Curriculum Vita

Bobby Cherayil, MD
Associate Immunologist (MGH)
Associate Professor of Pediatrics (HMS)

B. POSITIONS AND HONORS

Academic Appointments
1985-1986 Research fellow, Dept. of Mol. Biophys. & Biochem, Yale University
1986-1988 Research fellow, Whitehead Institute for Biomedical Research
1988-1992 Research fellow, Massachusetts General Hospital Cancer Center
1992-1993 Senior resident in pediatrics, Columbia-Presbyterian Medical Center
1993-1994 Assistant professor of pediatrics, Columbia University
1994-present Associate immunologist, Massachusetts General Hospital
1994-2005 Assistant professor of pediatrics, Harvard Medical School
2005-present Associate professor of pediatrics, Harvard Medical School

Other Professional Positions

Editorial
2002-present Ad hoc reviewer, Cellular Microbiology, Inflammatory Bowel Disease, Journal of Clinical Investigation, Journal of Leukocyte Biology, Microbes and Infection
2005-2009 Associate editor, Journal of Immunology
2009-present Section editor, Journal of Immunology
2009-present Member, editorial board, Infection and Immunity

Grant Review
2003-present Sub-committee on Review of Research Proposals, Massachusetts General Hospital, permanent member
2004 Special Salmonella study section, NIH, ad hoc member
2007-2011 Research Training Awards Committee, CCFA, permanent member
2009 Special study section on “Immune Defense Mechanisms at the Mucosa”, NIH, ad hoc member
2009 NIH Special emphasis panel
2009-present Harvard Catalyst pilot grants review committee, Harvard University, ad hoc member
2011-2012 Ad hoc reviewer, GMPB study section, NIH

Honors and Awards
1972 OBA Gold Medal, St. Joseph's High School, Bangalore, India
1973 National Science Talent Scholarship, New Delhi, India
1974 George Chacko Memorial Award for Best Incoming Student, Christian Medical College, Vellore, India
1977 Capt. Jaisingh Jadhav Prize in Pediatrics, Christian Medical College, Vellore, India
1980 Maria Viakulam David Gold Medal for Best Outgoing Student, Christian Medical College, Vellore, India
1980 The Raja of Panagal Gold Medal for Best Medical Graduate, University of Madras, Madras, India
1990 The Charles A. King Fellowship of the Medical Foundation, Boston, MA
1995 AGA/Sandoz Pharmaceuticals Research Scholar Award
1996 First Award, Crohn's and Colitis Foundation of America
2006 American Society for Microbiology International Visiting Professorship
2007 Senior Research Award, Crohn’s and Colitis Foundation of America
2007 Milton Fund Award, Harvard University

C. SELECTED PUBLICATIONS (last 5 years, out of a total of 45)

1. Srikanth CV, Cherayil BJ. Intestinal innate immunity and the pathogenesis of Salmonella enteritis. Immunol. Res. 2007; 37: 61-77.
2. Harrington L, Srikanth CV, Antony R, Shi HN, Cherayil BJ. A role for natural killer cells in intestinal
inflammation caused by infection with Salmonella enterica serovar Typhimurium. FEMS Immunol. Med.
Microbiol. 2007; 51: 372-380.
3. Weng M, Huntley D, Huang IF, Foye-Jackson O, Wang L, Sarkissian A, Zhou Q, Walker WA, Cherayil BJ, Shi HN. Alternatively activated macrophages in intestinal helminth infection: effects on concurrent bacterial colitis. J. Immunol. 2007; 179: 4721-4731.
4. Harrington L, Srikanth CV, Antony R, Rhee SJ, Mellor AL, Shi HN, Cherayil BJ. Deficiency of indoleamine 2,3-dioxygenase enhances commensal-induced antibody responses and protects against Citrobacter colitis. Infect. Immun. 2008; 76: 3045-3053.
5. Wang L, Johnson EE, Shi HN, Walker WA, Wessling-Resnick M, Cherayil BJ. Attenuated inflammatory
responses in hemochromatosis reveal a role for iron in the regulation of macrophage cytokine translation. J. Immunol. 2008; 181: 2723-2731.
6. Wang L, Cherayil BJ. Ironing out the wrinkles in host defense: interactions between iron homeostasis and innate immunity. J. Innate Immun. 2009; 1: 455-464.
7. Wang L, Harrington L, Trebicka E, Shi HN, Kagan JC, Hong CC, Lin HY, Babitt JL, Cherayil BJ. Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis. J. Clin. Invest. 2009; 119: 3322-3328.
8. Cherayil BJ. Indoleamine 2,3-dioxygenase in intestinal immunity and inflammation. Inflamm. Bowel Dis. 2009; 15: 1391-1396.
9. Johnson EE, Srikanth CV, Sandgren A, Harrington L, Trebicka E, Wang L, Borregaard N, Murray M,
Cherayil BJ. Siderocalin inhbits the intracellular replication of Mycobacterium tuberculosis in macrophages. FEMS Immunol. Med. Microbiol. 2010; 58: 138-145.
10. Charrier GM, Ip WK, Dejardin S, Boyer L, Sokolovska A, Cappillino M, Cherayil BJ, Podolsky D, Kobayashi K, Silverman N, Lacy-Hulbert A, Stuart LM. Identification of Drosophila Yin and PEPT2 as evolutionarily conserved phagosome-associated muramyl dipeptide transporters. J. Biol. Chem. 2010; 285: 20147-20154.
11. Cherayil BJ. Cross-talk between iron homeostasis and intestinal inflammation. Gut Microbes 2010; 1: 65- 69.
12. Johnson EE, Sandgren A, Cherayil BJ, Murray M, Wessling-Resnick M. The role of ferroportin in
macrophage-mediated immunity. Infect. Immun. 2010; 78: 5099-5106.
13. Cherayil BJ. Iron and immunity: immunological consequences of iron deficiency and overload. Arch. Immunol. Ther. Exp. (Warsz.) 2010; 58: 407-415.
14. Wang L, Trebicka E, Fu Y, Waggoner L, Akira S, Fitzgerald KA, Kagan JC, Cherayil BJ. Regulation of lipopolysaccharide-induced translation of tumor necrosis factor a by the Toll-like receptor 4 adaptor protein TRAM. J. Innate Immun. 2011; 3: 437-446.
15. Cherayil BJ. The role of iron in the immune response to bacterial infection. Immunol. Res. 2011; 50: 1-9.
16. Cherayil BJ, Ellenbogen S, Shanmugam NN. Iron and intestinal immunity. Curr. Opin. Gastroenterol. 2011; 27: 523-528.
17. Wang L, Trebicka E, Fu Y, Ellenbogen S, Hong CC, Babitt JL, Lin HY, Cherayil BJ. The bone
morphogenetic protein-hepcidin axis as a therapeutic target in inflammatory bowel disease. Inflamm. Bowel Dis. 2012; 18: 112-119.

D. RESEARCH SUPPORT

Active Support

R01 AI089700 (Principal Investigator) 06/15/11 – 06/14/16
NIH/NIAID
Cross-talk between iron metabolism and intestinal inflammation
The goals of this project are to (1) determine how Hfe deficiency and the associated lowering of hepcidin and intra-macrophage iron attenuate inflammation, (2) determine how intestinal inflammation up-regulates hepcidin, and (3) examine the effect of lowering hepcidin levels on the severity of colitis in mouse models of IBD.

R56 AI089700 (Principal Investigator) 07/01/10 – 06/30/12 (NCE)
NIH/NIAID (ARRA)
Cross-talk between iron metabolism and intestinal inflammation
The goals of this project are to (1) determine how Hfe deficiency and the associated lowering of hepcidin and intra-macrophage iron attenuate inflammation, (2) determine how intestinal inflammation up-regulates hepcidin, and (3) examine the effect of lowering hepcidin levels on the severity of colitis in mouse models of IBD.

Completed Support (last 3 years)

Pilot feasibility project (Principal Investigator) 04/01/07 – 03/31/08
Harvard Clinical Nutrition Research Center
The hyperferritinemia (Hfe) gene in innate immunity
The goal of this project is to examine the impact of the changes in iron metabolism caused by Hfe deficiency on anti-microbial and inflammatory responses.

Milton Fund Award (Principal Investigator) 01/01/08 – 12/31/08
William F. Milton Fund, Harvard University
Siderocalin in immune defense against tuberculosis
The goals of this project are to elucidate the mechanism by which siderocalin inhibits the growth of M. tuberculosis, and to investigate the changes in siderocalin expression during M. tuberculosis infection.

Research Grant (Principal Investigator) 11/01/08 – 10/31/10
Broad Medical Research Program
Iron-based modulation of cytokine biosynthesis for treatment of intestinal inflammation
The goals of this project are to evaluate the ability of reagents that modulate iron homeostasis to reduce the severity of intestinal inflammation in animal models of IBD.

Senior Research Award (Principal Investigator) 07/01/07 – 12/31/10
Crohn’s and Colitis Foundation of America
The role of indoleamine 2,3-dioxygenase (IDO) in intestinal inflammation
The goal of this project is to elucidate the functional role of IDO in the regulation of different types of intestinal inflammation.

Interim Support Fund (Principal Investigator) 04/01/10 – 03/31/11
MGH ECOR
Host iron status and the response to enteric bacterial pathogens
The goal of this project is to study the effects of increased and decreased intra-macrophage iron levels on the immune responses to Salmonella and Citrobacter infection.

Catalyst Grant (Co-investigator) 10/01/09 – 09/30/10
Harvard University
A novel diagnostic test for tuberculosis utilizing antibodies specific for sideroclain-carboxymycobactin complexes
The goal of this project is to develop monoclonal antibodies specific for a complex of the mycobacterial siderophore carboxymycobactin bound to the mammalian protein siderocalin.

P01 DK33506 (Co-investigator) 09/30/05 – 09/29/10
NIH/NIDDK
Barrier function in the GI tract in health and disease
The major goal of this project is to study anti-microbial defense mechanisms in the gastrointestinal tract and how they are perturbed in disease states.