Hai Ning Shi, DVM, PhD
Associate Professor of Pediatrics, Havard Medical School
Mucosal Immunology Laboratory
Massachusetts General Hospital and Harvard Medical School
114 16th Street 114-3503
Charlestown, MA. 02129
- 1982 DVM, Veterinary Medicine, Qinghai University School of Animal Science and Veterinary Medicine, Qinghai, P. R. China
- 1996 PhD, Parasitology/Immunology, McGill University, Montreal, Canada
- 1996 PostDoc, Mucosal Immunology, Massachusetts General Hospital and Harvard Medical School
A. Positions and Honors.
Positions and Employment
- 1990-1991 Visiting Scientist, Institute of Parasitology, McGill University, Canada
- 1991-1996 Research Assistant and PhD student, Institute of Parasitology, McGill University, Canada.
- 1996-1999 Postdoctoral Fellow, Mucosal Immunology Lab, Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital & Harvard Medical School
- 1999-2001 Instructor in Pediatrics, Harvard Medical School
- 2002-2010 Assistant Immunologist, Assistant Professor of Pediatrics, Massachusetts General Hospital,
Harvard Medical School
- 2011 Associate Immunologist, Massachusetts General Hospital
- 2012 Associate Professor of Pediatrics, Harvard Medical School
Other Experience and Professional Memberships
- 1998 American Association of Immunologists
- 2001 American Gastroenterology Association
- 2005 American Society for Microbiology
- 2005 Society for Mucosal Immunology
- 2010 Editorial Board Member, Infection and Immunity
- 2010 Ad hoc Reviewer NIH NIAID Special Emphasis Panel ZAI1 PA- I(M2).
- 2010 NIH The Pathogenic Eukaryotes Study Section (PTHE) Temporary Member
Awards and Honors
- 1990-1992 Differential Fee Waiver Awards for International Students, McGill University, Canada.
- 1992 Summer Bursary, McGill University.
- 1992 Graduate Student Travel Award, Canadian Society of Zoology.
- 1993 Lynden Laird Lyster Memorial Award in Parasitology, McGill University.
- 1994 Wyeth Graduate Student Award, The Canadian Society of Nutritional Sciences and The Canadian Federation of Biological Societies.
- 1998-2001 Research Fellowship Award, Crohn’s & Colitis Foundation of America (CCFA)
- 2001-2002, Career Development Award, CCFA.
- 2003 First Award, CCFA. Relinquished when KO1 was awarded.
- 2003-2007 KO1 Award, NIH.
Current Research Support
- R01 NIH/NIDDK DK082427 05/01/10-04/30/15
Immunomodulatory effects of helminthes on mucosal immunity
The studies proposed in this R01 project will determine the immuomodulatory role of intestinal helminth parasites in bacteria-associated and T cell-mediated intestinal inflammation.
- P30 NIH/NIDDK DK40561 (Walker) 07/01/12-6/30/17
Nutrition Obesity Research Center at Harvard
Specific aims of project: The major specific aims are: 1) to provide research in basic areas of biology relevant to problems in clinical nutrition; 2) to promote the study of clinical nutrition and application of knowledge derived there from within the HMS, MIT and HSHP community; 3) to promote interactions among scientists and clinical investigators to show relevance to advancing the science of clinical nutrition; and 4) to attract "basic" investigators into the domain of clinical nutrition to promote an environment and mechanism to develop new investigator-initiated research.
Role: Director Cell Biology Core (Shi)
- R01 AI081807 (Mizoguchi) 12/01/10-11/30/15
Inducible Regulatory B cells BREG
The major goal of this project is to identify the differentiation pathway of inducible regulatory B cells with immune regulatory ability independent of immunoglobulins.
- Nestec Ltd (Shi) 01/01/11-12/31/13
Nestec Research Grant
In this proposed investigation, utilizing a recently established novel murine model, we seek to understand how early immune development is influenced by maternal factors.
Completed Research Support
- R21 DK074727 Hai Ning Shi (P.I.) 10/1/07-8/31/10
Immunomodulation of bacteria-associated colitis by helminth infection
The goal of this project is to characterize the helminth-induced phenotypic and functional alterations in the subset of dendritic cells (DCs) and to elucidate the role of helminth-primed DCs and subset of DCs in the alterations of the host defense against enteric bacteria and the exacerbation of bacteria-associated intestinal inflammation.
- KO1 DK59996 Hai Ning Shi (P.I.) 7/1/2003-6/30/06
Triggering intestinal inflammation
The specific aims focus on epithelial cell-commensal bacterial interaction in intestinal inflammation and the role and mechanisms of bacterial products and components in the induction and regulation of intestinal inflammatory response.