Curriculum Vita

Lei Lu, MD
Instructor Pediatrics

GENERAL INFORMATION

Name: Lei Lu

Office Address:

Massachusetts General Hospital,
Building 114, Room 3700,
16th Street,
Charlestown, MA 02129

E-mail:

Phone:
Fax:

Place of Birth:

Education:

1987 M.D. Shanghai Medical University, Medicine
1993 M.S. Harvard School of Public Health, Population and International Health

Employment:

1987-1990 – Resident in Reproductive Endocrinology, Obstetrics and Gynecology Hospital, Shanghai Medical University, Shanghai, China; Full-time, Supervisor Ya-ping Zhou, M.D., Sheng-ming Bin, Ph.D.

1993-1995 – Research Assistant in Experimental Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Full-time, Supervisor Edwin Geissler, Ph.D.

1995-1999 – Research Associate in Pediatric GI/Nutrition, Massachusetts General Hospital, Boston, MA; Full-time, Supervisor Barry Wershil, M.D.

1999-2006 – Research Fellow in Developmental Gastroenterology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Full-time, Supervisor Allan Walker, M.D.

2006-    Instructor in Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA

Honors:

1989- 1990 – Young Scientist Award, Shanghai Medical University, Shanghai, China

2001-2003 – Institutional NRSA award

2003- 2005 – AstraZeneca Fellowship/Faculty Transition Award

Professional Societies:

2005-present – American Gastroenterology Association

Publications:

Original research and theoretical treatises

1. Jia G-Q., Gonzalo JA., Lloyd C., Kremer L., Lu L., Martinez-A C., Wershil BK., and Gutierrez-Ramos JC. Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation. Journal of Experimental Medicine 1997; 184: 1939-1951.

2. Furuta GT., Schmidt-Choudhury A., Wang M., Wang Z-S., Lu L., Furlano RI., and Wershil BK. Mast cell-derived tumor necrosis factor alpha participates in immunoglobulin E-dependent gastric inflammation in mice. Gastroenterology 1997; 113: 1560-1569

3. Furuta GT, Ackerman SJ,  Lu L, Williams RE, Wershil BK. Stem cell factor influences mast cell mediator release in response to eosinophil-derived granule major basic protein. Blood1998; 92:1055-1061

4.  Lu L, Mackay C, and Wershil, BK. Pro-inflammatory cytokines induce the expression of eotaxin in Caco2 intestinal epithelial cells. Gastroenterology 1997; 112:A1063

5.  Lu L, and Wershil, BK. Substance P induces eotaxin production by murine mast cells grown in stem cell factor. FASEB 1998; 12:A881

6.  Lu L, Quackenbush EJ, and Wershil, BK. Eotaxin contributes to mast cell-dependent eosinophil recruitment in substance P-induced cutaneous inflammation. FASEB 1999; 13:A490.16
Oral presentation at the FASEB 1999/ Experimental biology annual Meeting, Washington, DC, April 1999

7. Higuchi LM, Lu L, Williams RE, Wershil BK. Mast cell mediator release in response to substance P is associated with stem cell factor-dependent upregulation of Gia -2 and Gia -3 proteins and downstream signaling through a protein kinase C-dependent pathway. Gastroenterology 1998; 114: A377.
Oral presentation at the Digestive Disease Week 1998/ American Gastroenterological Association (AGA) Annual Meeting, New Orleans, LA, May 1998

8.  Lu L, Baldeon ME, Savidge T, Pothoulakis C, Walker WA. Development of microbial-human enterocyte interaction: cholera toxin. The Digestive Disease Week 2003/ American Gastroenterological Association (AGA) Annual Meeting, Orlando, FL, May 2003

9. Lu L, Savidge T, Walker WA. An Age-Dependent Differential Cellular Response to Cholera Toxin in Human Enterocytes. The Digestive Disease Week  2003/ American Gastroenterological Association (AGA) Annual Meeting, Orlando, FL, May 2003

10. Lu L, Baldeon ME, Savidge T, Pothoulakis C, Walker WA. Development of microbial-human enterocyte interaction:cholera toxin. Pediatric Research 2003; 54:212-218200

11. Claud EC, Lu L, Anton PM, Savidge T, Walker WA, Cherayil BJ. Developmentally regulated IkappaB expression in intestinal epithelium and susceptibility to flagellin-induced inflammation. Proc Natl Acad Sci U S A. 2004 May 11;101(19):7404-8.

12.  Lu L, Khan S, Lencer WI and Walker WA.  Endocytosis of cholera toxin by human enterocytes is developmentally regulated. Am. J Physiol. 2005, 289:G332-G431.

13. Lu L, Bao Y, Khan A, Goldstein AM, Newburg DS, Quaroni A, Brown D, Walker WA.  Hydrocortisone Modulates Cholera Toxin Endocytosis by Regulating Immature Enterocyte Plasma Membrane Phospholipids.  Gastroenterology. 2008 135:185-193.e1.

Non-experimental articles

Lu, L and Walker, WA: Pathologic and physiologic interactions of bacteria with the gastrointestinal epithelium. The American Journal of Clinical Nutrition 2001; 73: 1124s-1130s