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Recent Publications
(last 5 years)

Bobby Cherayil, MD

Alessio Fasano, MD >>

Verena Göbel, MD

Bryan P. Hurley, PhD

Beth McCormick, PhD

Hans-Christian Reinecker, MD

Hai Ning Shi, DVM, PhD

W. Allan Walker, MD

Publications

Alessio Fasano, MD

  1. Hernandez L, Johnson TC, Naiyer AJ, Kryszak D, Ciaccio EJ, Min A, Bodenheimer HC Jr, Brown RS Jr, Fasano A, Green PH. Chronic hepatitis C virus and celiac disease, is there an association? Dig Dis Sci. 2008; 53:256-261.
  2. Song KH, Fasano A, Eddington ND. Effect of the six-mer synthetic peptide (AT1002) fragment of zonula occludens toxin on the intestinal absorption of cyclosporin A. Int J Pharm. 2008; 351(1-2):8-14.
  3. Song KH, Fasano A, Eddington ND. Enhanced nasal absorption of hydrophilic markers after dosing with AT1002, a tight junction modulator. Eur J Pharm Biopharm. 2008; 69(1):231-237.
  4. Lammers KM, Lu R, Brownley J, Lu B, Gerard C, Thomas K, Rallabhandi P, Shea-Donohue T, Tamiz A, Alkan S, Netzel-Arnett S, Antalis T, Vogel SN, Fasano A. Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3. Gastroenterology. 2008; 135:194-204.
  5. Abu-Zekry M, Kryszak D, Diab M, Catassi C, Fasano A. Prevalence of celiac disease in Egyptian children disputes the east-west agriculture-dependent spread of the disease. J Pediatr Gastroenterol Nutr. 2008; 47:136-40.
  6. Rallabhandi P, Nhu QM, Toshchakov VY, Piao W, Medvedev AE, Hollenberg MD, Fasano A, Vogel SN. Analysis of PAR2 and TLR4 signal transduction:  A novel paradigm for receptor cooperativity. J Biol Chem. 2008; 283(36):24314-25.
  7. Harris KM, Fasano A, Mann DL. Cutting edge: IL-1 controls the IL-23 response induced by gliadin, the etiologic agent in celiac disease. J Immunol. 2008; 181:4457-60.
  8. Catassi C, Fasano A. Is this really celiac disease? Pitfalls in diagnosis. Curr Gastroenterol Rep. 2008 10:466-72.
  9. Lu R, Fasano S, Madayiputhiya N, Morin NP, Nataro J, Fasano A. Isolation, identification, and characterization of small bioactive peptides from Lactobacillus GG conditional media that exert both anti-gram-negative and gram-positive bactericidal activity. J Pediatr Gastroenterol Nutr. 2009; 49:23-30.
  10. Simpson M, Mojibian M, Barriga K, Scott FW, Fasano A, Rewers M, Norris JM. An exploration of Glo-3A antibody levels in children at increased risk for type 1 diabetes mellitus. Pediatr Diabetes. 2009; 10:563-72.
  11. Sapone A, Lammers KM, Mazzarella G, Mikhailenko I, Cartenì M, Casolaro V, Fasano A. differential mucosal IL-17 expression in two gliadin-induced disorders: gluten sensitivity and the autoimmune enteropathy celiac disease. Int Arch Allergy Immunol. 2009; 152:75-80.
  12. Tripathi A, Lammers KM, Goldblum S, Shea-Donohue T, Netzel-Arnett S, Buzza MS, Antalis TM, Vogel SN, Zhao A, Yang S, Arrietta MC, Meddings JB, Fasano A. Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2. Proc Natl Acad Sci U S A. 2009; 106:16799-804. PMID: 19805376.
  13. Nhu QM, Shirey K, Teijaro JR, Farber DL, Netzel-Arnett S, Antalis TM, Fasano A, Vogel SN. Novel signaling interactions between proteinase-activated receptor 2 and Toll-like receptors in vitro and in vivo. Mucosal Immunol. 2010; 3:29-39.
  14. Harris KM, Fasano A, Mann DL. Monocytes differentiated with IL-15 support Th17 and Th1 responses to wheat gliadin: implications for celiac disease. Clin Immunol. 2010; 135:430-9. PMID: 20153259.
  15. Buzza MS, Netzel-Arnett S, Shea-Donohue T, Zhao A, Lin CY, List K, Szabo R, Fasano A, Bugge TH, Antalis TM. Membrane-anchored serine protease matriptase regulates epithelial barrier formation and permeability in the intestine. Proc Natl Acad Sci U S A. 2010; 107:4200-5. PMID: 20142489.
  16. Visser JT, Lammers K, Hoogendijk A, Boer MW, Brugman S, Beijer-Liefers S, Zandvoort A, Harmsen H, Welling G, Stellaard F, Bos NA, Fasano A, Rozing J. Restoration of impaired intestinal barrier function by the hydrolysed casein diet contributes to the prevention of type 1 diabetes in the diabetes-prone BioBreeding rat. Diabetologia. 2010; 53(12):2621-2628.
  17. Catassi C, Kryszak D, Bhatti B, Sturgeon C, Helzlsouer K, Clipp SL, Gelfond D, Puppa E, Sferruzza A, Fasano A. Natural history of celiac disease autoimmunity in a USA cohort followed since 1974. Ann Med. 2010; 42:530-8. PMID: 20868314.
  18. Cascella NG, Kryszak D, Bhatti B, Gregory P, Kelly DL, Mc Evoy JP, Fasano A, Eaton WW. Prevalence of celiac disease and gluten sensitivity in the United States clinical antipsychotic trials of intervention effectiveness study population. Schizophr Bull. 2011; 37:94-100.
  19. Goldblum SE, Rai U, Tripathi A, Thakar M, De Leo L, Di Toro N, Not T, Ramachandran R, Puche AC, Hollenberg MD, Fasano A. The active Zot domain (aa 288-293) increases ZO-1 and myosin 1C serine/threonine phosphorylation, alters interaction between ZO-1 and its binding partners, and induces tight junction disassembly through proteinase activated receptor 2 activation. FASEB J. 2011; 25:144-158.
  20. Lammers KM, Khandelwal S, Chaudhry F, Kryszak D, Puppa EL, Casolaro V, Fasano A. Identification of a novel immunomodulatory gliadin peptide that causes interleukin-8 release in a chemokine receptor CXCR3-dependent manner only in patients with coeliac disease. Immunology. 2011; 132:432-40. PMID: 21091908.
  21. Sapone A, Lammers KM, Casolaro V, Cammarota M, Giuliano MT, De Rosa M, Stefanile R, Mazzarella G, Tolone C, Russo MI, Esposito P, Ferraraccio F, Cartenì M, Riegler G, de Magistris L, Fasano A. Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity. BMC Med. 2011; 9:23. PMID: 21392369.
  22. Salerno-Goncalves R, Fasano A, Sztein MB. Engineering of a multicellular organotypic model of the human intestinal mucosa. Gastroenterology. 2011; 141:e18-20. PMID: 21723866.
  23. Nair P, Kamra A, Kessie G, Kalavapudi S, Chen J-H, Shores R, Madairos L, Fasano A, Nair P. Markers of inflammation and lineage on exfoliated colonic cells in exfoliated colonic cells in pediatric inflammatory bowel disease. J Gastrointest Dig Syst, 2011; 8:1-6. PMID: 23519721
  24. Siniscalco D, Sapone A, Giordano C, Cirillo A, de Novellis V, de Magistris L, Rossi F, Fasano A, Maione S, Antonucci N. The expression of caspases is enhanced in peripheral blood mononuclear cells of autism spectrum disorder patients. J Autism Dev Disord.; 2012; 42:1403-1410. PMID:  21969075.
  25. Netzel-Arnett S, Buzza MS, Shea-Donohue T, Desilets A, Leduc R, Fasano A, Bugge TH, Antalis TM. Matriptase protects against experimental colitis and promotes intestinal barrier recovery. Inflamm Bowel Dis.; 2012; 18:1303-1316 PMID:  22081509.
  26. Silva MA, Jury J, Sanz Y, Wiepjes M, Huang X, Murray JA, David CS, Fasano A, Verdu EF. Increased bacterial translocation in gluten-sensitive mice is independent of small intestinal paracellular permeability defect. Dig Dis Sci. 2012; 38-47. PMID: 21822909.
  27. Sellitto M, Bai G, Serena G, Fricke WF, Sturgeon C, Gajer P, White JR, Koenig SS, Sakamoto J, Boothe D, Gicquelais R, Kryszak D, Puppa E, Catassi C, Ravel J, Fasano A. Proof of concept of microbiome-metabolome analysis and delayed gluten exposure on celiac disease autoimmunity in genetically at-risk infants. PLoS ONE. 2012; 7:e33387.
  28. Rossi F, Bellini G, Tolone C, Luongo L, Mancusi S, Papparella A, Sturgeon C, Fasano A, Nobili B, Perrone L, Maione S, del Giudice EM. The cannabinoid receptor type 2 Q63R variant increases the risk of celiac disease: implication for a novel molecular biomarker and future therapeutic intervention. Pharmacol Res. 2012; 66:88-94. PMID: 22465144.
  29. Ahn R, Ding YC, Murray J, Fasano A, Green PH, Neuhausen SL, Garner C. Association analysis of the extended MHC region in celiac disease implicates multiple independent susceptibility loci. PLoS ONE. 2012; 7:e36926. PMID: 22615847.
  30. Lionetti E, Castellaneta S, Pulvirenti A, Tonutti E, Francavilla R, Fasano A, Catassi C; Italian Working Group of Weaning and Celiac Disease Risk. Prevalence and natural history of potential celiac disease in at-family-risk infants prospectively investigated from birth. J Pediatr. 2012; 161:908-914.PMID: 22704250.
  31. Jackson J, Eaton W, Cascella N, Fasano A, Warfel D, Feldman S, Richardson C, Vyas G, Linthicum J, Santora D, Warren KR, Carpenter WT Jr, Kelly DL. A gluten-free diet in people with schizophrenia and anti-tissue transglutaminase or anti-gliadin antibodies. Schizophr Res. 2012; 140:262-3. PMID: 22771303.
  32. Faherty C, Harper JM, Shea-Donohue T, Barry EM, Kaper JB, Fasano A, Nataro JP. Gastrointestinal conditions in children with autism spectrum disorder: developing a research agenda. PLoS ONE. 2012; 7:e49980. PMID: 23166804.
  33. Faherty C, Harper JM, Shea-Donohue T, Barry EM, Kaper, JB, Fasano, A, Nataro, J. Chromosomal and plasmid-encoded factors of shigella flexneri induce secretogenic activity ex vivo. PLoS ONE. 2012; 7:e49980.
  34. Gibert A, Kruizinga AG, Neuhold S, Houben GF, Canela MA, Fasano A, Catassi C. Might gluten traces in wheat substitutes pose a risk in patients with celiac disease? A population-based probabilistic approach to risk estimation. Am J Clin Nutr. 2013; 97:109-116. PMID: 23193005.
  35. Vajro P, Paolella G, Fasano A. Microbiota and gut-liver axis: a mini-review on their influences on obesity and obesity related liver disease. J Pediatr Gastroenterol Nutr. 2013; 56:461-8 PMID: 23287807.
  36. Fiorentino M, Ding H, Blanchard TG, Czinn SJ, Sztein MB, Fasano A. Helicobacter pylori-induced disruption of monolayer permeability and pro-inflammatory cytokine secretion in polarized human gastric epithelial cells. Infect Immun. 2013; 81: 876-83 PMID: 23297384.
  37. Hollon JR, Cureton PA, Martin ML, Puppa E, Fasano A. Trace gluten contamination may play a role in mucosal and clinical recovery in a subgroup of diet-adherent non-responsive celiac disease patients. BMC Gastroenterol. 2013; 13(40). doi:10.1186/1471-230X-13-40. 
  38. Fiorentino M, Lammers KM, Levine MM, Sztein MB, Fasano A. In vitro intestinal mucosal epithelial responses to wild-type Salmonella typhi and attenuated typhoid vaccines. Frontiers in Immunology. 2013; 4:1-15.
  39. Cascella NG, Santora D, Gregory P, Kelly DL, Fasano A, Eaton WW. Increased prevalence of transglutaminase 6 antibodies in sera from schizophrenia patients. Schizophr Bull. 2012; Apr 19. [Epub ahead of print]. PMID: 22516148.
  40. Rittirsch D, Flierl MA, Nadeau BA, Day DE, Huber-Lang MS, Grailer JJ, Zetoune FS, Andjelkovic AV, Fasano A, Ward PA.  Zonulin as prehaptoglobin2 regulates lung permeability and activates the complement system. Am J Physiol Lung Cell Mol Physiol. 2013 Apr 5. [Epub ahead of print]
  41. Siniscalco D, Sapone A, Giordano C, Cirillo A, de Magistris L, Rossi F, Fasano A, Bradstreet JJ, Maione S, Antonucci N. Cannabinoid Receptor Type 2, but not Type 1, is Up-Regulated in Peripheral Blood Mononuclear Cells of Children Affected by Autistic Disorders. J Autism Dev Disord. 2013 Apr 13. [Epub ahead of print]
  42. Alaish SM, Smith AD, Timmons J, Greenspon J, Eyvazzadeh D, Murphy E, Shea-Donahue T, Cirimotich S, Mongodin E, Zhao A, Fasano A, Nataro JP, Cross A. Gut microbiota, tight junction protein expression, intestinal resistance, bacterial translocation and mortality following cholestasis depend on the genetic background of the host. Gut Microbes. 2013 Apr 15; 4(4). [Epub ahead of print].
  43. Fasano A, Araya M, Bhatnagar S, Cameron D, Catassi C, Dirks M, Mearin ML, Ortigosa L, Phillips A. Celiac Disease Working Group. Federation of International Societies of Pediatric Gastroenterology, Hepatology, and Nutrition Consensus report on celiac disease. J Pediatr Gastroenterol Nutr. 2008; 47:214-9.
  44. Fasano A. Physiological, pathological, and therapeutic implications of zonulin-mediated intestinal barrier modulation: living life on the edge of the wall. Am J Pathol. 2008; 173:1243-52.
  45. Catassi C, Fasano A. Celiac disease. Curr Opin Gastroenterol. 2008; 24:687-91.
  46. Visser J, Rozing J, Sapone A, Lammers K, Fasano A. Tight junctions, intestinal permeability, and autoimmunity: celiac disease and type 1 diabetes paradigms. Ann N Y Acad Sci. 2009; 1165:195-205.
  47. Fasano A. Surprises from celiac disease. Sci Am. 2009; 301:54-61.
  48. Zawahir S, Safta A, Fasano A. Pediatric celiac disease. Curr Opin Pediatr. 2009; 1165:655-660.
  49. Fasano A. Should we screen for celiac disease? BMJ 2009; 339:b3592.
  50. Fasano A, Counts D. Commentary on anti-pituitary antibodies in children with newly diagnosed celiac disease: a novel finding contributing to linear growth. Am J Gastroenterol. 2010; 105(3):697-8.PMID: 20203647.
  51.  Catassi C, Fasano A. Celiac disease diagnosis: simple rules are better than complicated algorithms. Am J Med. 2010; 123:691-3.PMID: 20670718.
  52. Shea-Donohue T, Fasano A, Smith A, Zhao A. Enteric pathogens and gut function: role of cytokines and STATs. Gut Microbes. 2010; 1:316-324. PMID: 21327040.
  53.  Fasano A. Zonulin and its regulation of intestinal barrier function:  the biological door to inflammation, autoimmunity, and cancer. Physiol Rev. 2011; 91:151-175.
  54. Fasano A, Catassi C. Early feeding practices and their impact on development of celiac disease. Nestle Nutr Workshop Ser Pediatr Program. 2011; 68:201-209. PMID:  22044901.
  55. Jackson JR, Eaton WW, Cascella NG, Fasano A, Kelly DL. Neurologic and psychiatric manifestations of celiac disease and gluten sensitivity. Psychiatr Q. 2012; 91-102. PMID: 21877216.
  56. Fasano A. Leaky gut and autoimmune disease. Clin Rev Allergy Immunol. 2012; 71-78. PMID: 22109896.
  57. Sapone A, Bai J, Ciacci C, Dolinsek J, Green PH, Hadjivassiliou M, Kaukinen K, Rostami K, Sander DS, Schumann M, Ullrich R, Villalta D, Volta U, Catassi C, Fasano A. Spectrum of gluten-related disorders: consensus on new nomenclature and classification. BMC Med. 2012; 10: 13. PMID: 22313950.
  58. Ludvigsson JF, Leffler DA, Bai JC, Biagi F, Fasano A, Green PH, Hadjivassiliou M, Kaukinen K, Kelly CP, Leonard JN, Lundlin KE, Murray JA, Sanders DS, Walker MM, Zingone F, Ciacci C. The Olso definitions for coeliac disease and related terms. Gut. 2013; 62:43-52PMID: 22345659.
  59. Ludvigsson JF, Fasano A. Timing of introduction of gluten and celiac disease risk. Ann Nutr Metab. 2012; 60 Suppl 2:22-9. doi: 10.1159/000335335. Epub 2012 Apr 30. Review. PMID: 22555186.
  60. Fasano A. Zonulin, regulation of tight junctions, and autoimmune diseases. Ann N Y Acad Sci. 2012; 1258:25-33. PMID: 22731712.
  61. Fasano A. Intestinal permeability and its regulation by zonulin: diagnostic and therapeutic implications. Clin Gastroenterol Hepatol. 2012; 10:1096-100. PMID: 22902773.
  62. Vanuytsel T, Senger S, Fasano A, Shea-Donohue T. Major signaling pathways in intestinal stem cells. Biochim Biophys Acta. 2013; 1830: 2410-2426; PMID: 22922290.
  63. Reilly NR, Fasano A, Green PH. Presentation of celiac disease. Gastrointest Endosc Clin N Am. 2012; 22:613-21. PMID: 23083982.
  64. Fasano A. Novel therapeutic/integrative approaches for celiac disease and dermatitis herpetiformis. Clin Dev Immunol. 2012; 2012:959061. doi: 10.1155/2012/959061. Epub 2012 Oct 10. PMID: 23093980.
  65. Coury DL, Ashwood P, Fasano A, Fuchs G, Geraghty M, Kaul A, Mawe G, Patterson P, Jones NE. Gastrointestinal conditions in children with autism spectrum disorder: developing a research agenda. Pediatrics. 2012; 130 Suppl 2:S160-8. PMID: 23118247.
  66. Fabbri P, Calabrò AS, Hashimoto T, Fasano A, Caproni M. Novel advances in dermatitis herpetiformis. Clin Dev Immunol. 2012; 2012:450109. Epub 2012 Dec 19. PMID: 23316253.
  67. Fasano A, Catassi C. Clinical practice. Celiac disease. N Engl J Med. 2012; 367:2419-26. PMID: 23252527.
  68. Fasano A. Intestinal permeability and its regulation by zonulin: diagnostic and therapeutic implications. Clin Gastroenterol and Hepatol: Advances in Translational Science. 2012; 10:1096-1100.
  69. Bai JC, Fried M, Corazza GR, Schuppan D, Farthing M, Catassi C, Greco L, Cohen H, Ciacci C, Eliakim R, Fasano A, González A, Krabshuis JH, Lemair A; Review team: World gastroenterology organisation global guidelines on celiac disease. J Clin Gastroenterol. 2013; 47:121-6. PMID: 23314668.
  70. Barry EM, Pasetti MF, Sztein MB, Fasano A, Kotloff K, Levine MM. Progress and pitfalls in shigella vaccine research. Nat Rev Gastroenterol Hepatol. 2013; 10: 245-255.