1 research assistant

I am a pediatric infectious disease clinician, with a primary interest in bacterial enteric infections.  My primary research focus involved an NIH-funded collaboration between scientists in the Division of Infectious Diseases at Massachusetts General Hospital and the International Centre for Diarrhoeal Disease Research in Dhaka, Bangladesh, to analyze human immune responses following Vibrio cholerae infection and to identify factors associated with susceptibility to cholera. The goal of this work is to better understand protective immunity to cholera, with hopes that this knowledge may lead to improved vaccination strategies. My other interest is in the area of typhoid fever, where I am working on strategies to identify novel inhibitors of intracellular growth of Salmonella enterica. This project is currently supported by the NIH Molecular Libraries Probe Production Centers Network (MLPCN).

Selected recent references:

Harris JB, Khan AI, Larocque RC, Dorer DJ, Chowdhury F, Faruque AS, Sack DA, Ryan ET, Qadri F, Calderwood SB. Blood Group, Immunity, and Risk of Infection with Vibrio cholerae in an Area of Endemicity. Infect Immun. 2005; 73 (11): 7422-7.

Schwartz BS, Harris JB, Khan AI, Larocque RC, Sack DA, Malek MA, Faruque AS, Qadri F, Calderwood SB, Luby SP, Ryan ET. Diarrheal epidemics in Dhaka, Bangladesh, during three consecutive floods: 1988, 1998, and 2004. Am J Trop Med Hyg. 2006; 74 (6): 1067-73.

Harris JB, Baresch-Bernal A, Rollins SM, Alam A, Larocque RC, Bikowski M, Peppercorn AF, Handfield M, Hillman JD, Qadri F, Calderwood SB, Hohmann E, Breiman RF, Brooks WA, Ryan ET. Identification of In Vivo-Induced Bacterial Protein Antigens during Human Infection with Salmonella enterica Serovar Typhi. Infect Immun. 2006;74(9):5161-8.

Harris JB, LaRocque RC, Chowdhury F, Khan AI, Logvinenko T, Faruque ASG, Ryan ET, Qadri F, Calderwood SB. Susceptibility to Vibrio cholerae Infection in a Cohort of Household Contacts of Patients with Cholera in Bangladesh. PLoS Negl Trop Dis 2008; 2(4): 221.

Jayasekera CR, Harris JB, Bhuiyan MS, Chowdhury F, Khan AI, Faruque ASG, LaRocque RC, Ryan ET, Ahmed R, Qadri F, Calderwood SB. Cholera toxin-specific memory B cell responses are induced in patients with dehydrating diarrhea caused by Vibrio cholerae O1. J Infect Dis. 2008; 198(7): 1055-1061.