Recent Publications
(last 5 years)

Bobby Cherayil, MD

Christina S. Faherty, PhD

Alessio Fasano, MD

Verena Göbel, MD

Bryan P. Hurley, PhD

Beth McCormick, PhD

Hans-Christian Reinecker, MD

Hai Ning Shi, DVM, PhD

W. Allan Walker, MD


Bryan P. Hurley, PhD

Original Articles:

  1. Fischer, C.P., Bode, B.P., Hurley, B.P. Souba W.W. Alterations in oxidative metabolism and glutamine transport support glucose production in the tumor-influenced hepatocyte.  J Surg Res.  1997; 69(2):379-84.               
  2. Hurley, B.P., Jacewicz, M., Thorpe, C.M., Lincicome, L.L., King, A.J., Keusch, G.T., Acheson, D.W.K. Shiga toxins 1 and 2 translocate differently across polarized intestinal epithelial cells.  Infect Immun.  1999; 67(12):6670-7.           
  3. Thorpe, C.M., Hurley, B.P., Lincicome, L.L., Jacewicz, M.S., Keusch, G.T., Acheson D.W.K..  Shiga toxins stimulate secretion of interleukin-8 from intestinal epithelial cells.  Infect Immun. 1999; 67(11):5985-93.
  4. Thorpe, C.M., Flaumenhaft, R., Hurley, B., Jacewicz, M., Acheson, D.W.K., Keusch, G.T. Shiga toxins do not directly stimulate alpha-granule secretion or enhance aggregation of human platelets. Acta Haematol.  1999; 102(1):51-5.
  5. Hurley, B.P., Thorpe, C.M., Acheson, D.W.K.  Shiga toxin translocation across intestinal epithelial cells is enhanced by neutrophil transmigration.  Infect. Immun. 2001; 69(10):6148-55. 
  6. Thorpe, C.M., Smith, W.E., Hurley, B.P., Acheson D.W.K. Shiga toxins induce, superinduce, and stabilize a variety of C-X-C chemokine mRNA in intestinal epithelial cells resulting in increased chemokine expression.  Infect. Immun.  2001; 69(10):6140-7.
  7. Bode, B.P., Fuchs, B.C., Hurley, B.P., Conroy J.L., Suetterlin, J.E., Tanabe, K.K., Rhoads D.B., Abcouwer, S.F., Souba, W.W..   Molecular and functional analysis of glutamine uptake in human hepatoma and liver-derived cells.  Am J Physiol Gastrointest Liver Physiol.  2002; 283(5):G1062-73.
  8. Mrsny, R.J., Gewirtz, A.T. , Siccardi,,D., Savidge, T.C.,  Hurley, B.P.,  Madara, JL, McCormick, B.A..  Identification of hepoxilin A3 in inflammatory events: A required role in neutrophil migration across the intestinal epithelia. Proc. Natl. Acad. Sci. USA 2004; 101: 7421-7426. 
  9. Spacek L.A., Hurley B.P., Acheson D.W., Granok A., Currie A., Doing K., Sears C.L..  Shiga Toxin-Producing Escherichia coli as a Possible Etiological Agent of Chronic Diarrhea. Clin Infect Dis. 2004; 39(5):E46-8.
  10. Hurley, B.P., Siccardi, D., Mrsny, R.J., McComick, B.A..  PMN transepithelial migration induced by Pseudomonas aeruginosa requires the eicosinoid hepoxilin A3. J Immunol. 2004; 173(9):5712-20.
  11. Hurley, B.P., Williams, N.L., McCormick, B.A..  Involvement of Phospholipase A2 in Pseudomonas aeruginosa Mediated PMN Trans-epithelial Migration.  Am J Physiol Lung Cell Mol Physiol.  2006; 290(4):L703-9.
  12. Köhler, H., Sakaguchi1, T., Hurley, B.P., Kase, B.A., Reinecker, H.C., McCormick, B.A. Salmonella enterica serovar Typhimurium regulates intercellular junction proteins and facilitates transepithelial neutrophil and bacterial passage.  Am J Physiol Gastro. and Liver Physiol.  2007; 293(1):G178-87.
  13. Hurley, B.P., Sin, A., McCormick, B.A..  Adhesion Molecules Involved in Hepoxilin A3 Mediated PMN Trans-epithelial Migration.  Clin. and Exp. Immuno.  2008; 151(2):297-305.
  14. Mumy, K.L., Bien, J.D., Pazos, M.A., Gronert, K., Hurley, B.P., McCormick, B.A.  Distinct Isoforms of Phospholipase A2 mediate the ability of Salmonella enterica serotype Typhimurium and Shigella flexneri to induce the transepithelial migration of neutrophils.  Infect. Immun.  2008; 76(8):3614-27.
  15. Hurley, B.P., Goodman, A.L., Murphy, P., Lory, S., McCormick, B.A..  The Two-Component Sensor Response Regulator RoxR / RoxS Plays a Role in Pseudomonas aeruginosa Interactions with Airway Epithelial Cells.  Microbes & Infection.  2010; 12(3):190-8.
  16. Hurley, B.P., Pirzai, W., Mumy, K.L., Gronert, K., McCormick B.A..  Selective Eicosanoid Generating Capacity of Cytoplasmic Phospholipase A2 in Pseudomonas aeruginosa Infected Epithelial Cells.  Am J Physiol Lung Cell Mol Physiol.  2011; 300(2):L286-94.
  17. Tamang D.L., Pirzai W., Priebe G..P, Traficante D.C., Pier G.B., Falck J.R., Morisseau C., Hammock B.D., McCormick B.A., Gronert K., Hurley B.P..  Hepoxilin A3 Facilitates Neutrophilic Breach of Lipoxygenase-Expressing Airway Epithelial Barriers.  J Immunol. 2012; 189(10):4960-9.
  18. Trebicka E., Jacob S., Pirzai W., Hurley B.P., Cherayil B.J..  Role of anti-lipopolysaccharide antibodies in serum bactericidal activity against Salmonella enterica serovar Typhimurium in healthy adults and children in the United States.  Clin Vaccine Immunol. 2013; In press.
  19. Kusek, M.E., Pazos, M.A., Pirzai W., Hurley, B.P.In Vitro Co-Culture Assay to Assess Pathogen Induced Neutrophil Trans-Epithelial Migration. J. Vis. Exp. 2013; In press.

Reviews and Chapters:

  1. Thorpe CM, Hurley BP, Acheson DWK.  Shiga Toxin Interactions with the Intestinal Epithelium.  In, Philpott, D.J., ed. Methods in Molecular Medicine. Totowa, NJ: Humana Press, 2002: 273:263-273
  2. Hurley, BP and BA McCormick (2003) Translating tissue culture results into animal models: the case of Salmonella typhimurium. Trends in Microbiol. 11(12);562-9
  3. Hurley, BP and BA McCormick (2004) Intestinal Epithelial Defense Systems Protect Against Bacterial Threats. Current Gastroenterology Reports.  6(5):355-61      
  4. Hurley, BP and BA McCormick (2008) Multiple Roles of Phospholipase A2 during Lung Infection and Inflammation.  Infect. Immun.  76(6):2259-2272