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Curriculum VitaBryan P. Hurley PhD
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Date Prepared: |
3/2012 |
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Name: |
Bryan P. Hurley Ph.D. |
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Office Address: |
Department of Pediatrics |
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Work Phone: |
(617) 726-3101 |
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Work FAX: |
(617) 726-4172 |
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Work E-Mail: |
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A. Education |
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1994 |
B.A. |
Biology |
College of the Holy Cross |
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2001 |
Ph.D. |
Immunology |
Tufts University Sackler School of Graduate Biomedical Sciences (Thesis advisor, David W.K. Acheson M.D.) |
B. Positions and Honors
Positions and Employment
2004-2007 Instructor of Pediatrics and Microbiology, Harvard Medical School and Massachusetts General Hospital, Boston MA
2007-present Assistant Professor of Pediatrics and Microbiology, Harvard Medical School and Massachusetts General Hospital, Boston MA
Other Experience and Professional Memberships
1999-2000 Graduate school admissions committee: Tufts University
2000 Instructor of Immunology for pre-matriculating medical students: Tufts University
2001-present Mentor to summer research fellows
2002-present Invited Guest Speaker to multiple Industry & Academic Research Units
2003-present Co-Instructor for Molecular Cell Biology course: Massachusetts General Hospital
2004-present Member, American Society for Microbiology
2004-present Member, Society for Mucosal immunology
2005-present Invited peer reviewer for multiple scientific research journals
2006-present Invited peer reviewer for multiple granting agencies devoted to funding basic research
2008-present Presenter, Pediatric GI Journal Club & Clinical Conference
2008-present Supervise post-doctoral fellows and research technicians
2008-present Director of laboratory safety for the Mucosal Immunology Laboratory
2009-present Member, Executive Committee ranking Pediatric Fellows Applicants MGHfC PEDI/GI
2010 Poster Judge, 12th International Winter Eicosanoid Conference
2011-present Member, American Physiological Society
2012 Member, American Association of Immunologists
Honors
2003 Ruth L. Kirschstein National Research Service Award Individual Fellowship (NIH/NIAID)
2008 Cystic Fibrosis Foundation Research Grant Recipient
2008 Research Scholar Development Award (NIH/NIAID)
2011 Awarded Corporate Sponsored Research Contract (Pioneer Hi-Bred International, Inc.)
2011 Awarded Formulaic Bridge Funding Support (MGH ECOR)
2012 Awarded Research Project Grant (NIH/NIAID)
C. Peer-reviewed Publications
Original Articles:
Reviews and Chapters:
2. Hurley, BP and BA McCormick (2003) Translating tissue culture results into animal models: the case of Salmonella typhimurium. Trends in Microbiol. 11(12);562-9. PMID: 14659688
3. Hurley, BP and BA McCormick (2004) Intestinal Epithelial Defense Systems Protect Against Bacterial Threats. Current Gastroenterology Reports. 6(5):355-61. PMID: 15341710
4. Hurley, BP and BA McCormick (2008) Multiple Roles of Phospholipase A2 during Lung Infection and Inflammation. Infect. Immun. 76(6):2259-2272. PMID: 18411286
Thesis:
Hurley, B.P. Shiga Toxin Translocation Across Polarized Intestinal Epithelial Cells and The Role of Neutrophils in Toxin Movement [Ph.D. Thesis], Boston, MA: Tufts University Sackler School of Biomedical Science, 2001 171 pp.
Abstracts:
(To be presented at national meetings in 2012)
D. Research Support
Ongoing Research Support
NIH/NIAID (R01 AI095338-01A1) Hurley (PI) 2/01/12 – 1/31/17
“The Role of Hepoxilin A3 in Neutrophil Breach of the Infected Airway Mucosa”
The objective of this grant is to explore the role of hepoxilin A3 using both in vitro and in vivo mouse models of acute bacterial pneumonia and to further elucidate the mechanism of hepoxilin A3 synthesis in human lung epithelial cells.
Corporate Sponsored Research Contract Hurley (PI) 05/01/11 – 04/30/12
Pioneer Hi-Bred International, Inc.
“Assessment of an in vitro Human Intestinal Epithelial Cell Model for Evaluation of Protein Cytotoxicity and Bioavailability”
The objective of this grant is to assess an in vitro model of polarized human intestinal epithelial cells for response to apical treatment with a diverse range of protein toxins.
Completed Research Support
MGH Executive Committee On Research Hurley (PI) 12/01/11 – 11/30/12
“The Role of Hepoxilin A3 in Neutrophil Breach of the Infected Airway Mucosa”
This award served as institutional bridge funding to support salary and research activities.
Cystic Fibrosis Foundation Research Grant Hurley (PI) 04/01/08 – 03/31/11
“Role of Eicosanoids and PMN Transmigration in Cystic Fibrosis”
Explored neutrophil trans-epithelial migration in response to infection utilizing CF mutant epithelial cell lines.
NIH NIAID (K22 AI065425) Hurley (PI) 02/01/08 – 05/31/10
“Eicosanoid Production by Infected Lung Epithelial Cells.”
Identified key enzymes responsible for bacterial induced neutrophil trans-epithelial migration present in human lung epithelial cell lines and gained insight into bacterial factors responsible for this phenomenon.
NIH NIAID F32 NRSA AI54054-02 (Individual) Hurley (PI) 07/01/03 – 06/30/05
“Airway Inflammation: Bacterial Epithelial Interactions”
Established and characterized an in vitro model for airway inflammation using alveolar epithelial monolayers grown on permeable Transwells, neutrophils, and pathogenic bacteria.
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