Selected Publications

1. Ip, WKE, K Takahashi, KJ Moore, LM Stuart and RAB Ezekowitz. Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome. J Experimental Medicine. 2008; 205:169-181



2. Webb NR, KJ Moore. Macrophage-derived foam cells in atherosclerosis: Lessons from murine models and implications for therapy. Current Drug Targets. 2007; Dec;8(12):1249-63



3. Stuart LM, SA Bell, CR Stewart, JM Silver, J Richard, AA Tseng, A Zhang, JB El Khoury, KJ Moore. CD36 signals to the actin cytoskeleton and regulates microglial migration via a p130Cas complex. J Biological Chemistry. 2007; 282:27392-401



4. Stewart, CR, A Haw III, R Lopez, TO McDonald, JM Callaghan, MJ McConville, KJ Moore, GJ Howlett and KD O’Brien. Serum amyloid P component co-localizes with apolipoproteins in human atheroma: functional implications. J Lipid Research. 2007; 48:2162-71



5. Seimon TA, A Obstfeld, KJ Moore, DT Golenbock, I Tabas. Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages. Proceedings National Academy of Science USA. 2006; 103:19794-99



6. Brundert M, Heeren J, Bahar-Bayansar M, Ewert A, Moore KJ, Rinninger F. Selective uptake of HDL Cholesteryl esters and cholesterol efflux from mouse peritoneal macrophages independent of SR-BI. J Lipid Research. 2006; 47:2408-21



7. Howlett GJ, Moore KJ. Untangling the role of amyloid in atherosclerosis. Current Opinion Lipidology. 2006; 17:541-7



8. Lacy-Hulbert A, Moore KJ. Designer macrophages: Oxidative metabolism fuels inflammation repair. Cell Metabolism. 2006; 4:7-8



9. Moore KJ, Freeman MW. Scavenger receptors in atherosclerosis: Beyond lipid uptake. Arteriosclerosis, Thrombosis and Vascular Biology. 2006; 26:1702-11



10. Heller EA, Liu E, Tager A, Koehn SL, Freeman MW, Moore KJ, Luster AD, Gerszten RE. The chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells. Circulation. 2006; 113: 2301-12



11. Stuart LM, Deng J, Silver JM, Takahashi K, Tseng AA, Hennessy EJ, Ezekowitz RA, Moore KJ. Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain. J Cell Biology. 2005; 170:477-85



12. Moore KJ, Kunjathoor VV, Koehn SL, Manning JJ, Tseng AA, Silver JM, McKee M, Freeman MW. Loss of scavenger receptor-mediated lipid uptake by scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice. J Clinical Investigation. 2005; 115: 2192-201



13. Ly NP, Komatsuzaki K, Fraser IP, Tseng AA, Prodhan P, Moore KJ, Kinane TB. Netrin-1 inhibits leukocyte migration in vitro and in vivo. Proceedings National Academy of Science USA. 2005; 102:14729-34



14. Stewart CR, Tseng AA, Mok YF, Staples MK, Schiesser CH, Lawrence LJ, Varghese JN, Moore KJ, Howlett GJ. Oxidation of low-density lipoproteins induces amyloid-like structures that are recognized by macrophages. Biochemistry. 2005; 44:9108-16



15. Heller EA, Liu E, Tager AM, Sinha S, Roberts JD, Koehn SL, Libby P, Aikawa ER, Chen JQ, Huang P, Freeman MW, Moore KJ, Luster AD, Gerszten RE. Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment. Circulation. 2005; 112:578-86



16. Kunjathoor VV, Tseng AA, Medeiros LA, Khan T, Moore KJ. Beta-amyloid promotes accumulation of lipid peroxides by inhibiting CD36-mediated clearance of oxidized lipoproteins. J Neuroinflammation. 2004; 1:23



17. Ricci R, Sumara G, Sumara I, Rozenberg I, Kurrer M, Akhmedov A, Hersberger M, Eriksson U, Eberli FR, Becher B, Boren J, Chen M, Cybulsky MI, Moore KJ, Freeman MW, Wagner EF, Matter CM, Luscher TF. Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis. Science. 2004; 306:1558-61



18. Björkbacka H, Kunjathoor VV, Moore KJ, Koehn S, Ordija CM, Lee MA, Means T, Halmen K, Luster AD, Golenbock DT, Freeman MW. Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways. Nature Medicine. 2004; 10(4):416-21



19. Medeiros LA, Khan T, El Khoury JB, Pham CL, Hatters DM, Howlett GJ, Lopez R, O’Brien KD, Moore KJ. Fibrillar amyloid protein present in atheroma activates CD36 signal transduction. J Biological Chemistry. 2004; 279:10643-8



20. El Khoury JB, Moore KJ, Means TK, Leung J, Terada K, Toft M, Freeman MW, Luster AD. CD36 mediates the innate host response to b-amyloid. J Experimental Medicine. 2003; 197(12):1657-66



21. Freeman MW, Moore KJ. eLiXiRs for restraining inflammation. Nature Medicine. 2003. 9(2):169



22. Moore KJ, El Khoury J, Medeiros LA, Terada K, Geula C, Luster AD, Freeman MW. A CD36-initiated signaling cascade mediates inflammatory effects of b-amyloid. J Biological Chemistry. 2002; 277(49):47373-9



23. Moore KJ, Fitzgerald ML, Freeman MW. Peroxisome proliferator-activated receptors in macrophage biology: friend or foe? Current Opinion Lipidology. 2001; 12:519-27



24. Moore KJ, Rosen ED, Fitzgerald ML, Randow F, Andersson LP, Altshuler D, Milstone DS, Mortensen RM, Spiegelman BM, Freeman MW. The role of PPAR-gamma in macrophage differentiation and cholesterol uptake. Nature Medicine. 2001; 7:41-7



25. Moore KJ, Andersson LP, Ingalls RR, Monks BG, Li R, Arnaout MA, Golenbock DT, Freeman MW. Divergent response to LPS and bacteria in CD14-deficient murine macrophages. J Immunology. 2000; 165:4272-80



26. Moore KJ, Freeman MW. Embryonal stem (ES) cell derived macrophages: a cellular system that facilitates the genetic dissection of macrophage function. In: Baker AH, editor. Methods in Molecular Medicine, Vascular Disease: Molecular Biology & Gene Therapy Protocols.1999; p. 343-55



27. Moore KJ, Fabunmi RP, Andersson LP, Freeman MW. In vitro-differentiated embryonic stem cell macrophages: a model system for studying atherosclerosis-associated macrophage functions. Arteriosclerosis, Thrombosis and Vascular Biology. 1998; 18(10):1647-54