defense. J. Pediatr. Gastr. Nutr. 30: S23-S33. |
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12. |
Nanthakumar NN, RD Fusunyan, IR Sanderson, WA Walker (2000) Endotoxin interaction with the developing human intestine: Pathophysiologic basis for necrotizing enterocolitis. Proc Natl Acad Sci., 97: 6043-6048. |
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13. |
Beck PL, R Xavier, N Lu, NN Nanthakumar, M Dinauer, Dk Podolsky, B Seed (2000) Mechanisms of NSAID-induced gastrointestinal injury defined using mutant mice. Gastroenterology 119:699-705 |
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14. |
Fusunyan R, NN Nanthakumar, Baldeon, ME, Walker WA. (2001) Evidence for an innate immune response in the immature intestine: Toll-like receptors on fetal enterocytes. Pediatric Research 49:589-593. |
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15. |
Nanthakumar NN. (2001) The Regulation of functional development of the small intestine. In: Gastrointestinal functions, Ed: E. Delvin and MJ Lentze. NestlŽ Nutrition Workshop Series, Vol 46, NestlŽ Ltd., Vevey/Lippincott Williams & Wilkins, Philadelphia: pp 39-58. |
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16. |
Dai D, NN Nanthakumar, T Savidge, DS Newburg, WA Walker. (2002) Tissue specific developmental ?sialytransferase. Am. J. Physiol. 282: G480–G490. |
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17. |
Nanthakumar NN, D Dai, DS Newburg, WA Walker. (2003) The induction of glycosyltransferases by colonizaing bacteria in germ free animal. The FASEB J.: G480–90. |
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18. |
Nanthakumar NN, CE Klopcic, I Fernandez, and Walker WA. (2003) Normal and glucocorticoid induced development of the human jejunal and ileal xenografts. Am. J. Physiol, 285: R162-70. |
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19. |
Nanthakumar N, Walker WA. (2003) Human intestinal development and maturation. In The small intestine Ed: MN Marsh and EMM Quiqley, Academic Press. Pp 1-24. |
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20. |
Nanthakumar N, Walker WA. (2004) The role of Bacteria in the Development of Intestinal Protective Function. In: Allergic Diseases and the Environment, Ed: W. A. Walker and E. Isolauri. NestlŽ Nutrition Workshop Series, Vol 53, NestlŽ Ltd., Vevey/Lippincott Williams & Wilkins, Philadelphia: In Press. |
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21. |
Nanthakumar NN, D Dai, D Meng, N. Chaudry, DS Newburg, WA Walker. (2005) Regulation of Intestinal Ontogeny: Effect of glucocorticoids and luminal microbes on Galactosyltransferase and Trehalase induction in mice. Glycobiology, 15(3):221-232. |
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22. |
Nanthakumar NN, C Young, JS Ko, D Meng, J Chen, T Buie, W.A Walker. (2005) Glucocorticoid responsiveness in the developing human intestine: A possible role in the prevention of necrotizing enterocolitis. Am. J. Physiol.; 288(1): G85-92. |
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23. |
Long KZ, Estrada-Garcia T, Rosado JL, Santos JI, Haas M, Firestone M, Bhagwat J, Young C, Dupont HL, Hertzmark E, Nanthakumar NN. (2006) The effect of vitamin a supplementation on the intestinal immune response in mexican children is modified by pathogen infections and diarrhea. J Nutr. 136(5): 1365-70. |
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24. |
Long KZ, Santos JI, Estrada Garcia T, Haas M, Firestone M, Bhagwat J, Dupont HL, Hertzmark E, Rosado JL, Nanthakumar NN. Vitamin A supplementation reduces the monocyte chemoattractant protein-1 intestinal immune response of Mexican children. J Nutr. 2006 Oct;136(10):2600-5. |
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25. |
Broekaert IJ, Nanthakumar NN, Walker WA. Secreted probiotic factors ameliorate enteropathogenic infection in zinc-deficient human Caco-2 and T84 cell lines. Pediatr Res. 2007 Aug;62(2):139-44. |
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26. |
Meng D, Newburg DS, Young C, Baker A, Tonkonogy SL, Sartor RB, Walker WA, NN Nanthakumar. Bacterial symbionts induce a FUT2-dependent fucosylated niche on colonic epithelium via ERK and JNK signaling. Am J Physiol Gastrointest Liver Physiol. 2007 Oct;293(4):G780-7. |
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27. |
Chen X, Katchar K, Goldsmith JD, Nanthakumar N, Cheknis A, Gerding DN, Kelly CP. A Mouse Model of Clostridium difficile-Associated Disease. Gastroenterology. 2008 Sep 10. [Epub ahead of print] |
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28. |
Nanthakumar NN, D Meng, A Goldstein, R Uauy, EC. Claud, WA Walker. Probiotics prevent Necrotizing Enterociolitis by affecting genes that regulate intestinal inflammation. Gastroenterology, Submitted. |
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29. |
J-S Ko, M Hass, Di Meng, S Prajapathi, L Scheidler, WA Walker, NN Nanthakumar. The probiotic Lactobacillus plantarum attenuates enteric pathogenic adhesion, invasion and the inflammatory response in human intestine. Pediatric Research, Submitted. |
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30. |
Di Meng, W Zhu, WA Walker, and NN Nanthakumar. Induction of colonic epithelial fucosylation is mediated by gram-negative bacteria through a novel fucosylated TLR-4 sentinel receptor. In preparation. |
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31. |
Dubert-Ferrandon A, Nanthakumar NN, Rautava S, Moore D, Lu L, Pothoulakis C, Walker WA, Newburg DS. B-Galacto-oligosaccharides directly modulates TNF-a-induced inflammatory response in human intestinal epithelial cells. J Nutr. Submitted. |
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32. |
Rautava S, NN Nanthakumar, A Dubert-Ferrandon,L Lu, J Rautava, WA Walker. Transforming growth factor-β2 attenuates pro-inflammatory responses in immature human intestinal epithelial cells by inhibiting the ERK pathway through a SMAD6-dependent mechanism. In preparation. |
C. Research Support |
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PO1 DK33506-20 |
PI: W. Allan Walker |
09/30/05-08/31/10 |
NIDDK |
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Barrier Function of the GI Tract in Health and Disease |
Role: Co-Investigator Project 1 |
Xenograft and Animal Core: PI |
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RO1 DK070260-11 |
PI: W. Allan Walker |
05/1/05-4/30/10 |
NIDDK |
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Role: Co-Investigator |
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R37 HD12437-26 |
PI: W. Allan Walker |
1/1/06-12/31/11 |
NIDDK |
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The Effect of Colostrum on Gut Maturation and Host Defense |
Role: Investigator |
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2007A052008 |
PI: N. Nanda Nanthakumar |
10/01/07-12/31/08 |
MGH/ECOR |
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Inflammation of the immature gut |
Role: PI |
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R01HD059126-01 |
PI: N. Nanda Nanthakumar |
Pending |
NICHD |
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Maturation of intestinal innate |
Role: PI |
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Previous Trainees |
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1998 |
Corrie Klopcic |
Fellow |
Pediatric Emergency Care, Texas Children Hospital, TX, |
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1998 - 2001 |
Robert Fusunyan |
Assistant Professor |
Massachusetts General Hospital, Boston |
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1998 - 2002 |
Ding-Wei Dai |
Fellow |
University of Novo Scotia, Canada |
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1999 |
Nassar Mouideen |
Pediatric Cardiology Fellow |
Hospital for Sick Children, Toronto, Canada |
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2000 |
Allison Frank |
Resident |
Vanderbilt University, Nashville, TN |
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2001 |
Kristin Spellmayer |
Resident |
Indiana University Medical School, IN |
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2002 |
Cheryl Young, MD, PhD |
Student |
Emory University Medical School, Atlanta, GA |
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2002 – 2004 |
Jae-Sung Ko |
Assistant Professor |
Seoul National University, South Korea |
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2002 – |
Di Meng |
Instructor |
Massachusetts General Hospital, Boston |
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2002 – 2003 |
Matt Firestone |
Graduate Student |
University of California, Berkeley, CA |
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2002 – 2003 |
Sarina Pasricha |
Medical Student |
Feinberg School of Medicine, Northwestern University, IL |
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2003 |
Meredith Hass |
Research Associate |
Indiana University Medical School, IN |
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2003 |
Neha Chaudry |
Graduate Student |
University of Chicago, Chicago |
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2003 |
Luke Scheidler |
Research Associate |
Fish and Wildlife Service, Honolulu HI |
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2004 |
Sudeep Prajapati |
Graduate Student |
Cornel University Medical Center, NY |
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2004 – 2006 |
Ilse Broekaert |
Pediatric Gastroenterology Fellow |
Massachusetts General Hospital, Boston |
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2005 |
Sanjeeve Martyn |
Medical Student |
Georgetown University Medical School, Washington, D.C. |
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2005 |
Rex Pillai |
Medical Student |
St. George’s University Medical School, NY |
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2005 |
Amy Baker |
Masters in Medical |
Indiana University Medical School, IN |
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2006 |
Rupak Shivakodi |
Graduate Student |
Mount Sinai Medical Center, NY |
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2006 |
Meena Theva |
Medical Student |
Boston University Medical School, Boston |
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2006 |
Alex Theventhiran |
Medical Student |
Rosalind Franklin University of Medicine, Chicago |
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2005 – |
Wei-Shu Zhu |
Research Fellow |
Massachusetts General Hospital, Boston |
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2007 |
Jack Cooper |
Graduated |
DePauw University, Greencastle, IN |
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2007 |
Jing Shi |
Senior |
Brandies University, Waltham, MA |
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2007 – |
Alix Dubert-Ferrandon |
Post-Doctoral Fellow |
Massachusetts General Hospital, Boston |
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2008 |
David Moore |
Senior |
DePauw University, Greencastle, IN |
