Dr. Otto specializes in the cognitive-behavioral treatment of anxiety and mood disorders, and has developed clinical-research programs at Massachusetts General Hospital (MGH) for the treatment of panic disorder, posttraumatic stress disorder, social phobia, bipolar disorder, psychotic disorders, substance dependence, and medication discontinuation in patients with panic disorder. Dr. Otto's research activities are closely tied to his clinical interests and target investigations of the etiology and treatment of anxiety, mood, and substance-use disorders. Of particular interest to Dr. Otto is the development and testing of new treatments, including the combination of pharmacologic and cognitive-behavioral strategies for treatment-refractory and substance abusing patients, and the modification of treatment packages for novel populations (e.g., Cambodian refugees). He has published over 170 articles, chapters, and books spanning these research interests. Dr. Otto serves as a section editor for Cognitive and Behavioral Practice, and on the editorial boards of Behavior Research and Therapy, Clinical Psychology: Science and Practice, Depression and Anxiety, Journal of Anxiety Disorders, Journal Watch in Psychiatry, and Psychotherapy and Psychosomatics. He also serves on the scientific advisory board for the Anxiety Disorders Association of America and the governing board for the Association for Advancement of Behavior Therapy. Dr. Otto directs fellowship and internship training in cognitive-behavior therapy at MGH, and has been a regular provider of continuing education and continuing medical education workshops across the United States and abroad.