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Recent Publications
(last 5 years)

Bobby Cherayil, MD

Alessio Fasano, MD

Verena Göbel, M

Bryan P. Hurley, PhD >>

Beth McCormick, PhD

Hans-Christian Reinecker, MD

Hai Ning Shi, DVM, PhD

W. Allan Walker, MD

Publications

Bryan P. Hurley, PhD

Original Articles:

  1. Fischer, C.P., Bode, B.P., Hurley, B.P. Souba W.W. Alterations in oxidative metabolism and glutamine transport support glucose production in the tumor-influenced hepatocyte.  J Surg Res.  1997; 69(2):379-84.                    
    http://www.ncbi.nlm.nih.gov/pubmed/9224411
  2. Hurley, B.P., Jacewicz, M., Thorpe, C.M., Lincicome, L.L., King, A.J., Keusch, G.T., Acheson, D.W.K. Shiga toxins 1 and 2 translocate differently across polarized intestinal epithelial cells.  Infect Immun.  1999; 67(12):6670-7.           
    PMC97081 http://www.ncbi.nlm.nih.gov/pubmed/10569789
  3. Thorpe, C.M., Hurley, B.P., Lincicome, L.L., Jacewicz, M.S., Keusch, G.T., Acheson D.W.K..  Shiga toxins stimulate secretion of interleukin-8 from intestinal epithelial cells.  Infect Immun. 1999; 67(11):5985-93.
    PMC96984 http://www.ncbi.nlm.nih.gov/pubmed/10531258
  4. Thorpe, C.M., Flaumenhaft, R., Hurley, B., Jacewicz, M., Acheson, D.W.K., Keusch, G.T. Shiga toxins do not directly stimulate alpha-granule secretion or enhance aggregation of human platelets. Acta Haematol.  1999; 102(1):51-5.
    http://www.ncbi.nlm.nih.gov/pubmed/10473889
  5. Hurley, B.P., Thorpe, C.M., Acheson, D.W.K.  Shiga toxin translocation across intestinal epithelial cells is enhanced by neutrophil transmigration.  Infect. Immun. 2001; 69(10):6148-55. 
    PMC98745 http://www.ncbi.nlm.nih.gov/pubmed/11553554
  6. Thorpe, C.M., Smith, W.E., Hurley, B.P., Acheson D.W.K. Shiga toxins induce, superinduce, and stabilize a variety of C-X-C chemokine mRNA in intestinal epithelial cells resulting in increased chemokine expression.  Infect. Immun.  2001; 69(10):6140-7.
    PMC98744 http://www.ncbi.nlm.nih.gov/pubmed/11553553
  7. Bode, B.P., Fuchs, B.C., Hurley, B.P., Conroy J.L., Suetterlin, J.E., Tanabe, K.K., Rhoads D.B., Abcouwer, S.F., Souba, W.W..   Molecular and functional analysis of glutamine uptake in human hepatoma and liver-derived cells.  Am J Physiol Gastrointest Liver Physiol.  2002; 283(5):G1062-73.
    http://www.ncbi.nlm.nih.gov/pubmed/12381519
  8. Mrsny, R.J., Gewirtz, A.T. , Siccardi,,D., Savidge, T.C.,  Hurley, B.P.,  Madara, JL, McCormick, B.A..  Identification of hepoxilin A3 in inflammatory events: A required role in neutrophil migration across the intestinal epithelia. Proc. Natl. Acad. Sci. USA 2004; 101: 7421-7426. 
    PMC409934 http://www.ncbi.nlm.nih.gov/pubmed/15123795
  9. Spacek L.A., Hurley B.P., Acheson D.W., Granok A., Currie A., Doing K., Sears C.L..  Shiga Toxin-Producing Escherichia coli as a Possible Etiological Agent of Chronic Diarrhea. Clin Infect Dis. 2004; 39(5):E46-8.
    http://www.ncbi.nlm.nih.gov/pubmed/15356801
  10. Hurley, B.P., Siccardi, D., Mrsny, R.J., McComick, B.A..  PMN transepithelial migration induced by Pseudomonas aeruginosa requires the eicosinoid hepoxilin A3. J Immunol. 2004; 173(9):5712-20.
    http://www.ncbi.nlm.nih.gov/pubmed/15494523
  11. Hurley, B.P., Williams, N.L., McCormick, B.A..  Involvement of Phospholipase A2 in Pseudomonas aeruginosa Mediated PMN Trans-epithelial Migration.  Am J Physiol Lung Cell Mol Physiol.  2006; 290(4):L703-9.
    http://www.ncbi.nlm.nih.gov/pubmed/16272174
  12. Köhler, H., Sakaguchi1, T., Hurley, B.P., Kase, B.A., Reinecker, H.C., McCormick, B.A. Salmonella enterica serovar Typhimurium regulates intercellular junction proteins and facilitates transepithelial neutrophil and bacterial passage.  Am J Physiol Gastro. and Liver Physiol.  2007; 293(1):G178-87.
    http://www.ncbi.nlm.nih.gov/pubmed/17615177
  13. Hurley, B.P., Sin, A., McCormick, B.A..  Adhesion Molecules Involved in Hepoxilin A3 Mediated PMN Trans-epithelial Migration.  Clin. and Exp. Immuno.  2008; 151(2):297-305.
    PMC2276941 http://www.ncbi.nlm.nih.gov/pubmed/18005361
  14. Mumy, K.L., Bien, J.D., Pazos, M.A., Gronert, K., Hurley, B.P., McCormick, B.A.  Distinct Isoforms of Phospholipase A2 mediate the ability of Salmonella enterica serotype Typhimurium and Shigella flexneri to induce the transepithelial migration of neutrophils.  Infect. Immun.  2008; 76(8):3614-27.
    PMC2493202 http://www.ncbi.nlm.nih.gov/pubmed/18505810
  15. Hurley, B.P., Goodman, A.L., Murphy, P., Lory, S., McCormick, B.A..  The Two-Component Sensor Response Regulator RoxR / RoxS Plays a Role in Pseudomonas aeruginosa Interactions with Airway Epithelial Cells.  Microbes & Infection.  2010; 12(3):190-8.
    PMC2826603 http://www.ncbi.nlm.nih.gov/pubmed/19961952
  16. Hurley, B.P., Pirzai, W., Mumy, K.L., Gronert, K., McCormick B.A..  Selective Eicosanoid Generating Capacity of Cytoplasmic Phospholipase A2 in Pseudomonas aeruginosa Infected Epithelial Cells.  Am J Physiol Lung Cell Mol Physiol.  2011; 300(2):L286-94.
    PMC3043809 http://www.ncbi.nlm.nih.gov/pubmed/21097525
  17. Tamang D.L., Pirzai W., Priebe G..P, Traficante D.C., Pier G.B., Falck J.R., Morisseau C., Hammock B.D., McCormick B.A., Gronert K., Hurley B.P..  Hepoxilin A3 Facilitates Neutrophilic Breach of Lipoxygenase-Expressing Airway Epithelial Barriers.  J Immunol. 2012; 189(10):4960-9. 
    http://www.ncbi.nlm.nih.gov/pubmed/23045615
  18. Trebicka E., Jacob S., Pirzai W., Hurley B.P., Cherayil B.J..  Role of anti-lipopolysaccharide antibodies in serum bactericidal activity against Salmonella enterica serovar Typhimurium in healthy adults and children in the United States.  Clin Vaccine Immunol. 2013; In press.
    http://www.ncbi.nlm.nih.gov/pubmed/23803904
  19. Kusek, M.E., Pazos, M.A., Pirzai W., Hurley, B.P.In Vitro Co-Culture Assay to Assess Pathogen Induced Neutrophil Trans-Epithelial Migration. J. Vis. Exp. 2013; In press.

Reviews and Chapters:

  1. Thorpe CM, Hurley BP, Acheson DWK.  Shiga Toxin Interactions with the Intestinal Epithelium.  In, Philpott, D.J., ed. Methods in Molecular Medicine. Totowa, NJ: Humana Press, 2002: 273:263-273 
    http://www.ncbi.nlm.nih.gov/pubmed/12375435
  2. Hurley, BP and BA McCormick (2003) Translating tissue culture results into animal models: the case of Salmonella typhimurium. Trends in Microbiol. 11(12);562-9
    http://www.ncbi.nlm.nih.gov/pubmed/14659688
  3. Hurley, BP and BA McCormick (2004) Intestinal Epithelial Defense Systems Protect Against Bacterial Threats. Current Gastroenterology Reports.  6(5):355-61           
    http://www.ncbi.nlm.nih.gov/pubmed/15341710
  4. Hurley, BP and BA McCormick (2008) Multiple Roles of Phospholipase A2 during Lung Infection and Inflammation.  Infect. Immun.  76(6):2259-2272
    PMC2423084 http://www.ncbi.nlm.nih.gov/pubmed/18411286