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People of the MIBRC

Principal Investigators:

Bobby Cherayil, MD

Alessio Fasano, MD

Verena Göbel, MD

Bryan Hurley, PhD

Hai Ning Shi, DVM, PhD

W. Allan Walker, MD

Collaborators:

Beth McCormick, PhD

Hans-Christian Reinecker, MD

Curriculum Vitae

Bobby Cherayil, MD

Immunologist, Massachusetts General Hospital
Associate Professor of Pediatrics, Harvard Medical School

Office Address:

Department of Pediatrics
Mucosal Immunology Laboratory
Massachusetts General Hospital and Harvard Medical School
114 16th Street 114-3503
Charlestown, MA. 02129

Phone: (617) 726-4170
FAX: (617) 726-4172
Email: cherayil@helix.mgh.harvard.edu

Education

POSITIONS AND HONORS

Academic Appointments

Other Professional Positions

Editorial

Grant Review

Honors and Awards

SELECTED PUBLICATIONS (last 5 years, out of a total of 45)

  1. Srikanth CV, Cherayil BJ. Intestinal innate immunity and the pathogenesis of Salmonella enteritis. Immunol. Res. 2007; 37: 61-77.
  2. Harrington L, Srikanth CV, Antony R, Shi HN, Cherayil BJ. A role for natural killer cells in intestinal
    inflammation caused by infection with Salmonella enterica serovar Typhimurium. FEMS Immunol. Med.
    Microbiol. 2007; 51: 372-380.
  3. Weng M, Huntley D, Huang IF, Foye-Jackson O, Wang L, Sarkissian A, Zhou Q, Walker WA, Cherayil BJ, Shi HN. Alternatively activated macrophages in intestinal helminth infection: effects on concurrent bacterial colitis. J. Immunol. 2007; 179: 4721-4731.
  4. Harrington L, Srikanth CV, Antony R, Rhee SJ, Mellor AL, Shi HN, Cherayil BJ. Deficiency of indoleamine 2,3-dioxygenase enhances commensal-induced antibody responses and protects against Citrobacter colitis. Infect. Immun. 2008; 76: 3045-3053.
  5. Wang L, Johnson EE, Shi HN, Walker WA, Wessling-Resnick M, Cherayil BJ. Attenuated inflammatory
    responses in hemochromatosis reveal a role for iron in the regulation of macrophage cytokine translation. J. Immunol. 2008; 181: 2723-2731.
  6. Wang L, Cherayil BJ. Ironing out the wrinkles in host defense: interactions between iron homeostasis and innate immunity. J. Innate Immun. 2009; 1: 455-464.
  7. Wang L, Harrington L, Trebicka E, Shi HN, Kagan JC, Hong CC, Lin HY, Babitt JL, Cherayil BJ. Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis. J. Clin. Invest. 2009; 119: 3322-3328.
  8. Cherayil BJ. Indoleamine 2,3-dioxygenase in intestinal immunity and inflammation. Inflamm. Bowel Dis. 2009; 15: 1391-1396.
  9. Johnson EE, Srikanth CV, Sandgren A, Harrington L, Trebicka E, Wang L, Borregaard N, Murray M,
    Cherayil BJ. Siderocalin inhbits the intracellular replication of Mycobacterium tuberculosis in macrophages. FEMS Immunol. Med. Microbiol. 2010; 58: 138-145.
  10. Charrier GM, Ip WK, Dejardin S, Boyer L, Sokolovska A, Cappillino M, Cherayil BJ, Podolsky D, Kobayashi K, Silverman N, Lacy-Hulbert A, Stuart LM. Identification of Drosophila Yin and PEPT2 as evolutionarily conserved phagosome-associated muramyl dipeptide transporters. J. Biol. Chem. 2010; 285: 20147-20154.
  11. Cherayil BJ. Cross-talk between iron homeostasis and intestinal inflammation. Gut Microbes 2010; 1: 65- 69.
  12. Johnson EE, Sandgren A, Cherayil BJ, Murray M, Wessling-Resnick M. The role of ferroportin in
    macrophage-mediated immunity. Infect. Immun. 2010; 78: 5099-5106.
  13. Cherayil BJ. Iron and immunity: immunological consequences of iron deficiency and overload. Arch. Immunol. Ther. Exp. (Warsz.) 2010; 58: 407-415.
  14. Wang L, Trebicka E, Fu Y, Waggoner L, Akira S, Fitzgerald KA, Kagan JC, Cherayil BJ. Regulation of lipopolysaccharide-induced translation of tumor necrosis factor a by the Toll-like receptor 4 adaptor protein TRAM. J. Innate Immun. 2011; 3: 437-446.
  15. Cherayil BJ. The role of iron in the immune response to bacterial infection. Immunol. Res. 2011; 50: 1-9.
  16. Cherayil BJ, Ellenbogen S, Shanmugam NN. Iron and intestinal immunity. Curr. Opin. Gastroenterol. 2011; 27: 523-528.
  17. Wang L, Trebicka E, Fu Y, Ellenbogen S, Hong CC, Babitt JL, Lin HY, Cherayil BJ. The bone
    morphogenetic protein-hepcidin axis as a therapeutic target in inflammatory bowel disease. Inflamm. Bowel Dis. 2012; 18: 112-119.

D. RESEARCH SUPPORT

Active Support

R01 AI089700 (Principal Investigator) 06/15/11 – 06/14/16
NIH/NIAID
Cross-talk between iron metabolism and intestinal inflammation
The goals of this project are to (1) determine how Hfe deficiency and the associated lowering of hepcidin and intra-macrophage iron attenuate inflammation, (2) determine how intestinal inflammation up-regulates hepcidin, and (3) examine the effect of lowering hepcidin levels on the severity of colitis in mouse models of IBD.

R56 AI089700 (Principal Investigator) 07/01/10 – 06/30/12 (NCE)
NIH/NIAID (ARRA)
Cross-talk between iron metabolism and intestinal inflammation
The goals of this project are to (1) determine how Hfe deficiency and the associated lowering of hepcidin and intra-macrophage iron attenuate inflammation, (2) determine how intestinal inflammation up-regulates hepcidin, and (3) examine the effect of lowering hepcidin levels on the severity of colitis in mouse models of IBD.

Completed Support (last 3 years)

Pilot feasibility project (Principal Investigator) 04/01/07 – 03/31/08
Harvard Clinical Nutrition Research Center
The hyperferritinemia (Hfe) gene in innate immunity
The goal of this project is to examine the impact of the changes in iron metabolism caused by Hfe deficiency on anti-microbial and inflammatory responses.

Milton Fund Award (Principal Investigator) 01/01/08 – 12/31/08
William F. Milton Fund, Harvard University
Siderocalin in immune defense against tuberculosis
The goals of this project are to elucidate the mechanism by which siderocalin inhibits the growth of M. tuberculosis, and to investigate the changes in siderocalin expression during M. tuberculosis infection.

Research Grant (Principal Investigator) 11/01/08 – 10/31/10
Broad Medical Research Program
Iron-based modulation of cytokine biosynthesis for treatment of intestinal inflammation
The goals of this project are to evaluate the ability of reagents that modulate iron homeostasis to reduce the severity of intestinal inflammation in animal models of IBD.

Senior Research Award (Principal Investigator) 07/01/07 – 12/31/10
Crohn’s and Colitis Foundation of America
The role of indoleamine 2,3-dioxygenase (IDO) in intestinal inflammation
The goal of this project is to elucidate the functional role of IDO in the regulation of different types of intestinal inflammation.

Interim Support Fund (Principal Investigator) 04/01/10 – 03/31/11
MGH ECOR
Host iron status and the response to enteric bacterial pathogens
The goal of this project is to study the effects of increased and decreased intra-macrophage iron levels on the immune responses to Salmonella and Citrobacter infection.

Catalyst Grant (Co-investigator) 10/01/09 – 09/30/10
Harvard University
A novel diagnostic test for tuberculosis utilizing antibodies specific for sideroclain-carboxymycobactin complexes
The goal of this project is to develop monoclonal antibodies specific for a complex of the mycobacterial siderophore carboxymycobactin bound to the mammalian protein siderocalin.

P01 DK33506 (Co-investigator) 09/30/05 – 09/29/10
NIH/NIDDK
Barrier function in the GI tract in health and disease
The major goal of this project is to study anti-microbial defense mechanisms in the gastrointestinal tract and how they are perturbed in disease states.