Curriculum Vita

Di Meng, MD, PhD
Instructor of Pediatrics

GENERAL INFORMATION

Name: Di Meng

Office Address:

Massachusetts General Hospital,
Building 114, Room 3625,
16th Street,
Charlestown, MA 02129

E-mail: dmeng@helix.mgh.harvard.edu

Phone: 617-726-7991
Fax:  617-726-4172

Place of Birth:

Education:

1987- MD -  Xuzhou Medical College, China  ( Medicine ) 
1996 – MS - Shanghai Second Medical University, China (Pediatrics and Neonatal intestinal Nutrition)
1999 – Ph.D - Shanghai Second Medical University, China (Developmental Biology)

Postdoctoral Training:

2001-2003 – Research Fellow, Department of Pediatrics / Mucosal Immunology Laboratory Massachusetts General Hospital, Charlestown MA

2003-2007 – Research Associate, Department of Pediatrics / Mucosal Immunology Laboratory,  Massachusetts General Hospital, Charlestown MA

Academic Appointments:

2007- Current - Instructor, Department of Pediatrics, Harvard Medical School, Boston MA

Hospital or Affiliated Institution Appointments:

1987-1993- Residency in Pediatrics,  Xuzhou Children’s Hospital, China
1993-1999- Shanghai Institute for Pediatric Research, China
1999-2001-Attending Physician in Pediatrics, Shanghai International Peace Maternity and Child  Health Hospital, China
2001-2004 - Research Fellow, Department of Microbiology and Molecular Genetics, Massachusetts General Hospital, Boston MA
2004-2007 - Research Associate in Microbiology, Pediatric Service, Massachusetts General  Hospital, Charlestown, MA
2007- Current - Assistant Microbiologist, Pediatric Service, Massachusetts General Hospital for Children, Charlestown, MA

Memberships in Professional Societies:

2004- Society for Mucosal Immunology (Member)
2005 - American Gastroenterological Association (Member)

Awards and Honors:

2001-2002 - Nestle Reward Scholarship
2001-2004 - Fogarty Research Training Award (D43 Two1265)
2005-2007 - The Danone Institute International Prize for Nutrition
2007 -  Travel Award to attend the FASEB summer conference on "Nutritional Immunology: Its  role   in health and disease".  
2009 -   American Gastroenterological Association (AGA) Scholarship for attending AGA Academic Skills Workshop-2009
2009-2010 -  Wyeth Research Fellowship

Funding Information:

2009-2010 Harvard Clinical Nutrition Research Center (HCNRC) Pilot Feasibility Study, Principal Investigator: Di Meng Ph.D., MD

Published Articles (Within past five years)

1. Di Meng, David Newburg, Cheryl Young, W. Allan Walker, Nanthkumar NN. Bacterial symbiontsc induce a FUT2-dependent fucosylated niche on colonic epithelium via ERK and JNK signaling. Am J Physiol Gastrointest Liver Physiol. 2007; 293:G780-7. PMID:17673542
2. Paul Beck, Eikichi Ihara, Simon Hirota, Justin MacDonald, Di Meng, N. Nanda Nanthakumar, Daniel Podolsky, and Ramnik Xavier. "Exploring the Interplay of Barrier Function and Leukocyte Recruitment in Intestinal Inflammation by Targeting Fucosyltransferase VII and Trefoil Factor 3" Am J Physiol Gastrointest Liver Physiol. 2010 Jul;299(1):G43-53. PMID: 20299601
3. Nanthakumar N, Meng D, Goldstein AM, Zhu W, Lu L, Uauy R, Llanos A, Claud EC, Walker WA. The mechanism of excessive intestinal inflammation in necrotizing enterocolitis: an immature innate immune response. PLoS One. 2011 Mar 21;6(3):e17776. PMID: 21445298

Published Abstracts

1. Di Meng, Weishu Zhu, Kewei Zhang, Rex Pillai, Amy Baker, Sanjeeve
Martyn, W.Allan Walker, Nanda Nanthakumar. Commensal bacteria promote recovery from DSS colitis by inducing MIP2-dependent neutrophil recruitment. Gastroenterology 2007; 132:T1684 A-534
2. Di Meng, David S. Newburg, Cheryl Young, Amy Baker, Susan L. Tonkonogy, R. Balfour Sartor, W. Allan Walker, N. Nanda Nanthakumar. Bacterial symbionts induce their fucosylated niche in mammalian colon via a TLR4 sentinel activating ERK and JNK signaling. Gastroenterology 2007; 132, T1687 A-535
3. Meena Thva, Rupak Shivakodi, Di Meng, David Newburg, W.Allan Walker and N.Nanda Nanthakumar. Salmonella typhimurium utilizes a mannosyl epitope for infecting epithelial cells and a fucodyl epitope for infecting lymphoid cells in the pathogenesis of Salmonellosis. Gastroenterology 2007; 132: A-712
4. Di Meng, Weishu Zhu, Kewei Zhang, W.Allan Walker, and Nanda Nanthakumar. Gram-negative bacterial symbionts stimulate TLR4-mediated protective cytokines in the intestinal mucosa necessary for neutrophil recruitment, and recovery from DSS-induced colitis. 62nd Annual Meeting of the MGH Scientific Advisory Committee 2009. Abstract /Poster Number 74
5. Di Meng, Weishu Zhu, W.Allan Walker, and Nanda Nanthakumar. Colonization-Dependent colonic fucosylation is mediated by gram negative bacteria via activation of a novel fucosylated TLR4. Abstract (#563), 2010 Digestive Disease Week, New Orleans, Louisiana
6. Di Meng, Nanda Nanthakumar . IL-6 and MIP-2 are important for neutrophil and macrophage recruitment during the recovery from colitis in bacteria-depleted mice (Mo 1734), 2011 Digestive Disease Week, Chicago, IL